Rapid and efficient synthesis of a new series of 2-aryl-5-fluoro-6(4-phenylpiperazin-1-yl)-1H-benzimidazoles using microwave heating
MetadataShow full item record
CitationMenteşe, E., Yılmaz, F., İslamoğlu, F., & Kahveci, B. (2015). Rapid and Efficient Synthesis of a New Series of 2-Aryl-5-Fluoro-6-(4-Phenylpiperazin-1-Yl)-1H-Benzimidazoles Using Microwave Heating. Journal of Chemical Research, 206–208. https://doi.org/10.3184/174751915X14268750943001
A new series of 2-aryl-5-fluoro-6-(4-phenylpiperazin-1-yl)-1H-benzimidazoles was synthesised from the reaction of 4-fluoro-5-(4-phenylpiperazin-1-yl) benzene-1,2-diamine and iminoester hydrochlorides. 4-Fluoro-5-(4-phenylpiperazin-1-yl) benzene-1,2-diamine was prepared from the reduction of 5-fluoro-2-nitro-4-(4-phenylpiperazin-1-yl) aniline by using Pd/C (10%) catalyst and hydrazine hydrate under microwave irradiation. the structures of newly synthesised compounds were identified by H-1 NMR, C-13 NMR, mass spectroscopy and elemental analysis data.