dc.contributor.author | Cüre, Erkan | |
dc.contributor.author | Cüre, Medine Cumhur | |
dc.contributor.author | Tümkaya, Levent | |
dc.contributor.author | Kalkan, Yıldıray | |
dc.contributor.author | Aydın, İbrahim | |
dc.contributor.author | Kırbaş, Aynur | |
dc.contributor.author | Yılmaz, Arif | |
dc.contributor.author | Yüce, Süleyman | |
dc.contributor.author | Gökçe, Mehmet Fatih | |
dc.date.accessioned | 2020-12-19T20:03:01Z | |
dc.date.available | 2020-12-19T20:03:01Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Cure, E., Cure, M.C., Tumkaya, L., Kalkan, Y., Aydin, I., Kirbas, A., Yilmaz, A. ve diğerleri, (2014).Topiramate ameliorates abdominal aorta cross-clamping induced liver injury in rats.Saudi Journal of Gastroenterology, 20(5), 297-303.https://doi.org/10.4103/1319-3767.141690 | |
dc.identifier.issn | 1319-3767 | |
dc.identifier.issn | 1998-4049 | |
dc.identifier.uri | https://doi.org/10.4103/1319-3767.141690 | |
dc.identifier.uri | https://hdl.handle.net/11436/3064 | |
dc.description | Cure, Medine Cumhur/0000-0001-9253-6459; cure, erkan/0000-0001-7807-135X; | en_US |
dc.description | WOS: 000344521800007 | en_US |
dc.description | PubMed: 25253365 | en_US |
dc.description.abstract | Background and Aim: Ischemia/reperfusion (I/R) injury in the liver occurs after a prolonged period of ischemia followed by restoration of hepatic blood perfusion. During the surgery of abdominal aorta, I/R injury causes damage to lower extremities and many organs, especially liver. the antioxidant and tumor necrosis factor-alpha (TNF-alpha) suppression effects of topiramate (TPM) have been reported in several studies. We evaluated the potential protective effect of TPM on cellular damage in liver tissue during I/R injury. Materials and Methods: Thirty male Wistar albino rats were divided into three groups: Control, I/R, and I/R plus TPM (I/R + TPM) groups. Laparotomy without I/R injury was performed in the control group. After laparotomy, cross-ligation of infrarenal abdominal aorta was applied for 2 h in I/R groups that was followed by 2 h of reperfusion. TPM (100 mg/kg/day) was orally administrated to the animals in the I/R + TPM group for seven consecutive days before I/R procedure. Results: the I/R group's TNF-alpha and interleukin-6 (IL-6) levels were significantly higher than those of the control (P = 0.010; P = 0.002) and I/R + TPM groups (P = 0.010; P = 0.002, respectively). Asymmetric dimethyl arginine (ADMA) levels of I/R group were higher than the control (P = 0.015) and I/R + TPM groups. I/R caused serious histopathological damage to liver tissue; however, TPM led to very low histopathological changes. Conclusion: Our data demonstrated that TPM treatment prominently decreases the severity of liver I/R injury. TPM pretreatment may have preventive effects on liver injury via I/R during intra-abdominal surgery. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wolters Kluwer Medknow Publications | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Asymmetric dimethyl arginine | en_US |
dc.subject | Carbonic anhydrase II | en_US |
dc.subject | Ischemia reperfusion | en_US |
dc.subject | Liver | en_US |
dc.subject | Topiramate | en_US |
dc.title | Topiramate ameliorates abdominal aorta cross-clamping induced liver injury in rats | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Cüre, Erkan | |
dc.contributor.institutionauthor | Cüre, Medine Cumhur | |
dc.contributor.institutionauthor | Tümkaya, Levent | |
dc.contributor.institutionauthor | Kalkan, Yıldıray | |
dc.contributor.institutionauthor | Aydın, İbrahim | |
dc.contributor.institutionauthor | Kırbaş, Aynur | |
dc.contributor.institutionauthor | Yılmaz, Arif | |
dc.contributor.institutionauthor | Yüce, Süleyman | |
dc.contributor.institutionauthor | Gökçe, Mehmet Fatih | |
dc.identifier.doi | 10.4103/1319-3767.141690 | |
dc.identifier.volume | 20 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 297 | en_US |
dc.identifier.endpage | 303 | en_US |
dc.ri.edit | oa | en_US |
dc.relation.journal | Saudi Journal of Gastroenterology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |