dc.contributor.author | Şahin, Serap Baydur | |
dc.contributor.author | Ayaz, Teslime | |
dc.contributor.author | Cüre, Medine Cumhur | |
dc.contributor.author | Sezgin, Hacer | |
dc.contributor.author | Ural, Ülkü Mete | |
dc.contributor.author | Balık, Gülşah | |
dc.contributor.author | Şahin, Figen Kır | |
dc.date.accessioned | 2020-12-19T20:03:03Z | |
dc.date.available | 2020-12-19T20:03:03Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Sahin, S.B., Ayaz, T., Cure, M.C., Sezgin, H., Ural, U.M., Balik, S., Sahin, F.K. (2014). Fibroblast growth factor 21 and its relation to metabolic parameters in women with polycystic ovary syndrome. Scandinavian Journal of Clinical & Laboratory Investigation, 74(6), 465-469. https://doi.org/10.3109/00365513.2014.900821 | en_US |
dc.identifier.issn | 0036-5513 | |
dc.identifier.issn | 1502-7686 | |
dc.identifier.uri | https://doi.org/10.3109/00365513.2014.900821 | |
dc.identifier.uri | https://hdl.handle.net/11436/3073 | |
dc.description | Cure, Medine Cumhur/0000-0001-9253-6459 | en_US |
dc.description | WOS: 000342056100001 | en_US |
dc.description | PubMed: 24724557 | en_US |
dc.description.abstract | Objective. the aim of this study was to compare the serum levels of fibroblast growth factor 21 (FGF-21) between patients with polycystic ovary syndrome (PCOS) and control subjects and to assess the possible relation with the hormonal and metabolic parameters. Methods. A total of 91 patients with PCOS and 53 age- and body mass index (BMI)-matched healthy controls were included in the study. We evaluated anthropometric, hormonal and metabolic parameters in all the cases. Serum FGF-21 and high sensitive C-reactive protein (hsCRP) levels were measured by ELISA. Results. Mean fasting glucose and insulin, homeostasis model assessment insulin resistance index (HOMA-IR), triglyceride, total cholesterol, low density lipoprotein cholesterol, total testosterone, dehydroepiandrosterone sulfate (DHEAS) levels were significantly higher in PCOS patients. Serum FGF-21 levels were similar in PCOS (236.8 +/- 171.2 pg/ml) and the control (224.6 +/- 128.9 pg/ml) group (p = 0.654). FGF-21 level had no correlation with BMI, waist circumference, HOMA-IR, hsCRP and lipid parameters. However there was a significant negative correlation between FGF-21 and DHEAS levels (r = -0.309, p = 0.003). Conclusion. FGF-21 levels were similar in women with PCOS compared with those of age- and BMI-matched controls. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis Ltd | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Polycystic ovary syndrome | en_US |
dc.subject | Fibroblast Growth Factor 21 | en_US |
dc.subject | HOMA-IR | en_US |
dc.subject | dehydroepiandrosterone sulfate | en_US |
dc.subject | high sensitive C-reactive protein | en_US |
dc.title | Fibroblast growth factor 21 and its relation to metabolic parameters in women with polycystic ovary syndrome | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Şahin, Serap Baydur | |
dc.contributor.institutionauthor | Ayaz, Teslime | |
dc.contributor.institutionauthor | Cüre, Medine Cumhur | |
dc.contributor.institutionauthor | Sezgin, Hacer | |
dc.contributor.institutionauthor | Ural, Ülkü Mete | |
dc.contributor.institutionauthor | Balık, Gülşah | |
dc.contributor.institutionauthor | Şahin, Figen Kır | |
dc.identifier.doi | 10.3109/00365513.2014.900821 | |
dc.identifier.volume | 74 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 465 | en_US |
dc.identifier.endpage | 469 | en_US |
dc.relation.journal | Scandinavian Journal of Clinical & Laboratory Investigation | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |