dc.contributor.author | Başoğlu, Serap | |
dc.contributor.author | Ülker, Serdar | |
dc.contributor.author | Alpay-Karaoğlu, Şengül | |
dc.contributor.author | Demirbaş, Neslihan | |
dc.date.accessioned | 2020-12-19T20:03:12Z | |
dc.date.available | 2020-12-19T20:03:12Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Basoglu, S., Ulker, S., Alpay-Karaoglu, S., Demirbas, N., (2014).Microwave-assisted synthesis of some hybrid molecules containing penicillanic acid or cephalosporanic acid moieties and investigation of their biological activities.Medicinal Chemistry Research, 23(6), 3128-3143.https://doi.org/10.1007/s00044-013-0898-4 | |
dc.identifier.issn | 1054-2523 | |
dc.identifier.issn | 1554-8120 | |
dc.identifier.uri | https://doi.org/10.1007/s00044-013-0898-4 | |
dc.identifier.uri | https://hdl.handle.net/11436/3119 | |
dc.description | Alpay Karaoglu, Sengul/0000-0003-1047-8350 | en_US |
dc.description | WOS: 000334184400039 | en_US |
dc.description.abstract | Ethyl 4-amino-2-fluorophenylpiperazin-1-carboxylates containing a 1,3-oxazol(idin)e, 5-thioxo-1,2,4-triazole, 1,3,4-thiadiazole, 5-thioxo-1,3,4-oxadiazole, or 1,3-thiazole nucleus were obtained starting from ethyl piperazine-1-carboxylate (1) by several steps. the treatment of amine, 3 or hydrazide, 9 with several aromatic aldehydes generated the corresponding arylmethyleneamino (3a-f) or arylidenehydrazino (12a-c) compounds. the Mannich reaction between the 1,2,4-triazole or 1,3,4-oxadiazole compounds and 7-aca produced cephalosporanic acid derivatives. Penicillanic acid derivatives were obtained when 6-apa was used in the Mannich reactions. the synthesized compounds were screened for their antimicrobial, antilipase, and antiurease activities. Some of them were found to possess good-moderate antimicrobial activity against the test microorganisms. Two compounds exhibited antiurease activity, and four of them displayed antilipase activity. | en_US |
dc.description.sponsorship | Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [107T333]; Karadeniz Technical University, BAP, TurkeyKaradeniz Technical University [8623] | en_US |
dc.description.sponsorship | This Project was supported by Scientific and Technological Research Council of Turkey (TUBITAK, Project No: 107T333) and Karadeniz Technical University, BAP, Turkey (Ref. No. 8623) and is gratefully acknowledged. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer Birkhauser | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Piperazine | en_US |
dc.subject | 1,3-Oxa(thia) zole | en_US |
dc.subject | 5-Oxo-1,3-oxazolidine | en_US |
dc.subject | 1,2,4-Triazole | en_US |
dc.subject | 7-Aminocephalosporanic acid | en_US |
dc.subject | 6-Aminopenicillanic acid | en_US |
dc.subject | Biological activity | en_US |
dc.title | Microwave-assisted synthesis of some hybrid molecules containing penicillanic acid or cephalosporanic acid moieties and investigation of their biological activities | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.contributor.institutionauthor | Ülker, Serdar | |
dc.contributor.institutionauthor | Alpay-Karaoğlu, Şengül | |
dc.identifier.doi | 10.1007/s00044-013-0898-4 | |
dc.identifier.volume | 23 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 3128 | en_US |
dc.identifier.endpage | 3143 | en_US |
dc.ri.edit | oa | en_US |
dc.relation.journal | Medicinal Chemistry Research | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |