dc.contributor.author | Cüre, Erkan | |
dc.contributor.author | Cüre, Medine Cumhur | |
dc.contributor.author | Tümkaya, Levent | |
dc.contributor.author | Kalkan, Yıldıray | |
dc.contributor.author | Aydın, İbrahim | |
dc.contributor.author | Kırbaş, Aynur | |
dc.contributor.author | Yılmaz, Arif | |
dc.contributor.author | Yüce, Süleyman | |
dc.contributor.author | Yücel, Ahmet Fikret | |
dc.date.accessioned | 2020-12-19T20:03:45Z | |
dc.date.available | 2020-12-19T20:03:45Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Cure, E., Cure, M.C., Tumkaya, L., Kalkan, Y., Aydin, I., Kirbas, A., Yilmaz, A., ve diğerleri (2014). Adalimumab Ameliorates Abdominal Aorta Cross Clamping Which Induced Liver Injury in Rats. Biomed Research International, 2014, article number 907915. https://doi.org/10.1155/2014/907915 | |
dc.identifier.issn | 2314-6133 | |
dc.identifier.issn | 2314-6141 | |
dc.identifier.uri | https://doi.org/10.1155/2014/907915 | |
dc.identifier.uri | https://hdl.handle.net/11436/3224 | |
dc.description | Cure, Medine Cumhur/0000-0001-9253-6459; cure, erkan/0000-0001-7807-135X | en_US |
dc.description | WOS: 000330529500001 | en_US |
dc.description | PubMed: 24551855 | en_US |
dc.description.abstract | The aim of this study was to investigate the possible protective effects of adalimumab (ADA) on cell damage in rat liver tissue during ischemia/reperfusion (I/R) injury of infrarenal abdominal aorta. Thirty male Wistar-albino rats were divided into three groups: control, I/R, and I/R+ADA, each group containing 10 animals. Laparotomy without I/R injury was performed in the control group animals. Laparotomy in the I/R group was followed by two hours of infrarenal abdominal aortic cross ligation and then two hours of reperfusion. ADA (50 mg/kg) was administered intraperitoneally as a single dose, to the I/R+ADA group, five days before I/R. the tumor necrosis factor-alpha (TNF-alpha) (pg/mg protein) and nitric oxide (NO) (mu mol/g protein) levels in the I/R group (430.8 +/- 70.1, 8.0 +/- 1.1, resp.) were significantly higher than those in the I/R+ADA group (338.0 +/- 71.6, P = 0.006; 6.3 +/- 1.2, P = 0.008) and the control group (345.5 +/- 53.3, P = 0.008; 6.5 +/- 1.5, P = 0.010, resp.). I/R causes severe histopathological injury to the liver tissue, but ADA leads to much less histopathological changes. ADA treatment significantly decreased the severity of liver I/R injury. ADA pretreatment may have protective effects on experimental liver injury. | en_US |
dc.description.sponsorship | RTEU Bilimsel Arastirmalar Proje birimi (BAP)Recep Tayyip Erdogan University [2012.106.03.6] | en_US |
dc.description.sponsorship | Source of support is RTEU Bilimsel Arastirmalar Proje birimi (BAP), Project no. 2012.106.03.6. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Hindawi Ltd | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Ischemia-reperfusion injury | en_US |
dc.subject | Nitric-oxide synthase | en_US |
dc.subject | Reduces infarct size | en_US |
dc.subject | Urea cycle enzymes | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Ischemia/reperfusion injury | en_US |
dc.subject | Arginase inhibition | en_US |
dc.subject | Renal injury | en_US |
dc.subject | Infliximab | en_US |
dc.subject | Protects | en_US |
dc.title | Adalimumab ameliorates abdominal aorta cross clamping which induced liver injury in rats | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Cüre, Erkan | |
dc.contributor.institutionauthor | Cüre, Medine Cumhur | |
dc.contributor.institutionauthor | Tümkaya, Levent | |
dc.contributor.institutionauthor | Kalkan, Yıldıray | |
dc.contributor.institutionauthor | Aydın, İbrahim | |
dc.contributor.institutionauthor | Kırbaş, Aynur | |
dc.contributor.institutionauthor | Yılmaz, Arif | |
dc.contributor.institutionauthor | Yüce, Süleyman | |
dc.contributor.institutionauthor | Yücel, Ahmet Fikret | |
dc.identifier.doi | 10.1155/2014/907915 | |
dc.identifier.volume | 2014 | en_US |
dc.ri.edit | oa | en_US |
dc.relation.journal | Biomed Research International | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |