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dc.contributor.authorMengeloğlu, Fırat Zafer
dc.contributor.authorTaş, Tekin
dc.contributor.authorKoçoğlu, Esra
dc.contributor.authorÇopur Çiçek, Aysegül
dc.contributor.authorYanık, Keramettin
dc.contributor.authorGüneş, Hayati
dc.contributor.authorÇiftçi, İhsan Hakkı
dc.contributor.authorDurmaz, Süleyman
dc.contributor.authorBucak, Özlem
dc.contributor.authorGüçkan, Rıdvan
dc.contributor.authorTerzi, Hüseyin Agah
dc.contributor.authorYavuz, Muhsine Zeynep
dc.date.accessioned2020-12-19T20:04:01Z
dc.date.available2020-12-19T20:04:01Z
dc.date.issued2013
dc.identifier.citationMengeloglu, F.Z., Tas, T., Kocoglu, E., Copur Cicek, A., Yanik, K., Gunes, H. ve diğerleri (2013). In vitro activity of ceftaroline to MRSA isolates: a multicenter study. Mikrobiyoloji Bulteni, 47(4), 677-683.en_US
dc.identifier.issn0374-9096
dc.identifier.urihttps://hdl.handle.net/11436/3268
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TVRZeE5UQTFOUT09en_US
dc.descriptionWOS: 000328010300011en_US
dc.descriptionPubMed: 24237436en_US
dc.description.abstractMethicillin-resistant Staphylococcus aureus (MRSA) is an emerging pathogen that cause severe community- and hospital-acquired infections. Studies continue on searching alternatives due to the limited number of therapeutic options in MRSA infections. Ceftaroline is a wide-spectrum new generation cephalosporin which has been begun to be used in treatment of skin and respiratory tract infections caused by MRSA. the aim of this study was to investigate the in vitro activity of ceftaroline against MRSA strains isolated from various clinical specimens in microbiology laboratories of seven hospitals located at different provinces (Bolu, Samsun, Rize, Tekirdag, Sakarya, Amasya, Osmaniye) of Turkey. A total of 192 MRSA isolates (89 skin/wound/abscess, 38 blood, 36 respiratory tract, 29 urine/sterile body fluids/catheter) were included in the study, and ceftaroline susceptibilities of the strains were detected by broth microdilution method. MIC values of 181 (94.3%) isolates were determined as <= 1 mu g/ml meaning of susceptible according to the criteria of CLSI, and MIC values of 11(5.7%) isolates were found as 2 mu g/mL indicating intermediate susceptibility. the range of MIC values of the isolates was found between 0.25-2 mu g/ml. the rates of intermediate isolates have varied between 0-12.5% from the participating centers. MIC50 and MIC90 values of all the isolates were determined as 0.5 mu g/ml and 1 mu g/ml, respectively. No significant differences were found between the centers in terms of mean MIC values (p > 0.05). MIC50 and MIC90 values in Samsun and Bolu isolates were found to be the same with the whole group, however, MIC50 and MIC90 were 0.5 mu g/ml and 0.5 mu g/ml in Amasya isolates and 1 mu g/ml and 1 mu g/ml in Rize, Tekirdag, Osmaniye and Sakarya isolates, respectively. When evaluating MIC50 and MIC90 values and isolation rates of intermediate strains according to the specimen types, there were no significant differences (p > 0.05). Susceptibility rates to ceftaroline and the distribution profiles of MIC values of the isolates obtained from seven centers of Turkey have been detected similar with the previous American and European reports. With this study, initial data on the activity of ceftaroline against MRSA were obtained from Turkey. These preliminary findings indicate that ceftaroline is effective even on Turkish isolates and can be a suitable treatment in cases requiring wide-spectrum antimicrobiotic use, however further large-scaled studies are needed.en_US
dc.language.isoturen_US
dc.publisherAnkara Microbiology Socen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMRSAen_US
dc.subjectCeftarolineen_US
dc.subjectSusceptibilityen_US
dc.subjectMICen_US
dc.subjectBroth microdilutionen_US
dc.subjectTurkeyen_US
dc.titleIn vitro activity of ceftaroline to MRSA isolates: a multicenter studyen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorÇopur Çiçek, Aysegül
dc.identifier.volume47en_US
dc.identifier.issue4en_US
dc.identifier.startpage677en_US
dc.identifier.endpage683en_US
dc.relation.journalMikrobiyoloji Bultenien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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