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Elevated serum YKL-40 level predicts myocardial reperfusion and in-hospital MACE in patients with STEMI

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Erişim

info:eu-repo/semantics/closedAccess

Tarih

2013

Yazar

Çetin, Mustafa
Kocaman, Sinan Altan
Çanga, Aytun
Kırbaş, Aynur
Yılmaz, Adnan
Erdoğan, Turan
Akgül, Ö.
Uğurlu, Y.
Durakoğlugil, Murtaza Emre

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Künye

Cetin, M., Kocaman, S. A., Canga, A., Kırbaş, A., Yılmaz, A., Erdoğan, T., Akgül, O., Uğurlu, Y., & Durakoğlugil, M. E. (2013). Elevated serum YKL-40 level predicts myocardial reperfusion and in-hospital MACE in patients with STEMI. Herz, 38(2), 202–209. https://doi.org/10.1007/s00059-012-3671-4

Özet

Background: Macrophages in atherosclerotic plaques secrete YKL-40, a new biomarker of acute and chronic inflammation in patients with stable CAD. We hypothesized that YKL-40 may be a specific marker reflecting the burden of localized inflammation in myocardium and a predictor in patients with STEMI. In this study, we investigated the relationship of YKL-40 to in-hospital major adverse cardiac events (MACE), reperfusion parameters and its predictors in patients with STEMI. Methods: In total, 80 patients with STEMI and no history of prior coronary artery disease (CAD), who underwent primary percutaneous coronary intervention (p-PCI), were enrolled consecutively. In addition, 30 patients with normal coronary arteries (NCA) were enrolled as a control group. Cardiac biomarker levels including creatinine kinase-MB fraction (CK-MB), troponin-I, admission glucose and inflammatory markers including leukocytes and YKL-40 levels were measured as admission values. Results: In our study, YKL-40 levels correlated to high-sensitivity CRP levels (r = 0.333, p = 0.003), TIMI risk score (r = 0.445, p < 0.001), age (r = 0.477, p < 0.001), pain to balloon time (r = 0.432, p < 0.001), leukocyte and neutrophil count (r = 0.386, p < 0.001 and r = 0.430, p < 0.001, respectively), hemoglobin (r = - 0.345, p = 0.002), admission and fasting blood glucose (r = 0.388, p < 0.001 and r = 0.427, p < 0.001), creatinine levels (r = 0.395, p < 0.001) and myocardial blush grade (r = - 0.334, p = 0.004). When the patients were divided into two groups determined by presence or absence of MACE, the patients with MACE had significantly higher levels of YKL-40 in comparison to the patients without MACE and the control group (194 ± 104, 114 ± 61 and 110 ± 53 ?g/L, p < 0.001, respectively). In multivariate logistic regression analysis in STEMI patients, only YKL-40 level (OR: 1.011, 95%CI: 1.002-1.019, p = 0.011) and leukocyte count (OR: 1.264, 95%CI: 1.037-1.540, p = 0.020) were the independent predictors for MACE. Sensitivity and specificity of YKL-40 to predict MACE, when 125 ?g/l was accepted as a cut-off value, were 84% and 70%, respectively. Conclusion: We found that serum YKL-40 is related to older age, increased admission glucose levels, leukocyte counts and decreased hemoglobin levels; YKL-40 level and leukocyte count independently predicted MACE. © 2012 Urban & Vogel, Muenchen.

Kaynak

Herz

Cilt

38

Sayı

2

Bağlantı

https://doi.org/10.1007/s00059-012-3671-4
https://hdl.handle.net/11436/4128

Koleksiyonlar

  • PubMed İndeksli Yayınlar Koleksiyonu [2440]
  • Scopus İndeksli Yayınlar Koleksiyonu [5917]
  • TF, Dahili Tıp Bilimleri Bölümü Koleksiyonu [1555]
  • TF, Temel Tıp Bilimleri Bölümü Koleksiyonu [690]



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