dc.contributor.author | Çetin, Mustafa | |
dc.contributor.author | Kocaman, Sinan Altan | |
dc.contributor.author | Çanga, Aytun | |
dc.contributor.author | Kırbaş, Aynur | |
dc.contributor.author | Yılmaz, Adnan | |
dc.contributor.author | Erdoğan, Turan | |
dc.contributor.author | Akgül, Ö. | |
dc.contributor.author | Uğurlu, Y. | |
dc.contributor.author | Durakoğlugil, Murtaza Emre | |
dc.date.accessioned | 2020-12-19T20:16:06Z | |
dc.date.available | 2020-12-19T20:16:06Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Cetin, M., Kocaman, S. A., Canga, A., Kırbaş, A., Yılmaz, A., Erdoğan, T., Akgül, O., Uğurlu, Y., & Durakoğlugil, M. E. (2013). Elevated serum YKL-40 level predicts myocardial reperfusion and in-hospital MACE in patients with STEMI. Herz, 38(2), 202–209. https://doi.org/10.1007/s00059-012-3671-4 | en_US |
dc.identifier.issn | 0340-9937 | |
dc.identifier.uri | https://doi.org/10.1007/s00059-012-3671-4 | |
dc.identifier.uri | https://hdl.handle.net/11436/4128 | |
dc.description | PubMed: 22955689 | en_US |
dc.description.abstract | Background: Macrophages in atherosclerotic plaques secrete YKL-40, a new biomarker of acute and chronic inflammation in patients with stable CAD. We hypothesized that YKL-40 may be a specific marker reflecting the burden of localized inflammation in myocardium and a predictor in patients with STEMI. In this study, we investigated the relationship of YKL-40 to in-hospital major adverse cardiac events (MACE), reperfusion parameters and its predictors in patients with STEMI. Methods: In total, 80 patients with STEMI and no history of prior coronary artery disease (CAD), who underwent primary percutaneous coronary intervention (p-PCI), were enrolled consecutively. In addition, 30 patients with normal coronary arteries (NCA) were enrolled as a control group. Cardiac biomarker levels including creatinine kinase-MB fraction (CK-MB), troponin-I, admission glucose and inflammatory markers including leukocytes and YKL-40 levels were measured as admission values. Results: In our study, YKL-40 levels correlated to high-sensitivity CRP levels (r = 0.333, p = 0.003), TIMI risk score (r = 0.445, p < 0.001), age (r = 0.477, p < 0.001), pain to balloon time (r = 0.432, p < 0.001), leukocyte and neutrophil count (r = 0.386, p < 0.001 and r = 0.430, p < 0.001, respectively), hemoglobin (r = - 0.345, p = 0.002), admission and fasting blood glucose (r = 0.388, p < 0.001 and r = 0.427, p < 0.001), creatinine levels (r = 0.395, p < 0.001) and myocardial blush grade (r = - 0.334, p = 0.004). When the patients were divided into two groups determined by presence or absence of MACE, the patients with MACE had significantly higher levels of YKL-40 in comparison to the patients without MACE and the control group (194 ± 104, 114 ± 61 and 110 ± 53 ?g/L, p < 0.001, respectively). In multivariate logistic regression analysis in STEMI patients, only YKL-40 level (OR: 1.011, 95%CI: 1.002-1.019, p = 0.011) and leukocyte count (OR: 1.264, 95%CI: 1.037-1.540, p = 0.020) were the independent predictors for MACE. Sensitivity and specificity of YKL-40 to predict MACE, when 125 ?g/l was accepted as a cut-off value, were 84% and 70%, respectively. Conclusion: We found that serum YKL-40 is related to older age, increased admission glucose levels, leukocyte counts and decreased hemoglobin levels; YKL-40 level and leukocyte count independently predicted MACE. © 2012 Urban & Vogel, Muenchen. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer Link | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Atherosclerosis | en_US |
dc.subject | C-reactive protein | en_US |
dc.subject | Major adverse cardiac events | en_US |
dc.subject | Myocardial reperfusion | en_US |
dc.subject | ST-segment elevation myocardial infarction | en_US |
dc.subject | YKL-40 | en_US |
dc.title | Elevated serum YKL-40 level predicts myocardial reperfusion and in-hospital MACE in patients with STEMI | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Çetin, Mustafa | |
dc.contributor.institutionauthor | Kocaman, Sinan Altan | |
dc.contributor.institutionauthor | Çanga, Aytun | |
dc.contributor.institutionauthor | Kırbaş, Aynur | |
dc.contributor.institutionauthor | Yılmaz, Adnan | |
dc.contributor.institutionauthor | Erdoğan, Turan | |
dc.contributor.institutionauthor | Uğurlu, Y. | |
dc.contributor.institutionauthor | Durakoğlugil, Murtaza Emre | |
dc.identifier.doi | 10.1007/s00059-012-3671-4 | |
dc.identifier.volume | 38 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 202 | en_US |
dc.identifier.endpage | 209 | en_US |
dc.relation.journal | Herz | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |