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dc.contributor.authorEkşi, Saliha
dc.contributor.authorEjder, Nebahat
dc.contributor.authorYılmaz, Fatih
dc.contributor.authorErtürk, Ayşe
dc.contributor.authorSandallı, Cemal
dc.date.accessioned2020-12-19T20:24:54Z
dc.date.available2020-12-19T20:24:54Z
dc.date.issued2016
dc.identifier.citationEkşi, S., Ejder, N., Yilmaz, F., Ertürk, A., & Sandalli, C. (2016). PaCaHa inhibits proliferation of human cancer cells in vitro. Turkish journal of medical sciences, 46(3), 872–876. https://doi.org/10.3906/sag-1503-142en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpRNE56ZzRPQT09
dc.identifier.urihttps://hdl.handle.net/11436/4925
dc.description.abstractBackground/aim: The aim of this study was to investigate the antiproliferative and cytotoxic effects of a newly synthesized molecule named paracetamol acetohydroxamic acid (PaCaHa) on human neoplastic cell lines. Materials and methods: A549, CRL 2923, HeLa, and ARPE were treated with various concentrations of PaCaHa and DMSO (vehicle control). The cytotoxic/cytostatic effects of PaCaHa were determined after a 24-h incubation period and compared to the DMSO control. The cytotoxic and antiproliferative effects were determined by the trypan blue dye exclusion and MTT methods. Results: A higher susceptibility to PaCaHA was found in CRL 2923 and HeLa cells, while A549 and ARPE cells were less responsive to PaCaHa. The percent of cytotoxicity resulting from 400 µg/mL of PaCaHa were >90 for CRL-2923 and HeLa, 68 for A549, and 64 for ARPE cells. The cytotoxic difference between CRL-2923/HeLa and ARPE/A549 cells was significant (P < 0.05). Conclusion: PaCaHa showed dose dependent cytotoxic and antiproliferative effects on three distinct human cancer cell lines. The differential effect of PaCaHa on different cancer cell lines suggests that PaCaHa could have a potential antitumor effect on specific cancer types. These results support further comprehensive studies on PaCaHa and its derivatives.en_US
dc.language.isootheren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.subjectParacetamol acetohydroxamic aciden_US
dc.subjectCanceren_US
dc.subjectMTTen_US
dc.subjectCRL-2923en_US
dc.subjectARPE-19en_US
dc.subjectA549en_US
dc.subjectHeLaen_US
dc.titlePaCaHa inhibits proliferation of human cancer cells in vitroen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorEkşi, Saliha
dc.contributor.institutionauthorEjder, Nebahat
dc.contributor.institutionauthorYılmaz, Fatih
dc.contributor.institutionauthorErtürk, Ayşe
dc.contributor.institutionauthorSandallı, Cemal
dc.identifier.volume46en_US
dc.identifier.issue3en_US
dc.identifier.startpage872en_US
dc.identifier.endpage876en_US
dc.ri.editoaen_US
dc.relation.journalTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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