dc.contributor.author | Akyüz, Gülay | |
dc.date.accessioned | 2022-09-23T07:42:25Z | |
dc.date.available | 2022-09-23T07:42:25Z | |
dc.date.issued | 2021 | en_US |
dc.identifier.citation | Akyuz, G. (2021). Synthesis and urease inhibition studies of some new quinazolinones. Journal of Heterocyclic Chemistry, 58(5), 1164-1170. https://doi.org/10.1002/jhet.4247 | en_US |
dc.identifier.issn | 0022-152X | |
dc.identifier.issn | 1943-5193 | |
dc.identifier.uri | https://doi.org/10.1002/jhet.4247 | |
dc.identifier.uri | https://hdl.handle.net/11436/6530 | |
dc.description.abstract | In this study, novel quinazolinones were designed, synthesized, characterized by FT-IR, H-1-NMR, C-13-NMR spectral data, and LC-MS. New compounds inhibitory activities on urease were assessed. All of the compounds exhibited potent urease inhibitory activities. Especially in the synthesized compounds, 2-benzyl-3-({5-[(4-nitrophenyl)amino]-1,3,4-thiadiazol2-yl}methyl)quinazolin-4(3H)-one has the best inhibitory effect against Jack bean urease with IC50 = 3.30 +/- 0.09 mu g/mL. And also, N-(4-nitrophenyl)-2-[(4-oxoquinazolin-3(4H)-yl)acetyl] hydrazinecarbothioamide, N-(4-fluorophenyl)-2-[(4-oxoquinazolin-3(4H)-yl)acetyl] hydrazinecarbothioamide, and 2-benzyl-3-({5-[(4-fluorophenyl)amino]-1,3,4-thiadiazol-2yl} methyl)quinazolin-4(3H)-one have best activities among the synthesized compounds. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.title | Synthesis and urease inhibition studies of some new quinazolinones | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.contributor.institutionauthor | Akyüz, Gülay | |
dc.identifier.doi | 10.1002/jhet.4247 | en_US |
dc.identifier.volume | 58 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 1164 | en_US |
dc.identifier.endpage | 1170 | en_US |
dc.relation.journal | Journal of Heterocyclic Chemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |