Basit öğe kaydını göster

dc.contributor.authorÇınar, Seda
dc.contributor.authorTümkaya, Levent
dc.contributor.authorMercantepe, Tolga
dc.contributor.authorSaral, Sinan
dc.contributor.authorRakıcı, Sema
dc.contributor.authorYılmaz, Adnan
dc.contributor.authorTopçu, Atilla
dc.contributor.authorŞen, Ahmet
dc.contributor.authorKarakaş, Sibel
dc.date.accessioned2022-10-16T14:52:22Z
dc.date.available2022-10-16T14:52:22Z
dc.date.issued2021en_US
dc.identifier.citationÇınar, S., Tümkaya, L., Mercantepe, T., Saral, S., Rakıcı, S., Yılmaz, A., Topçu, A., Şen, A., & Karakaş, S. (2021). Can Dexmedetomidine Be Effective in the Protection of Radiotherapy-Induced Brain Damage in the Rat?. Neurotoxicity research, 39(4), 1338–1351. https://doi.org/10.1007/s12640-021-00379-1en_US
dc.identifier.issn1029-8428
dc.identifier.issn1476-3524
dc.identifier.urihttps://doi.org/10.1007/s12640-021-00379-1
dc.identifier.urihttps://hdl.handle.net/11436/6755
dc.description.abstractApproximately 7 million people are reported to be undergoing radiotherapy (RT) at any one time in the world. However, it is still not possible to prevent damage to secondary organs that are off-target. This study, therefore, investigated the potential adverse effects of RT on the brain, using cognitive, histopathological, and biochemical methods, and the counteractive effect of the alpha 2-adrenergic receptor agonist dexmedetomidine. Thirty-two male Sprague Dawley rats aged 5-6 months were randomly allocated into four groups: untreated control, and RT, RT + dexmedetomidine-100, and RT + dexmedetomidine-200-treated groups. The passive avoidance test was applied to all groups. The RT groups received total body X-ray irradiation as a single dose of 8 Gy. The rats were sacrificed 24 h after X-ray irradiation, and following the application of the passive avoidance test. The brain tissues were subjected to histological and biochemical evaluation. No statistically significant difference was found between the control and RT groups in terms of passive avoidance outcomes and 8-hydroxy-2 '- deoxyguanosine (8-OHdG) positivity. In contrast, a significant increase in tissue MDA and GSH levels and positivity for TUNEL, TNF-alpha, and nNOS was observed between the control and the irradiation groups (p < 0.05). A significant decrease in these values was observed in the groups receiving dexmedetomidine. Compared with the control group, gradual elevation was determined in GSH levels in the RT group, followed by the RT + dexmedetomidine-100 and RT + dexmedetomidine-200 groups. Dexmedetomidine may be beneficial in countering the adverse effects of RT in the cerebral and hippocampal regions.en_US
dc.description.sponsorshipRecep Tayyip Erdogan University TU-2018-934en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDexmedetomidineen_US
dc.subjectRadiotherapyen_US
dc.subjectRaten_US
dc.subjectBrainen_US
dc.titleCan dexmedetomidine be effective in the protection of radiotherapy-induced brain damage in the rat?en_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.identifier.doi10.1007/s12640-021-00379-1
dc.identifier.volume39en_US
dc.identifier.issue4en_US
dc.identifier.startpage1338en_US
dc.identifier.endpage1351en_US
dc.relation.journalNeurotoxicity Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Bu öğenin dosyaları:

Thumbnail

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster