Ara
Toplam kayıt 46, listelenen: 31-40
Design, synthesis, and biological evaluation of coumarin-triazole hybrid molecules as potential antitumor and pancreatic lipase agents
(Wiley-V C H Verlag Gmbh, 2017)
The design, synthesis, and investigation of antitumor and anti-lipase activities of some coumarin-triazole hybrid molecules are reported. the synthesis of these hybrid molecules was performed under microwave irradiation ...
Synthesis and molecular docking study of some 5,6-dichloro-2cyclopropyl-1H-benzimidazole derivatives bearing triazole, oxadiazole, and imine functionalities as potent inhibitors of urease
(Pergamon-Elsevier Science Ltd, 2017)
A new series of benzimidazole compounds including hydrazinecarbothioamide, 1,2,4-triazole, 1,3,4-oxadiazole and imine function were synthesized starting from 5,6-dichloro-2-cyclopropyl-1H-benzimidazole. All of the benzimidazole ...
Microwave-assisted synthesis of benzimidazoles and their derivatives from 1994 to 2016-A review
(Bentham Science Publ Ltd, 2017)
Background: the use of microwave irradiation is an important development for the synthesis of benzimidazoles in the 21st century, and in recent years, microwave-assisted heterocyclic synthesis has gained significant attention ...
Synthesis and antimicrobial activity of some new triazole bridged benzimidazole substituted phthalonitrile and phthalocyanines
(Editura Acad Romane, 2018)
In this study, some new phthalonitriles and metallophthalocyanines (Zn, Ni, Co, and Cu) containing triazole bridged benzimidazole moieties were synthesized starting from 2-(3-methylbenzyl)-1H-benzimidazole Newly synthesized ...
Microwave assisted synthesis of cournarins: A review from 2007 to 2018
(Bentham Science Publ Ltd, 2018)
Background: Microwave heating has been shown to be an invaluable technology for medicinal chemistry and drug discovery applications. Recently, it has been used for heterocyclic synthesis increasingly. This review article ...
Synthesis, molecular docking and biological evaluation of some benzimidazole derivatives as potent pancreatic lipase inhibitors
(Academic Press Inc Elsevier Science, 2018)
In this study, a new series of benzimidazole and bisbenzimidazole derivatives were prepared via the reaction of iminoester hydrochlorides and o-phenylenediamines and then screened for their lipase inhibition properties. ...
Synthesis of novel 2,3-disubstituted quinazolin-4(3H)-one derivatives containing hydrazone skeleton as potent urease inhibitors and their antimicrobial activities
(Wiley, 2019)
A new series of quinazolinones containing hydrazone moiety were synthesized, and their inhibitory activities on urease were assessed in vitro. Most of the compounds exhibited potent urease inhibitory activity. Among the ...
Synthesis, inhibitory properties on the metabolic enzymes and antioxidant activity of a new series benzimidazole derivatives
(Editura Acad Romane, 2019)
In this study, a series of new 1, 2-disubstituted benzimidazole was synthesized starting from 5, 6-dichloro-2-(4-methoxybenzyl)-1H-benzimidazole compound which was converted to the ester and hydrazide derivative, respectively. ...
Microwave-assisted synthesis of novel 2,4-dihydro-5-[4-(trifluoromethyl) phenyl]-3h-1,2,4-triazol-3-ones and potentiometric determination of their pKa in nonaqueous solvents
(Wiley, 2010)
The novel 4-amino- or 4-aryl-substituted 2,4-dihydro-5-[(4-trifluoromethyl) phenyl]-3H-1,2,4-triazol-3-ones 3a-3g were synthesized by reaction of N-(ethoxycarbonyl)-4-(trifluoromethyl)benzenehydrazonic acid ethyl ester (2) ...
Determination of the pKa of Some triazole derivatives by the potentiometric method in dioxan-water mixtures
(2011)
Stoichiometric protonation constants of some 3-alkyl(aryl)-4-(substituted benzylamino)-4,5-dihydro-1 H-1,2,4-triazol-5-ones derivatives were determined potentiometrically in 50% (v/v) dioxan-water mixtures at 25°C with an ...