Urease inhibition studies of new benzimidazoles containing triazole ring

Abstract

A new series of benzimidazoles including triazole and thiosemicarbazide moieties was synthesized and their urease inhibition studies were evaluated according to the method of Van Slyke and Archibald. Especially triazole derivatives have effective inhibition activities between 0.04 +/- 0.026 and 0.26 +/- 0.042 mu M IC50 values. The best antiurease activities with IC50 0.04 +/- 0.026 and 0.06 +/- 0.033 mu M belongs to 5-[(5,6-dichloro-1H-benzimidazol-1-yl)methyl]-4-nitrophenyl-4H-1,2,4-triazole-3-thiol and 2-[(2-benzyl-5,6-dichloro-1H-benzimidazol-1-yl)acetyl]-N-(4-nitrophenyl)hydrazinecarbothioamide, respectively.