Chlorogenic acid attenuates cisplatin-induced ovarian injury in rats

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Date

2023

Author

Demir, Elif Ayazoğlu
Menteşe, Ahmet
Livaoğlu, Ayten
Alemdar, Nihal Türkmen
Aliyazıcıoğlu, Yüksel
Demir, Selim

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Ayazoglu Demir, E., Mentese, A., Livaoglu, A., Turkmen Alemdar, N., Aliyazicioglu, Y., & Demir, S. (2023). Chlorogenic acid attenuates cisplatin-induced ovarian injury in rats. Drug and chemical toxicology, 1–5. Advance online publication. https://doi.org/10.1080/01480545.2023.2172181

Abstract

The aim of this study was to determine the possible therapeutic effect of chlorogenic acid (CGA) on cisplatin (CDDP)-induced ovarian damage in rats. Rats were first exposed to CDDP (5 mg/kg) and then treated CGA (1.5 and 3 mg/kg) for three days. Oxidative stress (OS), inflammation and apoptosis markers were determined using spectrophotometric methods. Ovarian tissues were also evaluated histologically. The levels of OS, inflammation and apoptosis biomarkers increased by CDDP administration (p < 0.05). Treatments with CGA significantly alleviated these markers dose-dependently (p < 0.05). These data reveal that CGA may exert an ovoprotective effect by reducing pro-inflammatory mediators and enhancing antioxidant status in ovarian tissue.

Source

Drug and Chemical Toxicology

URI

https://doi.org/10.1080/01480545.2023.2172181
https://hdl.handle.net/11436/8261

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