Kurum Yazarı "Tümkaya, Levent" Scopus İndeksli Yayınlar Koleksiyonu İçin Listeleme
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Effects of infliximab against carbon tetrachloride-induced intestinal injury via lipid peroxidation and apoptosis
Pergel, Ahmet; Tümkaya, Levent; Çolakoğlu, Muhammed Kadri; Demiral, Gökhan; Kalcan, Süleyman; Özdemir, Ali; Mercantepe, Tolga; Yılmaz, Adnan (Sage Publications Ltd, 2019)Carbon tetrachloride (CCL4) is often employed in the production of chlorofluorocarbons, petroleum refining, oil and rubber processing, and laboratory applications. Oral, subcutaneous, and inhalation exposure to CCL4 in ... -
Effects of infliximab against carbon tetrachloride-induced spleen toxicity in rats
Bahçeci, İlkay; Tümkaya, Levent; Mercantepe, Tolga; Yılmaz, H.; İbik, Y.E.; Duran, Ömer Faruk; Arslan, Nurgül (Verduci Publisher, 2023)OBJECTIVE: Carbon tetrachloride (CCl4 ) is a non-polar molecule used in industry in grain curing, insect-killing and especially in the production of chlorofluorocarbons. It is estimated that an average of 70,000 industry ... -
Effects of infliximab against methotrexate toxicity in splenic tissue via the regulation of CD3, CD68, and C200R in rats
Mercantepe, Tolga; Tümkaya, Levent; Mercantepe, Filiz (Karger, 2018)Methotrexate (MTX), which has been used in clinical practice for approximately 70 years, is still widely employed in the treatment of rheumatoid arthritis (RA), psoriasis, and cancer. Although MTX toxicity causes nephrotoxicity, ... -
The effects of infliximab on laminin, NF kappa B, and Anti-TNF expression through Its effect on ischemic liver tissue
Akdoğan, Remzi Adnan; Kalkan, Yıldıray; Tümkaya, Levent; Rakıcı, Halil; Akdoğan, Elif (Hindawi Ltd, 2016)The aim of this study was to investigate the possible protective effects of infliximab on expression of laminin, anti-TNF, and NF kappa B in the rat hepatic cells after ischemia/reperfusion (I/R). A total of 30 male Wistar ... -
The effects of long-term doppler ultrasound exposure in the prenatal period on renal tissue physiology in rats
Çeliker, Fatma Beyazal; Tümkaya, Levent; Mercantepe, Tolga; Zengin, Ertan; Beyazal, Mehmet; Turan, Arzu; Polat, Hatice Beyazal; Suzan, Zehra Topal; Yılmaz, Adnan (Taylor & Francis Inc., 2022)Doppler ultrasonography (DUSG) is widely used for fetal evaluations. This study investigated the effects of new generation Doppler ultrasound application at different frequencies during pregnancy on postnatal renal ... -
Effects of long-term Doppler ultrasound exposure on cochlea and cochlear nucleus in prenatal period in an experimental model
Çeliker, Metin; Beyazal Çeliker, Fatma; Tümkaya, Levent; Oğhan, Fatih; Özgür, Abdulkadir; Mercantepe, Tolga; Terzi, Suat; Beyazal, Mehmet; Turan, Arzu; Çınar, Seda; Zengin, Ertan; Demir, Emine; Dursun, Engin (Taylor & Francis Ltd., 2021)Background New generation Doppler ultrasonography (DUSG) application effects on cochlea and cochlear nucleus (CN) are unclear. We aimed to investigate the effects of new generation DUSG application at different frequencies ... -
The effects of mobile phone exposure on mast cells in rat dura mater
Tümkaya, Levent; Kalkan, Yıldıray; Gökçe, Fatih Mehmet; Erdivanlı, Başar; Yılmaz, Adnan; Bahçeci, İlkay; Yazıcı, Zihni Açar; Mercantepe, Tolga (Soc Chilena Anatomia, 2019)Mobile phone use has increased rapidly. the central nervous system has been shown to be adversely affected by its electromagnetic field (EMF) resulting in headache and sleep disturbances. How the cells make up the CNS and ... -
The effects of N-acetylcysteine on radiotherapy-induced small intestinal damage in rats
Mercantepe, Filiz; Topçu, Atilla; Rakıcı, Sema; Tümkaya, Levent; Yılmaz, Adnan (Sage Publications Ltd, 2019)Six million cancer patients worldwide receive radiotherapy, either alone or in combination with other cancer treatments annually. the purpose of this study was to investigate, at the structural and molecular levels, the ... -
Effects of sugammadex and rocuronium mast cell number and degranulation in rat liver
Tomak, Yakup; Yılmaz, Adnan; Bostan, Habib; Tümkaya, Levent; Altuner, Durdu; Kalkan, Yıldıray; Erdivablı, Başar (Wiley, 2012)We investigated the effect of rocuronium- and sugammadex-induced mast cell increase and degranulation in rat portal triads. Forty-two rats, in six groups, received either rocuronium 1 mg.kg -1; sugammadex 15 mg.kg -1; ... -
Effects of sugammadex on immunoreactivity of calcineurin in rat testes cells after neuromuscular block: A pilot study
Kalkan, Yıldıray; Tümkaya, Levent; Bostan, Habib; Tomak, Yakup; Yılmaz, Adnan (Springer, 2012)Reversal of neuromuscular blockage induced by steroidal neuromuscular blocking agents such as rocuronium can be achieved using normal dose of sugammadex, which has been shown to be very effective for such reversal. In this ... -
The effects of TNF-alpha inhibitors on carbon tetrachloride-induced nephrotoxicity
Özdemir, Ali; Tümkaya, Levent; Kalcan, Süleyman; Uyan, Mikail; Karakaya, Ahmet; Demiral, Gökhan; Samancı, Tuğba Çelik; Mercantepe, Tolga; Cüre, Medine Cumhur; Cüre, Erkan (Taylo & Francis Ltd., 2021)Objectives: Carbon tetrachloride (CCl4), employed in various industrial fields, can cause acute damage in renal tissues. This study investigated the therapeutic effect of the TNF-alpha inhibitor Infliximab on TGF-beta and ... -
Evaluation of the effects of dexmedetomidine on liver damage secondary to renal ischemia-reperfusion
Kartal, Seyfi; Şen, Ahmet; Tümkaya, Levent; Abdullah, Özdemir; Tolga, Mercantepe; Adnan, Yılmaz (Anaesthesia Pain & Intensive Care, 2020)Background: the aim of this study was to evaluate the hepatic protective effects of dexmedetomidine in a rat model of renal ischemia-reperfusion (I/R) injury. Methodology: We selected 18 albino rats and randomly divided ... -
Evaluation of the protective effect of coenzyme Q10 against x-ray irradiation-induced ovarian injury
Tekin, Yeşim Bayoğlu; Tümkaya, Levent; Mercantepe, Tolga; Topal, Zehra Suzan; Samancı, Tuğba Çelik; Yılmaz, Hülya Kılıç; Rakıcı, Sema Yılmaz; Topçu, Atilla (Wiley, 2024)Aim: This study focused on the anti-oxidant and anti-apoptotic effects of CoQ10 in ovaries exposed to pelvic radiation. Methods: Thirty-two female rats were randomly assigned into four groups. Group I (control group), Group ... -
Evaluation of the protective effects of amifostine and melatonin against cisplatin induced testis injury via oxidative stress and apoptosis in rats
Eren, Hüseyin; Mercantepe, Tolga; Tümkaya, Levent; Mercantepe, Filiz; Dil, Eyüp; Horsanali, Mustafa Ozan; Yılmaz, Adnan (Academic Press Inc Elsevier Science, 2020)..... -
Gene expression and histopathological evaluation of thiamine pyrophosphate on optic neuropathy induced with ethambutol in rats
Çinici, Emile; Çetin, Nihal; Süleyman, Bahadır; Altuner, Durdu; Yaralı, Oğuzhan; Balta, Hilal; Çalık, İlknur; Tümkaya, Levent; Süleyman, Halis (Ijo Press, 2016)AIM: To compare the effects of thiamine pyrophosphate (TPP) and thiamine (TM) in oxidative optic neuropathy in rats induced by ethambutol. METHODS: the animals were divided into four groups: a control group (CG), an ... -
Grading of epidural fibrosis in a new rabbit experimental model for epidural adhesive scar tissue formation
This experimental study was planned to evaluate the success of rabbit hemilaminotomy procedure and proposing of a new grading system in the evaluation of epidural fibrosis. Fourteen New Zealand white rabbits were used in ... -
Hepatic effects of ketamine administration for 2 weeks in rats
Kalkan, Yıldıray; Tomak, Yakup; Altuner, Durdu; Tümkaya, Levent; Bostan, Habib; Yılmaz, Adnan; Ünal, D.; Kara, A.; Turan, A. (Sage Publishing, 2014)The aim of the present study was to investigate the long-term and high-dose application of ketamine on the liver by employing histologic and biochemical methods. A total of 30 male rats were randomly assigned to control ... -
The hepatoprotective potential of resveratrol in an experimental model of ruptured abdominal aortic aneurysm via oxidative stress and apoptosis
Bilen, Arzu; Mercantepe, Filiz; Tümkaya, Levent; Yılmaz, Adnan; Batçık, Şule (Wiley, 2021)The mortality rate in ruptured abdominal aortic aneurysms can today be reduced through cardiovascular surgery. However, ischemia and reperfusion-induced tissue damage develop due to aortic cross-clamping applied during ... -
High dose zoledronic acid increases ischemia-reperfusion damage of the liver
Aydın, İbrahim; Şehitoğlu, İbrahim; Özer, Emel; Kalkan, Yıldıray; Tümkaya, Levent; Cüre, Medine Cumhur; Cüre, Erkan (Verduci Publisher, 2021)OBJECTIVE: Zoledronic acid (ZA), a nitrogen-containing bisphosphonate, has been reported to exhibit a protective effect against cancers and prevent bone fractures. It also induces apoptosis by increasing proinflammatory ... -
Histopathological evaluation of the effects of dexmedetomidine against pituitary damage ınduced by X-ray irradiation
Mercantepe, Filiz; Tümkaya, Levent; Mercantepe, Tolga; Rakıcı, Sema (Taylor & Francis Ltd., 2022)Background: The present study, aimed to investigate the potential negative effects of x-ray radiation and the effects of the α2-adrenergic receptor agonist dexmedetomidine on the pituitary gland. Methods: Twenty-four ...