Browsing PubMed İndeksli Yayınlar Koleksiyonu by Author "RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü"
Now showing items 1-20 of 82
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4-Amino-3,5-diethyl-4H-1,2,4-triazole at 100 K: Chains of edge-fused R 44(10) and R44(20) rings
Şahin, Onur; Büyükgüngör, Orhan; Şaşmaz, Selami; Gümrükçüoğlu, Nurhan; Kantar, Cihan (Wiley, 2007)The title compound, C6H12N4, has four crystallographically independent mol-ecules in the asymmetric unit. Inter-molecular N - H?N hydrogen bonds involving amino groups and triazole N atoms form a three-dimensional framework ... -
Anticancer evaluation of a manganese complex on HeLa and MCF-7 cancer cells: design, deterministic solvothermal synthesis approach, Hirshfeld analysis, DNA binding, intracellular reactive oxygen species production, electrochemical characterization and density functional theory
Abbas, Saghir; Rashid, Faisal; Ülker, Emine; Zaib, Sumera; Ayub, Khurshid; Ullah, Sana; Nadeem, Muhammad Arif; Yousuf, Sammer; Ludwig, Ralf; Ali, Saqid; Iqbal, Jamshed (Taylor & Francis Inc, 2020)Herein, a deterministic solvothermal strategy was employed to synthesize an efficient anticancer agent 'cis-dichlorobis(1,10-phenanthroline)manganese(II)' (Mn(phen)(2)Cl-2). A single-crystal X-ray diffraction analysis ... -
Benzimidazolone-piperazine/triazole/thiadiazole/furan/thiophene conjugates: Synthesis, in vitro urease inhibition, and in silico molecular docking studies
Güven, Okan; Menteşe, Emre; Emirik, Mustafa; Sökmen, Bahar Bilgin; Akyüz, Gülay (Wiley, 2023)This study describes the synthesis, in vitro urease inhibition, and molecular docking studies of benzimidazolone derivatives incorporating the piperazine, triazole, thiadiazole, furan, thiophene, and thiosemicarbazide ... -
Bioevaluation of synthetic pyridones as dual inhibitors of alpha-amylase and alpha-glucosidase enzymes and potential antioxidants
Saleem, Faiza; Khan, Khalid Mohammed; Ullah, Nisar; Özil, Musa; Baltaş, Nimet; Hameed, Shehryar; Salar, Uzma; Wadood, Abdul; Rehman, Ashfaq Ur; Kumar, Mukesh; Taha, Muhammad; Haider, Syed Moazzam (Wiley, 2022)Herein, a library of novel pyridone derivatives 1-34 was designed, synthesized, and evaluated for alpha-amylase and alpha-glucosidase inhibitory as well as antioxidant activities. Pyridone derivatives 1-34 were synthesized ... -
The cardioprotective mechanism of phenylaminoethyl selenides (PAESe) against doxorubicin-Induced cardiotoxicity involves frataxin
Fu, Xiaoyu; Eggert, Mathew; Yoo, Sieun; Patel, Nikhi; Zhong, Juming; Steinke, Ian; Govindarajulu, Manoj; Turumtay, Emine Akyüz; Mouli, Shravanthi; Panizzi, Peter; Beyers, Ronald; Denney, Thomas; Arnold, Robert; Amin, Rajesh H. (Frontiers Media, 2021)Doxorubicin (DOX) is an anthracycline cancer chemotherapeutic that exhibits cumulative dose-limiting cardiotoxicity and limits its clinical utility. DOX treatment results in the development of morbid cardiac hypertrophy ... -
Cellulose ester-based aerogel: lightweight and highly water-absorbent
Aksu, Kadir; Kaya, Mehmet (American Chemical Society, 2023)Cellulose was extracted from waste generated by pruning tea stem wastes. The interaction between pure cellulose and homophthalic acid produced a light (0.22 g·cm-3) and eco-friendly hybrid aerogel product that is highly ... -
Characterization and inhibition studies of carbonic anhydrase from gill of Russian Sturgeon Fish (Acipenser gueldenstaedtii)
Dincer, Barbaros; Ekinci, Arife Pınar; Akyüz, Gülay; Kurtoğlu, İlker Zeki (Taylor & Francis Ltd, 2016)An alpha-carbonic anhydrase (CA, EC 4.2.1.1) was purified and characterized kinetically from gill of Acipenser gueldenstaedtii as an endangered sturgeon species. the carbonic anhydrase was purified 66-folds with yield 20.7% ... -
Characterization and pillaring of a Turkish bentonite (Resadiye)
Tabak, Ahmet; Afsin, B.; Çağlar, B.; Köksal, E. (Elsevier, 2007)The shifts of the Si{single bond}O{single bond}Si stretching and the Si{single bond}O{single bond}Al and Si{single bond}O{single bond}Si bending modes, as well as the free silica peak in the IR spectra and the strengthening ... -
Chemical variation, antimicrobial, nitric oxide scavenging activities and tyrosinase inhibition of essential oils and solvent extracts from filipendula vulgaris moench growing in Turkey
Fandaklı, Seda; Korkmaz, Büşra; Faiz, Özlem; Kılıç, Gözde; Erik, İshak; Terzioğlu, Salih; Yaylı, Nurettin (Shaheed Beheshti University, 2021)Volatile organic compositions of the essential oils (EOs), solid-phase microextraction (SPME) and SPME of n-hexane extracts from the flower and stem-leaf of Filipendula vulgaris (F. vulgaris) were analyzed by GC-FID/MS. A ... -
Computational studies on the anastrozole and letrozole, effective chemotherapy drugs against breast cancer
Akçay, Hakkı Türker; Bayrak, Rıza (Pergamon-Elsevier Science Ltd, 2014)In this paper, computational studies were carried out on anastrozole and letrozole, chemotherapy drugs used against breast cancer. Optimization and frequency calculations were performed at B3LYP/6-31G (d) basis set and ... -
Design and synthesis of benzimidazole derivatives as apoptosis-inducing agents by targeting Bcl-2 protein
İlhan, Süleyman; Çamlı Pulat, Çisil; Oğuz, Ferdi; Bektaş, Hakan; Menteşe, Emre; Atmaca, Harika (Springer, 2022)Bcl-2, an anti-apoptotic protein, is a well-known and appealing cancer therapy target. Novel series of benzimidazole derivatives were synthesized and tested for their activity as Bcl-2 inhibitors on T98G glioblastoma, PC3 ... -
Design, molecular docking and synthesis of novel 5,6-dichloro-2-methyl-1H-benzimidazole derivatives as potential urease enzyme inhibitors
Menteşe, Emre; Emirik, Mustafa; Sökmen, Bahar Bilgin (Academic Press Inc Elsevier Science, 2019)A novel series of 5,6-dichloro-2-methyl-1H-benzimidazole derivatives was synthesized and then screened for their urease inhibitory activity. All compounds showed more potent inhibitory activity in the range of IC50= 0.0294 ... -
Design, synthesis and biological evaluation of water soluble and non-aggregated silicon phthalocyanines, naphthalocyanines against A549, SNU-398, SK-MEL128, DU-145, BT-20 and HFC cell lines as potential anticancer agents
Keleş, Turgut; Barut, Burak; Özel, Arzu; Bıyıklıoğlu, Zekeriya (Elsevier, 2021)Cancer has become an important public problem in worldwide since cancer incidence and mortality are growing rapidly. In this study, water soluble and non-aggregated silicon (IV) phthalocyanines and naphthalocyanines ... -
Design, synthesis, and biological evaluation of coumarin-triazole hybrid molecules as potential antitumor and pancreatic lipase agents
Kahveci, Bahittin; Yılmaz, Fatih; Menteşe, Emre; Ülker, Serdar (Wiley-V C H Verlag Gmbh, 2017)The design, synthesis, and investigation of antitumor and anti-lipase activities of some coumarin-triazole hybrid molecules are reported. the synthesis of these hybrid molecules was performed under microwave irradiation ... -
Determination of color additive tartrazine (E 102) in food samples after dispersive solid phase extraction with a zirconium-based metal-organic framework (UiO-66(Zr)-(COOH)(2))
Oymak, Tülay; Tokalıoğlu, Şerife; Cam, Şafak; Demir, Selçuk (Taylor & Francis Ltd, 2020)A new and rapid dispersive solid phase extraction method by using a green-synthesised UiO-66(Zr)-(COOH)(2) (Zr-BTeC) adsorbent with body-centred cubic (bcu) topology was developed for determination of tartrazine in food ... -
Developing a scaffold for urease inhibition based on benzothiazoles: Synthesis, docking analysis, and therapeutic potential
Özil, Musa; Tuzcuoğlu, Özge; Emirik, Mustafa; Baltaş, Nimet (Wiley-V C Verlag GMBH, 2021)The synthesis, in silico molecular docking, and in vitro urease inhibition studies of a novel series of benzothiazole derivatives are reported. The title compounds in the two series, namely, 2-({5-[(benzothiazol-2-ylthio ... -
Effect of propolis in gastric disorders: inhibition studies on the growth of Helicobacter pylori and production of its urease
Baltaş, Nimet; Karaoğlu, Şengül Alpay; Tarakcı, Cemre; Kolaylı, Sevgi (Taylor & Francis Ltd, 2016)There is considerable interest in alternative approaches to inhibit Helicobacter pylori (H. pylori) and thus treat many stomach diseases. Propolis is a pharmaceutical mixture containing many natural bioactive substances. ... -
Effect of Usnea longissima ethyl acetate extract on acute oxidative and inflammatory lung damage from Staphylococcus aureus infection in rats
Dabanlıoğlu, Bülent; Süleyman, Bahadır; Mammadov, Renad; Yavuzer, Bülent; Akyüz, Sümeyey; Akkaş, Önder; Mokhtare, Behzad; Turumtay, Emine Akyüz; Altuner, Durdu; Çoban, Taha Abdulkadir; Süleyman, Halis (University of South Bohemia in Ceske Budejovice Faculty of Health and Social Sciences, 2023)The role of oxidants and proinflammatory cytokines in the pathogenesis of pneumonia caused by Staphylococcus aureus (S. aureus) has been demonstrated. The present study aims to investigate the protective effect of ethyl ... -
Efficient, rapid, and high-yield synthesis of aryl Schiff base derivatives and their in vitro and in silico inhibition studies of hCA I, hCA II, AChE, and BuChE
Özil, Musa; Balaydın, Halis T.; Doğan, Berna; Şentürk, Murat; Durdağı, Serdar (Wiley, 2024)This study reports a rapid and efficient synthesis of four novel aryl Schiff base derivatives. Biological activity and molecular modeling studies were conducted to evaluate the inhibitory effects of these compounds on human ... -
The electrochemical and spectroelectrochemical properties of metal free and metallophthalocyanines containing triazole/piperazine units
Demirbaş, Ümit; Akyüz, Duygu; Mermer, Arif; Akçay, Hakkı Türker; Demirbaş, Neslihan; Koca, Atıf; Kantekin, Halit (Pergamon-Elsevier Science Ltd, 2016)The synthesis and characterization of novel peripherally tetra [1,2,4]-triazole substituted metal-free phthalocyanine and its metal complexes (Zn(II), Ni(II), Pb(II), Cu(II) and Fe(II)) and the investigation of electrochemical ...