Yazar "RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü" için FEF, Biyoloji Bölümü Koleksiyonu listeleme
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Microwave-assisted synthesis of some new coumarin derivatives including 1,2,4-triazol-3-one and investigation of their biological activities
Kahveci, Bahittin; Yılmaz, Fatih; Menteşe, Emre; Ülker, Serdar (Springer, 2015)By using the microwave technology, a new protocol has been developed for the synthesis of new coumarin derivatives including 1,2,4-triazol-3-one skeleton. This protocol proves to be efficient and environmentally friendly ... -
Microwave-assisted synthesis of some novel benzimidazole derivatives containing imine function and evaluation of their antimicrobial activity
Kahveci, Bahittin; Yılmaz, Fatih; Menteşe, Emre; Özil, Musa; Karaoğlu, Şengül Alpay (Wiley, 2014)4-Bromo-o-phenylenediamine and ethylimido-p-bromophenylacetate, 1, were subjected to microwave irradiation to synthesize benzimidazole derivative, compound 2. Ester derivative, 3, and hydrazide derivative, 4, of compound ... -
Microwave-promoted synthesis and biological activity of some 2-hetarylmethyl-4-(4-hetarylphenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one derivatives
Özil, Musa; Bodur, Osman; Ülker, Serdar; Kahveci, Bahittin (Springer, 2015)A series of fused and non-fused 1,2,4-triazole derivatives were prepared starting from ethyl 4-[1-(2-ethoxy-2-oxoethyl)-3-methyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]benzoate. Firstly, both ethyl ester groups were ... -
Molecular docking studies and synthesis of novel bisbenzimidazole derivatives as inhibitors of alpha-glucosidase
Özil, Musa; Emirik, Mustafa; Beldüz, Ali; Ülker, Serdar (Pergamon-Elsevier Science Ltd, 2016)A series of bisbenzimidazole derivatives starting from o-phenylenediamine and 4-nitro-o-phenylenediamine were prepared with oxalic acid. Most of the reactions were conducted using both the microwave and conventional methods ... -
New potential monotherapeutic candidates for helicobacter pylori: Some pyridinazo compounds having both urease enzyme inhibition and anti-helicobacter pylori effectiveness
Kantar, Cihan; Baltaş, Nimet; Karaoğlu, Şengül Alpay; Şaşmaz, Selami (Springer, 2021)To contribute to the monotherapeutic approach to Helicobacter pylori, some new pyridinazo compounds containing natural phenols such as eugenol and guaiacol were synthesized and their antioxidant capacities, urease enzyme ... -
Paeoniflorigenone purified from Paeonia daurica roots potently inhibits viral and bacterial DNA polymerases: investigation by experimental validation and docking simulation
Demir, Adem; Turumtay, Halbay; Emirik, Mustafa; SandalIı, Cemal; Kanbolat, Şeyda; Özgen, Ufuk; Turumtay, Emine Akyüz (Springer Birkhauser, 2019)The methanolic extracts from fruit, leaf, stem and roots of Paeonia daurica subsp. macrophylla (P. daurica) were investigated for inhibitory effect on replicative bacterial (PolC and DnaE2) and viral (MMLV-RT from Moloney ... -
Rapid and efficient microwave-assisted synthesis of some new triazol-3-one derivatives
Menteşe, Emre; Özil, Musa; Karaoğlu, Şengül Alpay; Kahveci, Bahittin (Wiley, 2013)A growing body of literature has shown the effectiveness of using microwaves in chemical reactions. The aim of this study is to demonstrate a rapid and highly efficient synthesis of some new triazol-3-ones via microwave ... -
Rapid synthesis and lipase inhibition activity of some new benzimidazole and perimidine derivatives
Menteşe, Emre; Yılmaz, Fatih; Karaali, Nesrin; Ülker, Serdar; Kahveci, Bahittin (Maik Nauka/Interperiodica/Springer, 2014)This study presents a synthesis of new series of some benzimidazole, bisbenzimidazole and perimidine derivatives via microwave technique, which, leads to the good product yields and short reaction times. the structure of ... -
A simple and efficient synthesis of novel inhibitors of alpha-glucosidase based on benzimidazole skeleton and molecular docking studies
Özil, Musa; Emirik, Mustafa; Etlik, Semiha Yılmaz; Ülker, Serdar; Kahveci, Bahittin (Academic Press Inc Elsevier Science, 2016)A novel series of benzimidazole derivatives were prepared starting from o-phenylenediamine and 4-nitro-o-phenylenediamine with iminoester hydrochlorides. Acidic proton in benzimidazole was exchanged with ethyl bromoacetate, ... -
Some azo dyes containing eugenol and guaiacol, synthesis, antioxidant capacity, urease inhibitory properties and anti-helicobacter pylori activity
Kantar, Cihan; Baltaş, Nimet; Karaoğlu, Şengül Alpay; Şaşmaz, Selami (Editura Acad Romane, 2018)There are many studies about azo compounds at literature. However, antioxidant capacity, urease inhibitory and anti-Helicobacter pylori activity properties are not well known. Therefore, some azo dyes containing eugenol ... -
Some schiff bases containing eugenol and guaiacol: Comparison of urease inhibition and anti-helicobacter pylori activities with Its azo analogs
Kantar, Cihan; Baltaş, Nimet; Karaoğlu, Şengül Alpay; Şaşmaz, Selami (Springer, 2024)To improve and develop our monotherapeutic approach for Helicobacter pylori infection, some Schiff base compounds containing eugenol and guaiacol were synthesized and their antioxidant capacities, urease enzyme inhibition, ... -
Study of antıoxidant, antimicrobial and anti-xanthine oxidase activities of some 5,6-dimethyl-2-(substituted)-1h-benzimidazoles and their acylhydrazide derivatives
Baltaş, Nimet; Beriş, Fatih Şaban; Menteşe, Emre (Raman Publ, 2017)In this study, a series of 5,6-dimethy1-2-(4-fluoro/chloro/bromo/methyl/nitrobenzy1)-1Hbenzimidazoles were screened for their bovine milk xanthine oxidase (XO) inhibition, antioxidant and antimicrobial activities. Compounds ... -
Synthesis and antimicrobial activity of some new triazole bridged benzimidazole substituted phthalonitrile and phthalocyanines
Kantar, Günay Kaya; Menteşe, Emre; Beriş, Fatih Şaban; Şaşmaz, Selami; Kahveci, Bahittin (Editura Acad Romane, 2018)In this study, some new phthalonitriles and metallophthalocyanines (Zn, Ni, Co, and Cu) containing triazole bridged benzimidazole moieties were synthesized starting from 2-(3-methylbenzyl)-1H-benzimidazole Newly synthesized ... -
Synthesis and antimicrobial properties of N-substituted derivatives of (E)-2 ',3 ''-thiazachalcones
Usta, Asu; Taşkıran, Hacer (Walter de Gruyter Gmbh, 2015)N-alkyl substituted 2',3 ''-thiazachalcones {3-[(1E)-3-(4-methylthiophene-2-yl)-3-oxoprop-1-en-1-yl]-1-alkyl (C-5-12,C-14) pyridinium bromides} were synthesized by a two-step reaction. the newly synthesized compounds were ... -
Synthesis and evaluation of alpha-glucosidase and pancreatic lipase inhibition by quinazolinone-coumarin hybrids
Menteşe, Emre; Karaali, Nesrin; Akyüz, Gülay; Yılmaz, Fatih; Ülker, Serdar; Kahveci, Bahittin (Springer, 2016)A new series of 2-substituted quinazolin-4(3H)-one derivatives including coumarin nucleus has been synthesized and screened for their lipase and a-glucosidase inhibition properties. Among the synthesized compounds, ... -
Synthesis and pharmacological activities of some new 2-[1-Heptyl-3-(4-methoxybenzyl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl] acetohydrazide derivatives
Bekircan, Olcay; Menteşe, Emre; Ülker, Serdar (Walter de Gruyter Gmbh, 2014)In the present investigation, the key intermediate acetohydrazide derivative 5 was synthesized starting from 3-(4-methoxybenzyl)-4-amino-4,5-dihydro-1,2,4-triazol-5-one (1) by a four-step reaction. Thiosemicarbazides 6a-f ... -
Synthesis and study of alpha-glucosidase inhibitory, antimicrobial and antioxidant activities of some benzimidazole derivatives containing triazole, thiadiazole, oxadiazole, and morpholine rings
Menteşe, Emre; Ülker, Serdar; Kahveci, Bahittin (Springer, 2015)A new series of 2-(4-bromobenzyl)- and 2-(4-fluorobenzyl)-1H-benzimidazole derivatives containing 1,2,4-triazole, 1,3,4-thiadiazole, 1,3,4-oxadiazole, and morpholine rings has been synthesized. the structures of the newly ... -
Synthesis of methyl (E)-2′,4″-thiazachalcones and their N-alkyl derivatives, photochemistry with theoretical calculations and antimicrobial activities
Usta, Asu; Yaşar, Ahmet; Yaylı, Nuran; Karaoğlu, Şengül Alpay; Yaylı, Nurettin (TUBİTAK, 2009)A series of 9 new (E) -thiazachalcones (1-3), and their N -alkyl substituted derivatives (4-6), and stereoselective dimerization products (7-9) were synthesized, then tested for antimicrobial activity against all test ... -
Synthesis of novel 2,3-disubstituted quinazolin-4(3H)-one derivatives containing hydrazone skeleton as potent urease inhibitors and their antimicrobial activities
Akyüz, Gülay; Beriş, Fatih Şaban; Kahveci, Bahittin; Menteşe, Emre (Wiley, 2019)A new series of quinazolinones containing hydrazone moiety were synthesized, and their inhibitory activities on urease were assessed in vitro. Most of the compounds exhibited potent urease inhibitory activity. Among the ... -
Synthesis of novel symmetrical 1,4-disubstituted 1,2,3-bistriazole derivatives via 'click chemistry' and their biological evaluation
Düğdü, Esra; Unluer, Dilek; Çelik, Fatih; Sancak, Kemal; Karaoğlu, Şengül Alpay; Özel, Arzu (Mdpi, 2016)A series of symmetric bis-1,2,3-triazole compounds 2-5(a-f) were synthesized as potential antioxidant agents via click chemistry. Their structures were confirmed by H-1-NMR and C-13-NMR. All of the synthesized compounds ...