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Propolis reduces inflammation and dyslipidemia caused by high-cholesterol diet in mice by lowering ADAM10/17 activities

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Erişim

info:eu-repo/semantics/openAccess

Tarih

2024

Yazar

Yiğit, Ertuğrul
Değer, Orhan
Korkmaz, Katip
Yiğit, Merve Hüner
Uydu, Hüseyin Avni
Mercantepe, Tolga
Demir, Selim

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Künye

Yiğit, E., Değer, O., Korkmaz, K., Yiğit, M.H., Uydu, H.A., Mercantepe, T. & Demir, S. (2024). Propolis Reduces Inflammation and Dyslipidemia Caused by High-Cholesterol Diet in Mice by Lowering ADAM10/17 Activities. Nutrients , 16(12), 1861. https://doi.org/10.3390/nu16121861

Özet

Atherosclerosis is one of the most important causes of cardiovascular diseases. A disintegrin and metalloprotease (ADAM)10 and ADAM17 have been identified as important regulators of inflammation in recent years. Our study investigated the effect of inhibiting these enzymes with selective inhibitor and propolis on atherosclerosis. In our study, C57BL/6J mice (n = 16) were used in the control and sham groups. In contrast, ApoE(-/-) mice (n = 48) were used in the case, water extract of propolis (WEP), ethanolic extract of propolis (EEP), GW280264X (GW-synthetic inhibitor), and solvent (DMSO and ethanol) groups. The control group was fed a control diet, and all other groups were fed a high-cholesterol diet for 16 weeks. WEP (400 mg/kg/day), EEP (200 mg/kg/day), and GW (100 mu g/kg/day) were administered intraperitoneally for the last four weeks. Animals were sacrificed, and blood, liver, aortic arch, and aortic root tissues were collected. In serum, total cholesterol (TC), triglycerides (TGs), and glucose (Glu) were measured by enzymatic colorimetric method, while interleukin-1 beta (IL-1 beta), paraoxonase-1 (PON-1), and lipoprotein-associated phospholipase-A2 (Lp-PLA2) were measured by ELISA. Tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), myeloperoxidase (MPO), interleukin-6 (IL-6), interleukin-10 (IL-10), and interleukin-12 (IL-12) levels were measured in aortic arch by ELISA and ADAM10/17 activities were measured fluorometrically. In addition, aortic root and liver tissues were examined histopathologically and immunohistochemically (ADAM10 and sortilin primary antibody). In the WEP, EEP, and GW groups compared to the case group, TC, TG, TNF-alpha, IL-1 beta, IL-6, IL-12, PLA2, MPO, ADAM10/17 activities, plaque burden, lipid accumulation, ADAM10, and sortilin levels decreased, while IL-10 and PON-1 levels increased (p < 0.003). Our study results show that propolis can effectively reduce atherosclerosis-related inflammation and dyslipidemia through ADAM10/17 inhibition.

Kaynak

Nutrients

Cilt

26

Sayı

12

Bağlantı

https://doi.org/10.3390/nu16121861
https://hdl.handle.net/11436/9164

Koleksiyonlar

  • PubMed İndeksli Yayınlar Koleksiyonu [2443]
  • TF, Temel Tıp Bilimleri Bölümü Koleksiyonu [691]
  • WoS İndeksli Yayınlar Koleksiyonu [5260]



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