TF, Dahili Tıp Bilimleri Bölümü Koleksiyonu by Institution Author "Tümkaya, Levent"
Now showing items 41-60 of 68
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Manyetik Rezonans Kontrast Ajanların Sıçan Beyni Üzerine Etkilerinin Histopatolojik Değerlendirilmesi
Çeliker, Fatma Beyazal; Tümkaya, Levent; Mercantepe, Tolga; Beyazal, Mehmet; Turan, Arzu; Burakgazi, Gülen; Hürsoy, Nur (2023)Amaç: Gadolinyum tabanlı kontrast ajanlar (GBCA), manyetik rezonans görüntülemelerde (MRG) kontrast sağlamak amaçlı kullanılmaktadır. GBKA yapısına bağlı olarak beyin dokusu ve diğer dokularda birikim olduğu ile ... -
The nephroprotective effect of amifostine in a cecal ligation-induced sepsis model in terms of oxidative stress and inflammation
Batçık, Şule; Tümkaya, Levent; Mercantepe, Tolga; Atak, Mehtap; Topçu, Atilla; Uydu, Hüseyin Avni; Mercantepe, F. (Verduci Editore, 2022)OBJECTIVE: Sepsis is responsible for more than 5 million deaths worldwide every year. The purpose of this study was to use amifostine to reduce acute kidney injury developing as a result of sepsis. MATERIALS AND METHODS: ... -
A novel model approach for esophageal burns in rats: a comparison of three methods
Kalkan, Yıldıray; Tümkaya, Levent; Akdoğan, Remzi Adnan; Yücel, Ahmet Fikret; Tomak, Yakup; Şehitoğlu, İbrahim; Pergel, Ahmet; Kurt, Aysel (Sage Publications Inc, 2015)Background: Corrosive esophageal injury causes serious clinical problems. We aimed to create a new experimental esophageal burn model using a single catheter without a surgical procedure. Materials and methods: We conducted ... -
Pelvic radiation-induced testicular damage: an experimental study at 1 gray
Rakıcı, Sema Yılmaz; Güzel, Ali İrfan; Tümkaya, Levent; Nalkıran, Hatice Sevim; Mercantepe, Tolga (Taylor & Francis Inc, 2020)Therapeutic radiation of the pelvic region has been shown to cause damage to testicular germ cells. in this study we aimed to evaluate the effects of a low therapeutic dose of 1 Gy on the induction of cellular and histological ... -
The potential antioxidant effect of N-acetylcysteine on X-ray ionizing radiation-induced pancreas islet cell toxicity
Yılmaz, Hamit; Mercantepe, Tolga; Tümkaya, Levent; Merca; Yılmaz, Adnan; Rakıcı, Sema Yılmaz (Elsevier, 2023)Purpose Previous research has highlighted the impact of X-ray irradiation-induced organ damage, on cancer patients after radiation therapy. The ionizing radiation-induced oxidative stress causes injury to the pancreatic ... -
The protective effect of adalimumab on renal injury in a model of abdominal aorta cross-clamping
Cüre, Medine Cumhur; Cüre, Erkan; Kalkan, Yıldıray; Tümkaya, Levent; Aydın, İbrahim; Kırbaş, Aynur; Efe, Hasan; Kurt, Aysel; Yüce, Süleyman (Wroclaw Medical Univ, 2016)Background. Adalimumab (ADA) is a potent inhibitor of tumor necrosis factor (TNF-alpha). ADA treatment suppresses proinflammatory cytokines, leading to a decrease or inhibition of the inflammatory process. Objectives. the ... -
The protective effect of infliximab against carbon tetrachloride-induced acute lung injury
Kurt, Aysel; Tümkaya, Levent; Yüce, Süleyman; Türüt, Hasan; Cüre, Medine Cumhur; Şehitoğlu, İbrahim; Kalkan, Yıldıray; Pusuroğlu, Gökhan; Cüre, Erkan (Mashhad Univ Med Sciences, 2016)Objective(s): Carbon tetrachloride (CCl4) causes pulmonary toxicity. Infliximab (Ib) is a potent inhibitor of tumor necrosis factor-alpha (TNF-alpha). We aimed to investigate whether Ib has a protective effect on CCl4 ... -
Protective effect of infliximab against carbon tetrachloride-induced hepatotoxicity
Şehitoğlu, İbrahim; Tümkaya, Levent; Bedir, Recep; Özer, Ender; Cüre, Medine Cumhur; Yüce, Süleyman; Kalkan, Yıldıray; Cüre, Erkan (Begell House Inc, 2015)Carbon tetrachloride (CCl4), a solvent frequently used in industry, can cause acute liver failure and liver fibrosis. Infliximab (Ib), a potent tumor necrosis factor alpha blocker, has a protective effect on the liver. ... -
Protective effect of infliximab on methotrexate-induced liver injury in rats: Unexpected drug interaction
Cüre, Erkan; Kırbaş, Aynur; Tümkaya, Levent; Cüre, Medine Cumhur; Kalkan, Yıldıray; Yılmaz, Arif; Yüce, Süleyman (Wolters Kluwer Medknow Publications, 2015)Aims: Although methotrexate (mtx) is a widely used agent to treat cancer and inflammatory diseases, its hepatotoxic effect limits for clinical utility. We aimed to investigate whether infliximab (inf), an inhibitor of tumor ... -
Protective effect of whortleberry extract on salivary gland damage induced by neck irradiation in rats
Özgür, Abdulkadir; Terzi, Suat; Özdemir, Doğukan; Tümkaya, Levent; Rakıcı, Sema; Mercantepe, Tolga; Yılmaz, Adnan; Çeliker, Metin; Dursun, Engin (Sage Publications Inc, 2019)Radiotherapy is a method of treatment used on malignant head and neck tumors; however, it may lead to adverse effects by influencing other tissues because its effects are not specific to tumor tissues. These adverse effects ... -
Protective effects of amifostine, curcumin, and melatonin against cisplatin-induced acute kidney injury
Mercantepe, Filiz; Mercantepe, Tolga; Topçu, Atilla; Yılmaz, Adnan; Tümkaya, Levent (Springer, 2018)Despite the enormous advances made in the field of oncology, no solution to the side effect of nephrotoxicity caused by cisplatin used as an antineoplastic agent for approximately 40 years has yet been discovered. This ... -
The protective effects of angiotensin-converting enzyme inhibitor against cecal ligation and puncture-induced sepsis via oxidative stress and inflammation
Kostakoğlu, Uğur; Topçu, Atilla; Atak, Mehtap; Tümkaya, Levent; Mercantepe, Tolga; Uydu, Hüseyin Avni (Pergamon-Elsevier Science Ltd, 2020)Aims: Sepsis is a severe public health problem affecting millions of individuals, with global mortality rates caused by lower respiratory tract infections are approximately 2.38 million people a year die from respiratory ... -
Protective effects of infliximab on lung injury induced by methotrexate
Kurt, Aysel; Tümkaya, Levent; Türüt, Hasan; Cüre, Medine Cumhur; Cüre, Erkan; Kalkan, Yıldıray; Şehitoğlu, İbrahim; Acıpayam, Ahmet (Elsevier Espana Slu, 2015)Introduction: Methotrexate (MTX) is used to treat cancers, several forms of arthritis and other rheumatic conditions, although MIX may cause pulmonary toxicity related to the production of free oxygen radicals, various ... -
Protective effects of nebivolol on ovarian ischemia-reperfusion injury in rat
Çolak, Sabri; Gürlek, Beril; Topçu, Atilla; Tümkaya, Levent; Mercantepe, Tolga; Yılmaz, Adnan (Wiley, 2020)Aim Ovarian torsion is a common gynecological emergency of reproductive ages, occurring at rates of 2.7-7.4%. This study aimed to evaluate the antioxidant effects of Nebivolol (NEB) and histopathological changes in ... -
The protective effects of perindopril against acute kidney damage caused by septic shock
Kostakoğlu, Uğur; Mercantepe, Tolga; Yılmaz, Hülya Kılıç; Tümkaya, Levent; Batçık, Şule; Pınarbaş, Esra; Uydu, Hüseyin Avni (Springer/Plenum Publishers, 2021)Acute kidney injury (AKI) resulting from septic shock caused by sepsis is an important health problem encountered at rates of 55-73%. Increasing oxidative stress and inflammation following sepsis is a widely observed ... -
The protective effects of red ginseng and amifostine against renal damage caused by ionizing radiation
Yılmaz, Hamit; Karakoç, Yunus; Tümkaya, Levent; Mercantepe, Tolga; Sevinç, Hacer; Yılmaz, Adnan; Rakıcı, Sema Yılmaz (2022)This study aimed to elucidate the effects of amifostine (ethyol) (AM), a synthetic radioprotector, and red ginseng (RG), a natural radioprotective agent, against the toxic effect of ionizing radiation (IR) on kidney tissues ... -
Protective effects of tumor necrosis factor alpha inhibitors on methotrexate-induced pancreatic toxicity
Mercantepe, Tolga; Kalkan, Yıldıray; Tümkaya, Levent; Şehitoğlu, İbrahim; Mercantepe, Filiz; Yıldırmış, Sermet (Wroclaw Medical Univ, 2018)Background. Methotrexate (MTX), a folate antagonist, is commonly used in the treatment of many different types of cancer and inflammatory diseases, including pancreatic cancer, although its side effects on the pancreas ... -
The protective role of fosfomycin in lung injury due to oxidative stress and inflammation caused by sepsis
Yıldız, İlknur Esen; Topçu, Atilla; Bahçeci, İlkay; Arpa, Medeni; Tümkaya, Levent; Mercantepe, Tolga; Batçık, Şule; Yıldız, Yasin (Pergamon-Elsevier Science Ltd., 2021)Aim: Early and prompt treatment of sepsis by effective antibiotics against susceptible organisms may be lifesaving. However, increased antibiotic resistance and side effects of chemotherapeutic agents limiting their ... -
Radioprotective effect of endogenous melatonin secretion associated with the circadian rhythm in irradiated rats
Rakıcı, Sema Yılmaz; Tümkaya, Levent; Erdivanlı, Özlem Çelebi; Yazıcı, Ufuk; Dursun, Engin; Arpa, Medeni; Mercantepe, Tolga (Taylor & Francis Ltd, 2019)Purpose: We investigated the radioprotective effect of endogenous melatonin release at different times associated with the circadian rhythm on head and neck radiotherapy. Materials and methods: Two groups of animals were ...