Yazar "Tümkaya, Levent" için TF, Temel Tıp Bilimleri Bölümü Koleksiyonu listeleme
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Topiramate has protective effect on renal injury
Cüre, Medine Cumhur; Cüre, Erkan; Tümkaya, Levent; Kalkan, Yıldıray; Aydın, İlkyaz; Kırbaş, Aynur; Efe, Hasan; Şehitoğlu, İbrahim; Yüce, Süleyman (Comenius Univ, 2015)Background: Topiramate (TPM) decreases tumor necrosis factor-alpha (TNF-alpha) and oxidative stress. We investigated protective effects of TPM on cell damage in kidney tissue during ischemia-reperfusion (I/R) damage. ... -
Topiramate reduces aortic cross-clamping-induced lung injury in male rats
Kurt, Aysel; Kalkan, Yıldıray; Türüt, Hasan; Cüre, Medine Cumhur; Tümkaya, Levent; Cüre, Erkan (NLM (Medline), 2018)BACKGROUND: Topiramate (TPM) decreases cytokine release and generation of reactive oxygen species (ROS). Cytokine and endothelin-1 (ET-1) secretion and ROS formation play an important role in ischemia-reperfusion (I/R) ... -
Toward changing of the pathophysiologic Basis of Acute Hydrocephalus after subarachnoid hemorrhage: a preliminary experimental study
Kanat, Ayhan; Türkmenoğlu, Osman; Aydın, Mehmet D.; Yolşs, Coşkun; Aydın, Nazan; Gürsan, Nesrin; Tümkaya, Levent; Demir, Recep (Elsevier Science Inc, 2013)BACKGROUND: Acute hydrocephalus (ventricular enlargement within 72 hours) is a common complication in patients with aneurysmal subarachnoid hemorrhage (SAH). Cerebrospinal fluid (CSF) secretion may be increased in the early ... -
White tea reduced bone loss by suppressing the TRAP/CTX pathway in ovariectomy-induced osteoporosis model rats
Yıldırım, Murat; Saral, Sinan; Mercantepe, Tolga; İskender, Hatice; Tümkaya, Levent; Atak, Mehtap; Taşçı, Filiz (S. Karger AG, 2020)Osteoporosis is an important skeletal disease characterized by bone weakness and high risk of fracture in postmenopausal women. Tea consumption is known to play an important role in the prevention or alleviation of ... -
Whortleberry protects kidney against the cisplatin-induced nephrotoxicity: an experimental study
Eren, Hüseyin; Aydın, Hasan Rıza; Tümkaya, Levent; Kazaz, İlke Onur; Kalkan, Yıldıray; Kazaz, Seher Nazlı; Mercantepe, Tolga; Horsanali, Mustafa Ozan; Yılmaz, Adnan (Taylor & Francis Ltd, 2018)Purpose: This study investigated the antioxidant effects of whortleberry against cisplatin-induced nephrotoxicity in rats.Material and methods: This study included 48 female Sprague-Dawley rats weighing 263.688.29g. the ... -
Yetişkin sıçanlarda testis hücreleri ve kalsinörin ımmunopozitifliği üzerine ketaminin etkileri: Bir ımmunohistokimyasal ve histopatolojik çalışma
Kalkan, Yıldıray; Tümkaya, Levent; Bostan, Habib; Tomak, Yakup; Altuner, Durdu; Baş, Orhan; Zorba, Orhan Ünal; Uzun, Hakkı (2012)Bu çalışmada, sıçanlara uygulanan uzun süreli ketaminin testis germ hücreleri ve kalsinörin immunopozitif hücreler üzerine etkilerinin araştırılması amaçlandı. Otuz adet, yetişkin Sprague-Dawley erkek sıçan her grupta 6’şar ... -
Zoledronic acid aggravates kidney damage during ischemia reperfusion injury in rat
Şehitoğlu, İbrahim; Tümkaya, Levent; Bedir, Recep; Kalkan, Yıldıray; Cüre, Medine Cumhur; Yücel, Ahmet Fikret; Zorba, Orhan Ünal; Yüce, Süleyman; Cüre, Erkan (Begell House Inc., 2015)Introduction: Zoledronic acid (ZA), a bisphosphonate, increases the levels of cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-?), and reactive oxygen species (ROS) in subjects without cancer. ...