Yazar "Cüre, Medine Cumhur" için TF, Temel Tıp Bilimleri Bölümü Koleksiyonu listeleme
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Protective effect of infliximab on methotrexate-induced liver injury in rats: Unexpected drug interaction
Cüre, Erkan; Kırbaş, Aynur; Tümkaya, Levent; Cüre, Medine Cumhur; Kalkan, Yıldıray; Yılmaz, Arif; Yüce, Süleyman (Wolters Kluwer Medknow Publications, 2015)Aims: Although methotrexate (mtx) is a widely used agent to treat cancer and inflammatory diseases, its hepatotoxic effect limits for clinical utility. We aimed to investigate whether infliximab (inf), an inhibitor of tumor ... -
Protective effects of infliximab on lung injury induced by methotrexate
Kurt, Aysel; Tümkaya, Levent; Türüt, Hasan; Cüre, Medine Cumhur; Cüre, Erkan; Kalkan, Yıldıray; Şehitoğlu, İbrahim; Acıpayam, Ahmet (Elsevier Espana Slu, 2015)Introduction: Methotrexate (MTX) is used to treat cancers, several forms of arthritis and other rheumatic conditions, although MIX may cause pulmonary toxicity related to the production of free oxygen radicals, various ... -
Protective effects of thymoquinone and alpha-tocopherol on the sciatic nerve and femoral muscle due to lower limb ischemia-reperfusion injury
Erkut, Adem; Cüre, Medine Cumhur; Kalkan, Yıldıray; Balık, Mehmet Sabri; Güvercin, Yılmaz; Yaprak, Esra; Yüce, Süleyman; Şehitoğlu, İbrahim; Cüre, Erkan (Verduci Publisher, 2016)OBJECTIVE: Thymoquinone (TQ) is an antioxidant and anti-apoptotic substance found in the Nigella sativa plant. Alpha-tocopherol (alpha-TP) is a potent antioxidant. We aimed to determine whether or not TQ and TP have a ... -
The relationship between atherogenic index and carotid artery atherosclerosis in familial mediterranean fever: A pilot study
İçli, Abdullah; Cüre, Erkan; Uslu, Ali Uğur; Sakız, Davut; Cüre, Medine Cumhur; Özuçan, Miyase; Baykara, Rabia Aydoğan; Karakoyun, Ahmet; Balta, Şevket; Öztürk, Cengiz; Arslan, Şevket; Küçük, Adem (Sage Publications Inc, 2017)Familial Mediterranean fever (FMF) is a disease characterized by chronic inflammation. Atherogenic index of plasma (AIP) is a logarithmic value of the triglyceride to high-density lipoprotein cholesterol ratio and it is a ... -
Relationship between site of myocardial infarction, left ventricular function and cytokine levels in patients undergoing coronary artery surgery
Kiriş, İlker; Kapan, Şahin; Narin, Cüneyt; Özaydın, Mehmet; Cüre, Medine Cumhur; Sütçü, Recep; Okutan, Hüseyin (Clinics Cardive Publ Pty Ltd, 2016)Background: the purpose of this study was to examine the relationship between left ventricular (LV) function, cytokine levels and site of myocardial infarction (MI) in patients undergoing coronary artery bypass grafting ... -
Relationship of osteoprotegerin to pulse wave velocity and carotid intima-media thickness in rheumatoid arthritis patients
Beyazal, Münevver Serdaroğlu; Erdoğan, Turan; Devrimsel, Gül; Türkyılmaz, Ayşegül Küçükali; Cüre, Medine Cumhur; Beyazal, Mehmet; Şahin, İsmail (Springer Heidelberg, 2016)Osteoprotegerin (OPG) is considered an important biomarker in cardiovascular (CV) disease. CV disease is the most common cause of mortality in patients with rheumatoid arthritis (RA), a consequence of accelerated ... -
Relationship of serum osteoprotegerin with arterial stiffness, preclinical atherosclerosis, and disease activity in patients with ankylosing spondylitis
Beyazal, Münevver Serdaroğlu; Erdoğan, Turan; Türkyılmaz, Ayşegül Küçükali; Devrimsel, Gül; Cüre, Medine Cumhur; Beyazal, Mehmet; Şahin, İsmail (Springer London Ltd, 2016)Patients with ankylosing spondylitis (AS) reportedly have a higher mortality and morbidity risk. Osteoprotegerin (OPG) was recently defined as an important cardiovascular (CV) marker in the general population. We aimed to ... -
Relationships between C-kit expression and mean platelet volume in benign, preneoplastic and neoplastic endometrium
Şehitoğlu, İbrahim; Bedir, Recep; Ural, Ülkü Mete; Güçer, Hasan; Yurdakul, Cüneyt; Cüre, Medine Cumhur; Cüre, Erkan; Yüce, Süleyman; Şahin, Figen Kır (Asian Pacific Organization for Cancer Prevention, 2015)Background: c-Kit is a proto-oncogene that encodes a tyrosine kinase receptor (CD117). Mean platelet volume (MPV) is a useful marker for demonstrating thrombocyte function. We aimed to investigate whether c-kit is expressed ... -
Serum fibronectin levels in acute and chronic viral hepatitis patients
Ertürk, Ayşe; Cüre, Erkan; Özkurt, Zülal; Parlak, Emine; Cüre, Medine Cumhur (Malaysian Journal of Medical Sciences, 2014)Background: The aim of this study was to investigate the serum fibronectin (FN) levels and liver enzyme activities in patients with acute hepatitis (A, B, C) and chronic viral hepatitis (B, C); determine whether the virus ... -
Serum levels of homocysteine, asymmetric dimethylarginine and nitric oxide in patients with Parkinson's disease
Kırbaş, Serkan; Kırbaş, Aynur; Tufekçi, Ahmet; Cüre, Medine Cumhur; Çakmak, Sevim; Yazıcı, Tarkan; Cüre, Erkan (Taylor & Francis Ltd, 2016)Objectives: Endothelial dysfunction has been implicated as a crucial event in the development of several neurodegenerative diseases. the aim of this study was to investigate the serum homocysteine, asymmetric dimethylarginine ... -
Serum levels of IL-17, IL-6, TNF-alpha and disease activity in patients with rheumatoid arthritis
Beyazal, Münevver Serdaroğlu; Devrimsel, Gül; Cüre, Medine Cumhur; Türkyılmaz, Ayeşegül Küçükali; Çapkın, Erhan; Karkucak, Murat (Georg Thieme Verlag Kg, 2017)Objective the aim of this study was to evaluate serum levels of interleukin (IL)-17, IL-6, and tumor necrosis factor alpha (TNF-alpha) in RA patients and to assess the correlation of these cytokines with clinical and ... -
Serum macrophage migration inhibitory factor levels in Hashimoto's thyroiditis; a case control study
Ayaz, Teslime; Şahin, Serap Baydur; Şahin, Osman Zikrullah; Cüre, Medine Cumhur; Sümer, Fatih; İlkkılıç, Kadir (BioMed Central Ltd., 2014)Objective: The cell-mediated immune process by CD4+ and CD8+ lymphocyte subsets of T-cells has a major role in the pathogenesis of Hashimoto's thyroiditis (HT). However, the exact mechanisms of initiation and progression ... -
Serum resistin levels may be new prognostic factor of crimean-congo hemorrhagic fever
Ertürk, Ayşe; Cüre, Erkan; Parlak, Emine; Cüre, Medine Cumhur; Yüce, Süleyman; Kızılkaya, Bayram (E-Century Publishing Corp, 2014)Crimean-Congo hemorrhagic fever (CCHF) virus can cause potentially fatal infections in humans. During this disease, cytokines are intensive released. Resistin which is a good marker of inflammation is an adipocytokine ... -
Serum YKL-40 levels as a novel marker of inflammation in patients with endometriosis
Ural, Ülkü Mete; Tekin, Yeşim Bayoğlu; Cüre, Medine Cumhur; Şahin, Figen Kır (Imr Press, 2015)Purpose: To establish serum YKL-40 concentrations in patients with endometriosis compared to age-matched healthy subjects. Materials and Methods: This was a cross-sectional clinical study conducted in a tertiary care center. ... -
Topiramate ameliorates abdominal aorta cross-clamping induced liver injury in rats
Cüre, Erkan; Cüre, Medine Cumhur; Tümkaya, Levent; Kalkan, Yıldıray; Aydın, İbrahim; Kırbaş, Aynur; Yılmaz, Arif; Yüce, Süleyman; Gökçe, Mehmet Fatih (Wolters Kluwer Medknow Publications, 2014)Background and Aim: Ischemia/reperfusion (I/R) injury in the liver occurs after a prolonged period of ischemia followed by restoration of hepatic blood perfusion. During the surgery of abdominal aorta, I/R injury causes ... -
Topiramate has protective effect on renal injury
Cüre, Medine Cumhur; Cüre, Erkan; Tümkaya, Levent; Kalkan, Yıldıray; Aydın, İlkyaz; Kırbaş, Aynur; Efe, Hasan; Şehitoğlu, İbrahim; Yüce, Süleyman (Comenius Univ, 2015)Background: Topiramate (TPM) decreases tumor necrosis factor-alpha (TNF-alpha) and oxidative stress. We investigated protective effects of TPM on cell damage in kidney tissue during ischemia-reperfusion (I/R) damage. ... -
Topiramate reduces aortic cross-clamping-induced lung injury in male rats
Kurt, Aysel; Kalkan, Yıldıray; Türüt, Hasan; Cüre, Medine Cumhur; Tümkaya, Levent; Cüre, Erkan (NLM (Medline), 2018)BACKGROUND: Topiramate (TPM) decreases cytokine release and generation of reactive oxygen species (ROS). Cytokine and endothelin-1 (ET-1) secretion and ROS formation play an important role in ischemia-reperfusion (I/R) ... -
Zoledronic acid aggravates kidney damage during ischemia reperfusion injury in rat
Şehitoğlu, İbrahim; Tümkaya, Levent; Bedir, Recep; Kalkan, Yıldıray; Cüre, Medine Cumhur; Yücel, Ahmet Fikret; Zorba, Orhan Ünal; Yüce, Süleyman; Cüre, Erkan (Begell House Inc., 2015)Introduction: Zoledronic acid (ZA), a bisphosphonate, increases the levels of cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-?), and reactive oxygen species (ROS) in subjects without cancer. ...