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Investigation of the cyp3a4 and pon1 gene variants in turkish patients with familial coronary artery disease
(Lippincott Williams & Wilkins, 2015)
Objective:
Coronary artery disease (CAD), a complex multifactorial disorder, has been suggested to be associated by the interaction of both environmental and genetic risk factors.
The CYP 2C19*2 and CYP2C19*17 polymorphisms play a vital role in platelet responsiveness to clopidogrel after percutaneous coronary intervention: a pharmacogenomic study
(Elsevier, 2015)
Background: Clopidogrel inhibits platelet activation and aggregation by blocking the P2Y12 receptor. Dual antiplatelet therapy with
clopidogrel and aspirin is recommended treatment by current guidelines for patients ...