Güncel Gönderiler: TF, Temel Tıp Bilimleri Bölümü Koleksiyonu
Toplam kayıt 717, listelenen: 1-20
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Enhancing hepatocellular carcinoma surveillance: comparative evaluation of AFP, AFP-L3, DCP and composite models in a biobank-based case-control study
(MDPI (Multidisciplinary Digital Publishing Institute), 2025)Background/Objectives: Biomarkers such as lens agglutinin-reactive alpha-fetoprotein and des-gamma-carboxy prothrombin, as well as biomarker- and/or clinical-parameter-derived composite models (GALAD, GAAP, ASAP, aMAP, ... -
GDF-15 levels in gouty arthritis and correlations with decreasing renal function: a clinical study
(MDPI (Multidisciplinary Digital Publishing Institute), 2025)Background/Objectives: Gouty arthritis (GA) is a chronic inflammatory disorder frequently linked to systemic inflammation and impaired kidney function. Growth differentiation factor-15 (GDF-15) has been suggested as a ... -
Immature platelet fraction as a sensitive biomarker in neonatal sepsis: diagnostic performance preceding thrombocytopenia
(MDPI (Multidisciplinary Digital Publishing Institute), 2025)Background: Early and accurate diagnosis of neonatal sepsis remains a clinical challenge due to nonspecific signs and limitations of conventional biomarkers. The immature platelet fraction (IPF), a novel hematologic parameter ... -
A case-control study on the role of carbonic anhydrase autoantibodies in the pathogenesis and diagnosis of fibromyalgia
(Nature Research, 2025)To investigate the levels and diagnostic significance of carbonic anhydrase I (CAI) and II (CAII) autoantibodies and oxidative stress status in fibromyalgia syndrome (FMS) patients. A total of 59 FMS patients and 53 healthy ... -
Design, synthesis, and evaluation of benzimidazole-carbazole hybrids targeting heat shock proteins-mediated apoptosis in breast and colon cancer cells
(Wiley, 2025)Heat shock proteins (HSPs), particularly HSP70 and HSP90, are pivotal molecular chaperones implicated in cancer progression and resistance mechanisms. Dual inhibition of these chaperones represents a promising therapeutic ... -
Serum Npas-4 and nptx-2 levels in alzheimer’s disease: potential biomarkers of synaptic dysfunction in a cross-sectional study
(MDPI, 2025)Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, synaptic dysfunction, and neuronal loss. Identifying reliable biomarkers for early diagnosis and disease ... -
Protective effects of dexmedetomidine and amifostine against radiotherapy-induced kidney injury
(MDPI, 2025)Backgrounds: Approximately 18 million individuals were diagnosed with cancer in 2018. The rate is predicted to exceed 22 million by 2030. Radiotherapy is an essential part of cancer therapy, with well documented local and ... -
The experience of the Turkish Red Crescent blood banks in the 2023 Türkiye earthquake
(Wiley, 2025)AimThis cross-sectional study aimed to determine the impact of a severe earthquake on blood donation as per blood safety and donation behaviour.Materials and MethodsThis retrospective cross-sectional study included a total ... -
Exploring the bioremediation potential of nonpathogenic Pb-resistant strain Klebsiella pneumoniae in Oreochromis niloticus
(Taylor and Francis Ltd., 2025)Lead (Pb) has been released into the environment due to increased urbanization in recent years, causing severe environmental impacts on soil and water. Therefore, the goal of the present study is to investigate the ... -
In vitro effects of rumex confertus extracts on cell viability and molecular pathways in MCF-7 breast cancer cells
(MDPI, 2025)Rumex confertus (RC), a plant known for its traditional medicinal uses, has shown potential anticancer properties, particularly due to its rich phenolic content. Despite its promising bioactivity, its effects on breast ... -
HSP inhibitor sensitize resistant MCF-7 cells to doxorubicin through suppressing HSP90AB4P pseudogene and HSPB1 expression
(Bentham Science Publishers, 2025)Introduction: Doxorubicin, a first-line chemotherapeutic agent, often faces resistance in breast cancer subtypes, leading to treatment failure. HSPs (Heat shock proteins), especially HSP90, and their pseudogenes like ... -
Hi-labspermtracking: a novel and high-quality sperm tracking dataset with an advanced ensemble detection and tracking approach for real-world clinical scenarios
(John Wiley and Sons Inc, 2025)Sperm motility, a critical factor in diagnosing male infertility, requires computer-based solutions due to the limitations of manual evaluation methods. This study introduces the Hi-LabSpermTracking dataset, comprising 66 ... -
Silodosin-induced anejaculation: a promising agent for male oral contraception
(MRE Press, 2025)Background: The objective of this study was to investigate the feasibility of utilizing silodosin as a non-hormonal, reversible, oral contraceptive for men, alongside elucidating its mechanism of action pertaining to ... -
Phytochemical profiling and anticancer potential of pistachio wastes against MCF-7 breast cancer cells: a metabolic and apoptotic pathway analysis
(BioMed Central Ltd, 2025)Food waste poses significant environmental, economic, and social challenges worldwide. Pistachio waste is recognized for its health benefits, particularly for its anticancer properties. This study assessed the phytochemical ... -
Analysis of MMP-8, MMP-20, and TGF-β1 in molar-incisor hypomineralization and assessment of periodontal health
(BMC, 2025)Background: Gingival crevicular fluid (GCF) volume can be used to evaluate periodontal diseases, along with matrix metalloproteinase-8 (MMP-8) and transforming growth factor-beta 1 (TGF-β1) found in GCF. Conversely, matrix ... -
Somatostatin and N-acetylcysteine on testicular damage triggered by ischemia reperfusion: cellular protection and antioxidant effects
(Springer Nature, 2025)Ischemia–reperfusion (I/R) injury is a significant cause of testicular damage, leading to infertility and other reproductive dysfunctions. Antioxidant therapies have emerged as a potential intervention to mitigate oxidative ... -
Can iron absorption in molasses be increased with probiotic additives? “molasses with increased bioavailability”
(MDPI, 2025)Introduction: There are many studies on the chemical and enzymatic interactions of probiotics, and the effects of Lactobacillus plantarum 299v on iron absorption have been clearly shown. The aim of this study was to ... -
Effects of intermittent fasting on liver steatosis and fibrosis, serum FGF-21 and autophagy markers in metabolic dysfunction-associated fatty liver disease: a randomized controlled trial
(MDPI, 2025)Background: This randomized controlled study sought to determine the effect of intermittent fasting on anthropometric measurements, fibroblast growth factor (FGF)-21, and autophagy markers, as well as on hepatic steatosis ... -
Association of inflammatory and ischemic markers with posterior segment parameters in pseudoexfoliation syndrome and glaucoma
(MDPI, 2025)Objective: This study aimed to investigate the structural, vascular, and biochemical alterations in patients with pseudoexfoliation syndrome (PES) and pseudoexfoliative glaucoma (PXG) and to evaluate the associations between ... -
The role of AMY1 gene copy number variation in dental caries susceptibility: insights from a Turkish population
(Springer Nature, 2025)Objective: Dental caries is a multifactorial disease influenced by environmental, behavioral, and genetic factors. Recent studies suggest that variations in the AMY1 gene, which encodes salivary amylase, may contribute to ...
