dc.contributor.author | Yılmaz, Fatih | |
dc.contributor.author | Menteşe, Emre | |
dc.contributor.author | Sökmen, Bahar Bilgin | |
dc.date.accessioned | 2020-12-19T19:32:16Z | |
dc.date.available | 2020-12-19T19:32:16Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Yilmaz, F., Mentese, E., Sokmen, B.B. (2020). Synthesis and biological evaluation of some 1,3-benzoxazol-2(3H)-one hybrid molecules as potential antioxidant and urease inhibitors. Journal of Heterocyclic Chemistry, 58(1), 260-269. https://doi.org/10.1002/jhet.4165 | en_US |
dc.identifier.issn | 0022-152X | |
dc.identifier.issn | 1943-5193 | |
dc.identifier.uri | https://doi.org/10.1002/jhet.4165 | |
dc.identifier.uri | https://hdl.handle.net/11436/975 | |
dc.description | WOS: 000578997200001 | en_US |
dc.description.abstract | A new series of 1,3-benzoxazol-2(3H)-one hybrid compounds, including coumarin, isatin 1,3,4-triazole and 1,3,4-thiadiazole moieties, were synthesized and biologically evaluated for their antioxidant capacities and anti-urease properties. the synthesized benzoxazole-coumarin (6a-e) and benzoxazole-isatin (10a-c) hybrids showed remarkable urease inhibitory activities with IC50(mu M), ranging from 0.0306 +/- 0.0030 to 0.0402 +/- 0.0030, while IC(50)of standard thiourea is 0.5027 +/- 0.0293. the synthesized benzoxazole-triazole (8a-c) and benzoxazole-thiadiazole (9a-c) hybrids showed similar urease inhibitory activities with IC50(mu M), ranging from 0.3861 +/- 0.0379 to 0.5126 +/- 0.0345. the antioxidant activity of the synthesized compounds was evaluated for their antioxidant activities, such as reducing power and ABTS (2,2 '-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt) radical scavenging. the results of ABTS radical scavenging activities of some of the synthesized molecules showed higher activities than standard Trolox, SC50(mu M) = 213.04 +/- 18.12. One benzoxazole-coumarin (6f), two benzoxazole-isothiocyanate (7b, 7c), and two benzoxazole-triazole (8b, 8c) derivatives showed higher activities (SC50(mu M) values, 82.07 +/- 10.34, 120.19 +/- 7.30, 104.58 +/- 10.55, 153.26 +/- 7.14, and 144.82 +/- 10.68, respectively) than standard Trolox, (SC50(mu M) = 213.04 +/- 18.12). | en_US |
dc.description.sponsorship | Recep Tayyip Erdogan UniversitesiRecep Tayyip Erdogan University [FBA-2018-858] | en_US |
dc.description.sponsorship | Recep Tayyip Erdogan Universitesi, Grant/Award Number: FBA-2018-858 | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | In vitro | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Derivatives | en_US |
dc.subject | Docking | en_US |
dc.subject | Desing | en_US |
dc.subject | Antibacterial | en_US |
dc.subject | Benzoxazole | en_US |
dc.subject | Involvement | en_US |
dc.title | Synthesis and biological evaluation of some 1,3-benzoxazol-2(3H)-one hybrid molecules as potential antioxidant and urease inhibitors | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.contributor.institutionauthor | Yılmaz, Fatih | |
dc.contributor.institutionauthor | Menteşe, Emre | |
dc.identifier.doi | 10.1002/jhet.4165 | |
dc.relation.journal | Journal of Heterocyclic Chemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |