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dc.contributor.authorSuzan, Zehra Topal
dc.contributor.authorTümkaya, Levent
dc.contributor.authorMercantepe, Tolga
dc.contributor.authorAtak, Muhammed
dc.contributor.authorUydu, Hüseyin Avni
dc.date.accessioned2020-12-19T19:32:21Z
dc.date.available2020-12-19T19:32:21Z
dc.date.issued2021
dc.identifier.citationSuzan, Z. T., Tumkaya, L., Mercantepe, T., Atak, M., & Uydu, H. (2021). The effect of imatinib administered in the prenatal period on testis development in rats. Human & Experimental Toxicology, 634–648. https://doi.org/10.1177/0960327120958458en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.urihttps://doi.org/10.1177/0960327120958458
dc.identifier.urihttps://hdl.handle.net/11436/999
dc.descriptionWOS: 000575471100001en_US
dc.descriptionPubMed: 32990058en_US
dc.description.abstractBackground: the purpose of this study was to examine the effects of exposure to imatinib in the prenatal period on testis development in rats. Methods: Although all the study groups received intraperitoneal imatinib on prenatal days 1-8, no pregnancy occurred in the Imatinib-80 group. Immunohistochemical analysis, TUNEL, c-kit and PDGF staining revealed no difference between the groups in terms of positivity scoring. Results: A significant decrease was detected in total sperm counts in the Imatinib-20 group compared to the control group, but the sperm count was higher in the Imatinib-60 group than in the Imatinib-20 group. At biochemical measurements, the drug increased oxidative stress in the testis and serum in the Imatinib-20 group, but caused a decrease in tissue in the Imatinib-60 group. Thiol measurements revealed a decrease in the testis and serum in the Imatinib-60 group, while an increase in serum measurements was observed in the Imatinib-40 group. Analysis revealed no difference between the groups in terms of protamine and histone gene expression levels in testis tissue exposed to imatinib. Conclusion: Our findings show that prenatal exposure to imatinib can lead to histopathological and biochemical changes in testis tissue, but that no adverse effect occurs in nuclear maturation of germ cells during spermiogenesis.en_US
dc.description.sponsorshipRecep Tayyip Erdogan University, Rize, TurkeyRecep Tayyip Erdogan University [TDK-2017-825]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Recep Tayyip Erdogan University, Rize, Turkey [TDK-2017-825].en_US
dc.language.isoengen_US
dc.publisherSage Publications Ltden_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectC-kiten_US
dc.subjectiImatiniben_US
dc.subjectPDGFen_US
dc.subjectTestisen_US
dc.subjectTUNELen_US
dc.subjectRaten_US
dc.titleThe effect of imatinib administered in the prenatal period on testis development in ratsen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorSuzan, Zehra Topal
dc.contributor.institutionauthorTümkaya, Levent
dc.contributor.institutionauthorMercantepe, Tolga
dc.contributor.institutionauthorAtak, Muhammed
dc.contributor.institutionauthorUydu, Hüseyin Avni
dc.identifier.doi10.1177/0960327120958458
dc.relation.journalHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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