Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Exploring noninfectious radiological lung findings in adult patients with primary immunodeficiency diseases
(Exon Publications, 2025) Aykan, Filiz Sadi; Çölkesen, Fatih; Evcen, Recep; Kılınç, Mehmet; Yıldız, Eray; Ergün, Ümmügülsüm Yılmaz; Arslan, Şevket
Primary immunodeficiency diseases (PIDs) show different patterns of airway involvement, particularly bronchiectasis; however, comparative studies of radiologic manifestations in patients with PIDs are scarce. Hence, the aim of this study to investigate radiologic lung findings in adult patients with PIDs and evaluate the possible relationship between clinical and immunologic features and respiratory function in these patients. In this study, the demographic and clinical characteristics, serum immunoglobulins (Ig), lymphocyte subgroups, high-resolution computed tomography (HRCT), and pulmonary function tests (PFTs) of 116 adult patients with PID were evaluated and those with and without abnormal HRCT were compared. The median age was 40 (28–48) years, and there were 51 (44%) females. Abnormal findings were detected in 55.2% of the HRCTs, but the most common findings were bronchiectasis (30.2%), bilateral involvement (73.5%), and lower lobe predominance. The median age and age of diagnosis were higher in those with HRCT findings. The obstructive pattern was the most common found in the PFTs. Forced vital capacity, maximal mid-expiratory flow at 25–75%, immunoglobulin G (IgG), immunoglobulin A (IgA), immunoglobulin M (IgM), cluster of differentiation (CD)4+ T cell, CD4+/CD8+ ratio, and class-switched memory B (cSMB) cell levels were significantly lower, whereas mortality was higher. Noninfectious pulmonary complications are among the important causes of morbidity and mortality in PID that could result in chronic lung disease despite adequate Ig therapy. Considering the extra radiation dose of HRCT, clinical findings and immunological and PFT parameters accompanying radiological features may be helpful in predicting the diagnosis; it may also be useful in determining additional treatment modalities and reducing mortality.
An example of clonal micropropagation of endemic bulbous ornamental plants: bellevalia tauri
(Academic Publishing House, 2025) Nasırcılar, Ayşe Gül; Karagüzel, Özgül; Mirici, Semra; Eren, Özkan
Bellevalia tauri Feinbrun which has great potential as an ornamental, is an endemic bulbous plant of the Asparagaceae family. This study, one of a very limited number of in vitro culture studies in Bellevalia species, investigated the in vitro clonal propagation potential of immature zygotic embryos and twin bulb scale explants of B. tauri. Surface sterilization of immature embryos was performed using commercial bleach and ethanol. In addition to these, hot water applications were also tested in bulb scale explants to overcome the heavy contamination. Both explant types were cultured in MS medium containing different ratios of BAP and NAA after sterilization. Although there was no contamination after sterilization in immature embryos, it was quite difficult to overcome contamination in bulb scale explants despite different sterilization methods. The in vitro regeneration method also differed according to the type of explant used in the study. New bulb formation was achieved by direct organogenesis from bulb scale explants and by indirect organogenesis after callus formation from cultured immature embryos. The highest callus and bulblet formation from immature embryo explant was obtained on medium supplemented with 2.0 mg L−1 BAP + 0.25 mg L−1 NAA medium. In this medium, percentage of explants forming callus and number of bulblets per explant were determined as 100% and 3.43, respectively. As a result of the chromosome analysis performed to determine whether plant growth regulators have an effect on the chromosome number and morphology of B. tauri in tissue culture, no anomalies were detected in the chromosome number and structure.
Cardiometabolic risk in non-diabetic metabolic dysfunction-associated steatotic liver disease (MAFLD) patients: insights from the triglyceride-glucose, plasma atherogenic, and cardiometabolic index
(Termedia Publishing House Ltd., 2025) Çiftel, Sedat; Çiftel, Serpil; Baykan, Ahmed R.; Cerrah, Serkan; Çiftel, Enver; Mercantepe, Filiz
Introduction: The objective of our study was to examine the correlation between hepatosteatosis and the triglyceride-glucose index (TyG), plasma atherogenic index (PAI), and cardiometabolic index (CMI) in nondiabetic patients. We also aimed to assess the usefulness of these indices in evaluating cardiometabolic risk in metabolic dysfunction-associated steatotic liver disease (MAFLD). Material and methods: This retrospective cross-sectional study included 695 individuals who did not have diabetes, with an average age of 39.8 ±11.3 years. A total of 595 individuals, comprising 359 women and 236 men, were diagnosed with MAFLD. The control group consisted of 100 individuals who did not have MAFLD. All the subjects underwent transabdominal ultrasonography, anthropometric measurements, and blood analyses. The groups were assessed based on the TyG index, PAI, and CMI. Results: TyG, PAI, and CMI were greater in patients with MAFLD than those without MAFLD. The TyG index, with a cutoff point of 8.47, excluded significant simple steatosis with a sensitivity of 65.3% and a specificity of 66.0%. The PAI and CMI cutoff values were 0.39 and 1.40, with sensitivities of 66.6% and 70.1% and specificities of 67.0% and 70.1%, respectively. The TyG index was independently associated with MAFLD (OR = 2.21, 95% CI: 1.339–3.665). Conclusions: The presence of MAFLD patients with a normal BMI and waist circumference indicates that these variables alone do not provide enough evidence for the diagnosis of MAFLD. Hence, it is advisable to incorporate the TyG index, the PAI, and the CMI into regular clinical practice to obtain a more precise and thorough evaluation of MAFLD and cardiometabolic risk.
Consimilarity of hybrid number matrices and hybrid number matrix equations A˜X − XB = C
(American Institute of Mathematical Sciences, 2025) Çakır, Hasan
This research aims to investigate the consimilarity of hybrid number matrices and to develop solutions for matrix equations associated with these numbers. Hybrid numbers are an innovative algebraic structure that unifies dual, complex, and hyperbolic (perplex) number systems. These numbers are isomorphic to split quaternions and hold significant importance in mathematical theory and physical applications, especially in the context of non-commutative algebraic structures. The paper demonstrates how linear matrix equations associated with hybrid numbers, such as A˜X − XB = C, can be solved by reducing them to Sylvester equations through real matrix representations. The concept of consimilarity, defined as a transformation preserving structural properties of matrices without requiring invertibility, is thoroughly examined. This concept is applied to analyze eigenvalues, diagonalization, and both linear and nonlinear matrix equations involving hybrid number matrices. By investigating the consimilarity of hybrid number matrices, the study introduces new algebraic methods and computational techniques, expanding classical results in matrix theory to hybrid numbers. This research not only advances theoretical insights into hybrid number systems but also opens avenues for practical applications in scientific and engineering fields.
Research on turkish and u.S. Teachers as mandated reporters of child abuse and neglect: a comparative scoping review
(SAGE Publications Ltd, 2025) Selçuk, Ozan; Phillippo, Kate
Child abuse and neglect remain, unfortunately, a pervasive issue worldwide. Teachers play a critical role in identifying and reporting suspected child abuse and neglect and are often considered the “front line” due to their daily access to children. Although teachers are required to report suspected child abuse and neglect, concerns have arisen about teachers’ capability due to international instances of under- and overreporting. We therefore turned to empirical evidence to better understand teachers’ capacity to serve as accurate, well-informed mandated reporters. This comparative scoping review explored the extent and nature of empirical, peer-reviewed research on teachers’ mandatory reporting in Türkiye and the United States, countries that present contrasts in the mandatory reporting laws’ longevity and cultural norms about responsibility for children’s well-being. We followed Preferred Reporting Items of Systematic Reviews and Meta-Analysis-Scoping Review guidelines. We manually identified studies from seven electronic databases: ASOS Index, DergiPark, ERIC, SCOPUS, SOBIAD, ULAKBİM, and Web of Science. This search process identified 52 empirical studies. Findings shed light on the challenges and concerns surrounding teachers’ mandatory reporting responsibilities in both countries, particularly limited opportunities to learn about reporting requirements, the recognition of abuse and neglect, and multiple rationales for teachers’ hesitancy to report. However, some evidence also indicates the effectiveness of teacher training with regard to teachers’ policy understanding, confidence in recognition skills, and reporting frequency. These findings inform implications for policy development, teacher professional development, and subsequent research in both countries.
