Browsing by Author "Bektaş, Hakan"
Now showing items 1-17 of 17
-
Antimicrobial and antiurease activities of newly synthesized morpholine derivatives containing an azole nucleus
Bektaş, Hakan; Ceylan, Şule; Demirbaş, Neslihan; Alpay-Karaoğlu, Şengül; Sökmen, Bahar Bilgin (Birkhauser Boston, 2013)2-[6-(Morpholin-4-yl)pyridin-3-ylamino]acetohydrazide (4) was obtained starting from 6-morpholin-4-ylpyridin-3-amine (2) via the formation of ester (3) and then converted to the corresponding Schiff bases (5, 6) with the ... -
Design and synthesis of benzimidazole derivatives as apoptosis-inducing agents by targeting Bcl-2 protein
İlhan, Süleyman; Çamlı Pulat, Çisil; Oğuz, Ferdi; Bektaş, Hakan; Menteşe, Emre; Atmaca, Harika (Springer, 2022)Bcl-2, an anti-apoptotic protein, is a well-known and appealing cancer therapy target. Novel series of benzimidazole derivatives were synthesized and tested for their activity as Bcl-2 inhibitors on T98G glioblastoma, PC3 ... -
Design, synthesis, and characterization of some new benzimidazole derivatives and biological evaluation
Bektaş, Hakan; Sökmen, Bahar B.; Aydın, Sinem; Menteşe, Emre; Bektaş, Adile; Dilekci, Gamze (Wiley, 2020)A new series of benzimidazole derivatives (1-15) containing 1,2,4-triazole, 1,3,4-thiadiazole, 1,3,4-oxadiazole, and thiazolidinon rings have been synthesized. All new synthesized benzimidazole compounds were confirmed by ... -
Development of a new and facile carrier element-free coprecipitation procedure for separation, preconcentration and sensitive determination of Cu(II) and Cd(II) Ions in water and vegetable samples
Duran, Celal; Özdeş, Duygu; Menteşe, Emre; Bektaş, Hakan (Taylor & Francis Ltd., 2023)A facile and sensitive method predicated on carrier element free coprecipitation (CEFC) using 2-(2-(2-(4-bromobenzyl)-1H-benzo[d]imidazole-1-yl)acetyl)-N-ethylhydrazine-1-carbothioamide (BIMANEC) is reported for trace ... -
A facile and sensitive coprecipitation method coupled with flame atomic absorption spectrometry for quantification of Cu(II) ions in complex matrices
Özdeş, Duygu; Duran, Celal; Bektaş, Hakan; Menteşe, Emre (Serbian Chemical Society, 2023)In the present investigation, the application of an organic coprecipitant, 2-[5,6-dichloro-2-(2-bromobenzyl)-1H-benzimidazole-1-yl]acetohydrazide (DIBBA), for separation and preconcentration of Cu(II) ions in fruit and ... -
Microwave-assisted synthesis of new benzimidazole derivatives with lipase inhibition activity
Menteşe, Emre; Bektaş, Hakan; Ülker, Serdar; Bekircan, Olcay; Kahveci, Bahittin (Taylor & Francis Ltd, 2014)A practical protocol has been used for the synthesis of benzimidazoles. the reaction of iminoester hydrochlorides of phenylacetic with 4,5-dichloro-1,2-phenylenediamine under microwave irradiation leads to the benzimidazole ... -
New pyridine derivatives as antiurease inhibitors: Synthesis and their evaluation for antimicrobial activities
Bektaş, Hakan; Albay, Canan; Menteşe, Emre; Demirbaş, Neslihan (Editura Acad Romane, 2017)6-Morpholin-4-ylpyridin-3-amine (3) gathered starting from morpholine by two steps was converted into the corresponding arylidenehydrazides through the reaction with several aromatic aldehydes. the treatment of compound 3 ... -
Novel coumarin derivatives containing a triazole moiety: A study on synthesis, cytotoxicity, membrane dysfunction, apoptosis, cell cycle, and antiangiogenic effects
Güner, Adem; Bektaş, Hakan; Menteşe, Emre (Bentham Science Publications, 2022)Background: Coumarin is a functional compound with a pronounced wide range of biological activities and has recently been shown to have anticancer effects on various human cancer cells. Cisplatin is widely used in treating ... -
Preparation and antimicrobial activity evaluation of some quinoline derivatives containing an azole nucleus
Özyanık, Muhammet; Demirci, Serpil; Bektaş, Hakan; Demirbaş, Neslihan; Demirbaş, Ahmet; Karaoğlu, Şengül Alpay (2012)Quinoline-2-carbohydrazide (2) obtained from quinaldic acid (1) was converted to the corresponding carbothioamide 3 and carboxamide 6 by treatment with benzyliso(thio)cyanate. The basic treatment of 3 and 6 yielded the ... -
Structural, spectral, bioactivity, antioxidant and molecular docking (with SARS-CoV-2) analyses on a new synthesized thiosemicarbazide derivative
Güder, Aytaç; Öztürk, Nuri; Alaşalvar, Can; Gökçe, Halil; Menteşe, Emre; Bektaş, Hakan; Albay, Canan (Natl Inst Science Communication & Information Resources-Niscair, 2022)Spectroscopic characterization of the N'-(4-nitrophenylcarbonothioyl) nicotinohydrazide molecule has been studied using both experimental (X-ray diffraction and IR spectroscopy) and quantum mechanical methods. The tautomeric ... -
Synthesis and anticancer activities of some new coumarin derivatives including the triazole ring and their in silico molecular docking studies
Menteşe, Emre; Güner, Adem; Polatlı, Elifsu; Emirik, Mustafa; Bektaş, Hakan; Kahveci, Bahittin (Wiley-V C H Verlag Gmbh, 2020)The synthesis, docking study, and investigation of the anticancer activities of some coumarin derivatives containing the triazole ring are reported in this study. the newly synthesized compounds were screened for their in ... -
Synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives
Bektaş, Hakan; Karaali, Nesrin; Şahin, Deniz; Demirbaş, Ahmet; Karaoğlu, Şengül Alpay; Demirbaş, Neslihan (MDPI, 2010)Some novel 4,5-disubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one (3, 6, 8, 9) derivatives and or 3-(4-methylphenyl)[1,2,4]triazolo[3,4-b][1,3]benzoxazole (5) were synthesized from the reaction of various ester ethoxycarbo ... -
Synthesis and characterization of ring-type and branched polymers including polyethylene glycols by "click" chemistry
Öztürk, Temel; Meyvacı, Ergül; Bektaş, Hakan; Menteşe, Emre (Springer International Publishing Ag, 2019)Synthesis of ring-type (or branched) polymers including polyethylene glycols was archived via "click" chemistry of 5,6-diazido-2-benzyl-1H-benzimidazole (Di-N-3) [or triazidoacetohydrazide derivative (Tri-N-3)] and terminally ... -
Synthesis and molecular docking study of some 5,6-dichloro-2cyclopropyl-1H-benzimidazole derivatives bearing triazole, oxadiazole, and imine functionalities as potent inhibitors of urease
Menteşe, Emre; Bektaş, Hakan; Sökmen, Bahar Bilgin; Emirik, Mustafa; Çakır, Demet; Kahveci, Bahittin (Pergamon-Elsevier Science Ltd, 2017)A new series of benzimidazole compounds including hydrazinecarbothioamide, 1,2,4-triazole, 1,3,4-oxadiazole and imine function were synthesized starting from 5,6-dichloro-2-cyclopropyl-1H-benzimidazole. All of the benzimidazole ... -
Synthesis, antioxidant and antiurease activities of some new 5,6-dichloro-2-(4-fluorobenzyl)-1H-benzimidazolle derivatives containing furan, oxadiazole, triazole and thiadiazole moieties
Bektaş, Hakan; Albay, Canan; Menteşe, Emre; Sökmen, Bahar Bilgin; Kurt, Zafer; Şen, Dilem (Bentham Science Publ Ltd, 2019)Background: Benzimidazoles and its derivatives have been attracting interest for many years because of their biological activities. Benzimidazoles containing different heterocyclic moieties have wide range of biological ... -
Synthesis, antioxidant, and antibacterial activities of some new 2-(3-fluorobenzyl)-1H-benzimidazole derivatives
Bektaş, Hakan; Albay, Canan; Sökmen, Bahar Bilgin; Aydın, Sinem; Menteşe, Emre; Aydın, Gülbahar; Şen, Dilem (Wiley, 2018)A new series of 2-(3-fluorobenzyl)-1H-benzimidazole derivatives containing Schiff base, 1,3,4-oxadiazole, thiosemicarbazide, and 1,3,4-thiadiazole moiety was synthesized. All the synthesized compounds were investigated for ... -
Synthesis, structural, spectral, antioxidant, bioactivity and molecular docking investigations of a novel triazole derivative
Alaşalvar, Can; Öztürk, Nuri; Gökçe, Halil; Güder, Aytaç; Menteşe, Emre; Bektaş, Hakan (Taylor & Francis Ltd., 2021)The structural, spectroscopic and electronic properties of 4-(4-nitrophenyl)-5-(pyridin-3-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione have been analyzed by using single crystal X-ray diffraction (SCXRD), H-1 and C-13 NMR ...
