The protective effects of perindopril against acute kidney damage caused by septic shock
Yılmaz, Hülya Kılıç
Uydu, Hüseyin Avni
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CitationKostakoglu, U., Mercantepe, T., Yilmaz, H.K., Tumkaya, L., Batcik, S., Pinarbas, E., Uydu, H.A. (2021). The protective effects of perindopril against acute kidney damage caused by septic shock. Inflammation, 44(1), 148-159. https://doi.org/10.1007/s10753-020-01316-8
Acute kidney injury (AKI) resulting from septic shock caused by sepsis is an important health problem encountered at rates of 55-73%. Increasing oxidative stress and inflammation following sepsis is a widely observed condition with rising mortality rates. the purpose of this study was to determine whether perindopril (PER) can prevent sepsis-associated AKI with its antioxidant, anti-inflammatory, and anti-apoptotic effects. the control group received an oral saline solution only for 4 days. Cecal ligation and puncture (CLP)-induced sepsis only was applied to the CLP group, while the CLP + PER (2 mg/kg) received CLP-induced sepsis together with 2 mg/kg PER via the oral route for 4 days before induction of sepsis. Finally, all rats were euthanized by anesthesia and sacrificed. TBARS, total SH levels and NF-kappa beta, TNF-alpha, and Caspase-3 expression were then calculated for statistical analysis. TBARS, total SH, NF-k beta/p65, TNF-a, and Caspase-3 levels increased in the CLP group. in contrast, oral administration of PER (2 mg/kg) to septic rats reduced TBARS levels and NF-k beta/p65, TNF-alpha, and Caspase-3 immunopositivity at biochemical analysis. PER treatment appears to be a promising method for preventing sepsis-induced acute kidney injury through its antioxidant anti-inflammation and anti-apoptotic activities.