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dc.contributor.authorPergel, Ahmet
dc.contributor.authorTümkaya, Levent
dc.contributor.authorDemiral, Gökhan
dc.contributor.authorÇolakoğlu, Muhammet Kadri
dc.contributor.authorKalcan, Süleyman
dc.contributor.authorÖzdemir, Ali
dc.contributor.authorMercantepe, Tolga
dc.contributor.authorErdivanlı, Başar
dc.contributor.authorYılmaz, Adnan
dc.date.accessioned2020-12-19T19:34:43Z
dc.date.available2020-12-19T19:34:43Z
dc.date.issued2020
dc.identifier.citationPergel, A., Tümkaya, L., Demiral, G., Çolakoğlu, M. K., Kalcan, S., Özdemir, A., Mercantepe, T., Erdivanlı, B., & Yılmaz, A. (2020). The protective effects of adalimumab on intestinal injury induced with infrarenal aortic occlusion. İnfrarenal aort oklüzyonu ile oluşan intestinal hasarında adalimumab'ın koruyucu etkisi. Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 26(3), 366–372. https://doi.org/10.14744/tjtes.2019.59607en_US
dc.identifier.issn1306-696X
dc.identifier.urihttps://doi.org/10.14744/tjtes.2019.59607
dc.identifier.urihttps://hdl.handle.net/11436/1152
dc.descriptionmercantepe, tolga/0000-0002-8506-1755en_US
dc.descriptionWOS: 000536020600005en_US
dc.descriptionPubMed: 32436975en_US
dc.description.abstractBACKGROUND: the present study aims to observe the effects of ischemia-reperfusion (IR) on small intestines at a molecular level and to prospectively assess the potential preventive role of adalimumab (ADA) and antioxidants. METHODS: A total of 24 male Sprague-Dawley rats were randomly divided into three groups-a control group, an IR group and an IR+ADA group. RESULTS: Although there was no change in SOD levels in the small bowel tissue of the IR group, we observed increased malondialdehyde (MDA) levels and increased numerical density of caspase-3 and TNF-alpha positive enterocytes p=0.00 and p=0.00, respectively). We also observed that IR caused the degeneration of villus crypt structures. CONCLUSION: We found that ADA treatment reduced MDA levels and decreased the numerical density of caspase-3 and TNF-a positive enterocytes compared to the IR group (p=0.00; p=0.011; p=0.00, respectively). We conclude that ADA can be beneficial in preventing intestinal injury that arises from IR.en_US
dc.language.isoengen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdalimumaben_US
dc.subjectIntestinal injuryen_US
dc.subjectIschemiaen_US
dc.subjectOxidative stressen_US
dc.subjectRaten_US
dc.subjectReperfusionen_US
dc.titleThe protective effects of adalimumab on intestinal injury induced with infrarenal aortic occlusionen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorPergel, Ahmet
dc.contributor.institutionauthorTümkaya, Levent
dc.contributor.institutionauthorDemiral, Gökhan
dc.contributor.institutionauthorÇolakoğlu, Muhammet Kadri
dc.contributor.institutionauthorKalcan, Süleyman
dc.contributor.institutionauthorÖzdemir, Ali
dc.contributor.institutionauthorMercantepe, Tolga
dc.contributor.institutionauthorErdivanlı, Başar
dc.contributor.institutionauthorYılmaz, Adnan
dc.identifier.doi10.14744/tjtes.2019.59607
dc.identifier.volume26en_US
dc.identifier.issue3en_US
dc.identifier.startpage366en_US
dc.identifier.endpage372en_US
dc.ri.editoaen_US
dc.relation.journalUlusal Travma ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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