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dc.contributor.authorMercantepe, Tolga
dc.contributor.authorÜnal, Deniz
dc.contributor.authorTümkaya, Levent
dc.contributor.authorYazıcı, Zihni Açar
dc.date.accessioned2020-12-19T19:41:52Z
dc.date.available2020-12-19T19:41:52Z
dc.date.issued2018
dc.identifier.citationMercantepe, T., Unal, D., Tümkaya, L., & Yazici, Z. A. (2018). Protective effects of amifostine, curcumin and caffeic acid phenethyl ester against cisplatin-induced testis tissue damage in rats. Experimental and therapeutic medicine, 15(4), 3404–3412. https://doi.org/10.3892/etm.2018.5819en_US
dc.identifier.issn1792-0981
dc.identifier.issn1792-1015
dc.identifier.urihttps://doi.org/10.3892/etm.2018.5819
dc.identifier.urihttps://hdl.handle.net/11436/1842
dc.descriptionMercantepe, Tolga/0000-0002-8506-1755; Yazici, Zihni Acar/0000-0003-1603-6545en_US
dc.descriptionWOS: 000428945200034en_US
dc.descriptionPubMed: 29545862en_US
dc.description.abstractCisplatin is an effective antineoplastic drug that is usually used to treat a number of different types of cancer in the clinic. One of the most notable side effects of cisplatin use is infertility. the present study was designed to determine the non-oxidative testicular effects caused by the use of cisplatin in rats. the rats were randomly allocated to the experimental groups. the untreated rats represented the control group (group I) and the treatment groups were as follows: cisplatin alone (group II), cisplatin+amifostine (group III), cisplatin+curcumin (group IV), and cisplatin+caffeic acid phenethyl ester (CAPE; group V). the present study observed that following cisplatin administration, the expression of nuclear factor-B (NF-)/p65, caspase-3 and 8-deoxyguanosine (8-OHdG) increased in germinal epithelium and Leydig cells. However, the expression of these markers decreased in groups III-V, most notably in the group treated with amifostine. cisplatin induced-damage was countered by amifostine and curcumin. the results revealed that the activation of NF-B, caspase-3 and 8-OHdG had a significant role in cisplatin-induced testicular toxicity. Thus, amifostine, curcumin and, to a lesser extent, CAPE have the potential for use as therapeutic adjuvants in cisplatin-induced testis injury.en_US
dc.language.isoengen_US
dc.publisherSpandidos Publ Ltden_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAmifostineen_US
dc.subjectCaffeic acid phenethyl esteren_US
dc.subjectCisplatinen_US
dc.subjectCurcuminen_US
dc.subjectTestisen_US
dc.titleProtective effects of amifostine, curcumin and caffeic acid phenethyl ester against cisplatin-induced testis tissue damage in ratsen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorMercantepe, Tolga
dc.contributor.institutionauthorTümkaya, Levent
dc.contributor.institutionauthorYazıcı, Zihni Açar
dc.identifier.doi10.3892/etm.2018.5819
dc.identifier.volume15en_US
dc.identifier.issue4en_US
dc.identifier.startpage3404en_US
dc.identifier.endpage3412en_US
dc.ri.editoaen_US
dc.relation.journalExperimental and Therapeutic Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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