Yazar "Karaoğlu, Şengül Alpay" için Fen Edebiyat Fakültesi listeleme
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Structure-based hybridization, microwave prompted synthesis and biological evaluation of novel 4-(2-fluoro-4-nitrophenyl)morpholine derivatives
Cebeci, Yıldız Uygun; Demirbaş, Neslihan; Özdemir, Serap Başoğlu; Bayrak, Hacer; Demirbaş, Ahmet; Aksakal, Fatma; Karaoğlu, Şengül Alpay (Bentham Science Publ Ltd, 2018)1,3,4-oxadiazole-2-thiole 6 was obtained from 4-(2-fluoro-4-nitrophenyl)morpholine (2) by the reduction of its nitro group and the sequential treatment of the resulting amine with ethyl bro-moacetate, hydrazine hydrate, ... -
Syntheses and biological activities of new hybrid molecules containing different heterocyclic moieties
Ceylan, Şule; Bektaş, Hakan; Bayrak, Hacer; Demirbaş, Neslihan; Karaoğlu, Şengül Alpay; Ülker, Serdar (Wiley, 2013)4-Aryl-5-(pyridin-3-yl)-4H-1,2,4-triazole-3-(thi)oles 5-7, obtained starting from nicotinic acid hydrazide were converted to the corresponding Mannich bases 12-24 by the reaction with several heterocyclic amines in the ... -
Synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives
Bektaş, Hakan; Karaali, Nesrin; Şahin, Deniz; Demirbaş, Ahmet; Karaoğlu, Şengül Alpay; Demirbaş, Neslihan (MDPI, 2010)Some novel 4,5-disubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one (3, 6, 8, 9) derivatives and or 3-(4-methylphenyl)[1,2,4]triazolo[3,4-b][1,3]benzoxazole (5) were synthesized from the reaction of various ester ethoxycarbo ... -
Synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives
Bayrak, Hacer; Demirbaş, Ahmet; Bektaş, Hakan; Karaoğlu, Şengül Alpay; Demirbaş, Neslihan (TUBİTAK, 2010)The synthesis of ethyl [3-(cyanomethyl)-5-alkyl-4H-1,2,4-triazol-4-yl] carbamates (2a-d) was performed starting from ethyl 2-[ethoxy(4-(aryl)methylene] hydrazinecarboxylates (1a, 1b). The treatment of 2a with thiosemicarbazide ... -
Synthesis and antimicrobial activities of some new biheterocyclic compounds containing 1, 2, 4-triazol-3-one and 1, 3, 4-thiadiazole moieties
Bektaş, Hakan; Demirbaş, Ahmet; Demirbaş, Neslihan; Bayrak, Hacer; Karaoğlu, Şengül Alpay (TÜBİTAK, 2010)2-(4-Amino-3-(4-chlorophenyl)-5-oxo-4, 5-dihydro-1 H-1, 2, 4-triazol-1-yl)-N'-[(2, 6 dihalogenophenyl)-methylene]acetohydrazides (3a, b) was obtained via the formation of 2-(4-amino-3-(4-chlorophenyl)-5-oxo-4, 5-dihydro-1 ... -
Synthesis and antimicrobial activity evaluation of new norfloxacine-azole hybrids
Demirci, Serpil; Demirbaş, Neslihan; Menteşe, Meltem; Özdemir, Serap Başoğlu; Karaoğlu, Şengül Alpay (Walter de Gruyter Gmbh, 2018)Norfloxacin-azole hybrids 3 and 6a,b were synthesized starting from norfloxacin. the treatment of these compounds with amines as a one-pot three-component reaction produced the corresponding amino derivatives 4a,b, 7a-g ... -
Synthesis and antimicrobial activity of methoxy azachalcones and N-Alkyl substituted methoxy azachalconium bromides
Albay, Canan; Kahriman, Nuran; Yılmaz Iskender, Nagihan; Karaoğlu, Şengül Alpay; Yaylı, Nurettin (TÜBİTAK, 2011)In this study, 18 new N-octyl, N-decyl, and N-dodecyl substituted o-, m-, and p-methoxy (E)-3-and 4-azachalcones, {4-or 3-[(1E)-3-(4-, 3-, or 2-methoxyphenyl)-3-oxoprop-1-en-1-yl]-1-alkyl (C8,10,12) pyridinium bromides} ... -
Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds
Özdemir, Serap Başoğlu; Cebeci, Yıldız Uygun; Bayrak, Hacer; Mermer, Arif; Ceylan, Şule; Demirbaş, Ahmet; Karaoğlu, Şengül Alpay; Demirbaş, Neslihan (Walter de Gruyter Gmbh, 2017)The hydrazide 5, that was obtained from -1-(4-fluorophenyl) piperazine (1), was converted to the cor-responding carbothioamides 6a-c by the reaction with alkyl(aryl) isothiocyanates. the synthesis of conazole analogs 10a-f ... -
Synthesis and antimicrobial, antiproliferative evaluation of novel quinolone and conazole analogues via conventional and microwave techniques
Ceylan, Şule; Cebeci, Yıldız Uygun; Karaoğlu, Şengül Alpay; Altun, Muhammed (Wiley, 2021)1,2,4-Triazole-3-one (3), acquired from cinnamaldehyde was converted to the corresponding carbox(thio)amides via several steps (6 a-c). Their reaction with sodium hydroxide gave the 1,2,4-triazole derivatives (7 a-c). ... -
Synthesis and biological activity studies of new hybrid molecules containing tryptamine moiety
Bektaş, Hakan; Demirbaş, Ahmet; Demirbaş, Neslihan; Karaoğlu, Şengül Alpay (Springer, 2012)The synthesis of N?-(4-substitutedphenylsulfonyl)-2-{4-[2-(1H-indol- yl)ethyl]-3-(4-chlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl} acetohydrazides (3a-c), 2-{4-[2-(1H-indol-3-yl)ethyl]-3-(4-chlorobenzyl)-5-oxo- ... -
Synthesis and biological evaluation of a new series of 4-alkoxy-2-arylquinoline derivatives as potential antituberculosis agents
Tosun, Gonca; Arslan, Tayfun; İskefiyeli, Zeynep; Küçük, Murat; Karaoğlu, Şengül Alpay; Yaylı, Nurettin (2015)Three new series of 33 quinolone compounds, 2-(2-, 3-, and 4-fluorophenyl)-4-O-alkyl(C5−15) quinolines (7a– k, 8a–k, and 9a–k), were synthesized from 2-(2-, 3-, and 4-fluorophenyl)-2,3-dihydroquinolin-4(1H )-one (4, ... -
Synthesis of eperezolid-like molecules and evaluation of their antimicrobial activities
Yolal, Meltem; Başoğlu, Serap; Bektaş, Hakan; Demirci, Serpil; Karaoğlu, Şengül Alpay; Demirbaş, Ahmet (Springer Link, 2012)3-Fluoro-4-(4-phenylpiperazin-l-yl)aniline (II) prepared from 3,4-difluoro nitrobenzene was converted to the corresponding Schiff bases (III) and (IV) by treatment with 4-methoxybenzaldehyde and indol-3-carbaldehyde, ... -
Synthesis of hydroxy benzoin/benzil analogs and investigation of their antioxidant, antimicrobial, enzyme inhibition, and cytotoxic activities
Yaylı, Nurettin; Kılıç, Gözde; Çelik, Gözde; Kahriman, Nuran; Kanbolat, Şeyda; Bozdeveci, Arif; Karaoğlu, Şengül Alpay; Aliyazıcıoğlu, Rezzan; Sellitepe, Hasan Erdinç; Doğan, İnce Selin; Aydın, Ali (Scientific Technical Research Council Turkey - TUBİTAK, 2021)In this study, hydroxy benzoin (1-7), benzil (8-14), and benzoin/benzil-O-beta-D-glucosides (15-25) were synthesized to investigate their biological activities. An efficient method for synthesizing hydroxy benzoin compounds ... -
Synthesis of methyl (E)-2′,4″-thiazachalcones and their N-alkyl derivatives, photochemistry with theoretical calculations and antimicrobial activities
Usta, Asu; Yaşar, Ahmet; Yaylı, Nuran; Karaoğlu, Şengül Alpay; Yaylı, Nurettin (TUBİTAK, 2009)A series of 9 new (E) -thiazachalcones (1-3), and their N -alkyl substituted derivatives (4-6), and stereoselective dimerization products (7-9) were synthesized, then tested for antimicrobial activity against all test ... -
Synthesis of novel antipyrine derivatives possessing remarkable antimicrobial activities
Bayrak, Hacer; Cebeci, Yıldız Uygun; Karaoğlu, Şengül Alpay (Wiley-V C H Verlag Gmbh, 2019)In this study, new triazole, thiazole, oxazole and Mannich bases were synthesized starting from antipyrine. All the newly synthesized compounds were screened for their antimicrobial activities against some test microorganisms ... -
Synthesis of novel antipyrine-azole-S-alkyl derivatives antimicrobial activity, molecular docking, and computational studies
Cebeci, Yıldız Uygun; Bayrak, Hacer; Karaoğlu, Şengül Alpay; Fahim, Asmaa M. (Elsevier, 2022)In this investigation, we synthesized the newly antipyrine-azole-S-alkyl and their reduction derivatives that were screened for their antimicrobial activity and compared them with molecular docking and computational Studies. ... -
Synthesis of novel symmetrical 1,4-disubstituted 1,2,3-bistriazole derivatives via 'click chemistry' and their biological evaluation
Düğdü, Esra; Unluer, Dilek; Çelik, Fatih; Sancak, Kemal; Karaoğlu, Şengül Alpay; Özel, Arzu (Mdpi, 2016)A series of symmetric bis-1,2,3-triazole compounds 2-5(a-f) were synthesized as potential antioxidant agents via click chemistry. Their structures were confirmed by H-1-NMR and C-13-NMR. All of the synthesized compounds ... -
Synthesis of some new 1,2,4-triazoles starting from isonicotinic acid hydrazide and evaluation of their antimicrobial activities
Bayrak, Hacer; Demirbağ, Ahmet; Demirbaş, Neslihan; Karaoğlu, Şengül Alpay (Elsevier, 2009)5-Pyridin-4-yl-1,3,4-oxadiazole-2-thiol (2) was obtained from the reaction of isonicotinic acid hydrazide with carbon disulfide in basic media and converted into 4-amino-5-pyridin-4-yl-4H-1,2,4-triazole-3-thiol (5) by the ... -
Synthesis of some new 1,2,4-triazoles, their Mannich and Schiff bases and evaluation of their antimicrobial activities
Bayrak, Hacer; Demirbaş, Ahmet; Karaoğlu, Şengül Alpay; Demirbaş, Neslihan (Elsevier, 2009)4-Phenyl-5-pyridin-4-yl-4H-1,2,4-triazole-3-thiol (3) was obtained in basic media via the formation of 2-isonicotinoyl-N-phenylhydrazinecarbothioamide (2), and converted to some alkylated derivatives (4a,b) and Mannich ... -
Synthesis of some new 1,3,4-thiadiazol-2-ylmethyl-1,2,4-triazole derivatives and investigation of their antimicrobial activities
Demirbaş, Ahmet; Şahin, Deniz; Demirbaş, Neslihan; Karaoğlu, Şengül Alpay (Elsevier, 2009)4-Amino-2-[(5-arylamino-4,5-dihydro-1,3,4-thiadiazol-2-yl)methyl]-5-(4-methylphenyl)-2,4-dihydro-3H-1,2,4-triazol-3-ones (3a-c) were obtained in acidic media via the formation of 2-[(4-amino-3-aryl-5-oxo-4,5-dihydro-1H-1 ...