Yazar "Tümkaya, Levent" için TF, Temel Tıp Bilimleri Bölümü Koleksiyonu listeleme
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The protective effects of perindopril against acute kidney damage caused by septic shock
Kostakoğlu, Uğur; Mercantepe, Tolga; Yılmaz, Hülya Kılıç; Tümkaya, Levent; Batçık, Şule; Pınarbaş, Esra; Uydu, Hüseyin Avni (Springer/Plenum Publishers, 2021)Acute kidney injury (AKI) resulting from septic shock caused by sepsis is an important health problem encountered at rates of 55-73%. Increasing oxidative stress and inflammation following sepsis is a widely observed ... -
The protective effects of red ginseng and amifostine against renal damage caused by ionizing radiation
Yılmaz, Hamit; Karakoç, Yunus; Tümkaya, Levent; Mercantepe, Tolga; Sevinç, Hacer; Yılmaz, Adnan; Rakıcı, Sema Yılmaz (2022)This study aimed to elucidate the effects of amifostine (ethyol) (AM), a synthetic radioprotector, and red ginseng (RG), a natural radioprotective agent, against the toxic effect of ionizing radiation (IR) on kidney tissues ... -
The protective effects of topiramate on intestinal injury induced with infrarenal aortic occlusion via oxidative stress and apoptosis
Pergel, Ahmet; Demiral, Gökhan; Tümkaya, Levent; Mercantepe, Tolga; Özdemir, Ali; Kalcan, Süleyman; Çolakoğlu, Muhammed Kadri; Yılmaz, Adnan; Bedir, Recep; Karakaya, Ahmet (Taylo & Francis Ltd., 2021)Purpose: Prolonged surgical procedures and some clinical conditions such as surgeries of thoracoabdominal aorta, mesenteric ischemia, cardiopulmonary bypass, strangulated hernias and neonatal necrotizing enterocolitis may ... -
Protective effects of tumor necrosis factor alpha inhibitors on methotrexate-induced pancreatic toxicity
Mercantepe, Tolga; Kalkan, Yıldıray; Tümkaya, Levent; Şehitoğlu, İbrahim; Mercantepe, Filiz; Yıldırmış, Sermet (Wroclaw Medical Univ, 2018)Background. Methotrexate (MTX), a folate antagonist, is commonly used in the treatment of many different types of cancer and inflammatory diseases, including pancreatic cancer, although its side effects on the pancreas ... -
The protective effects of whortleberry extract against cisplatin-induced ototoxicity in rats
Özdemir, Doğukan; Özgür, Abdulkadir; Kalkan, Yıldıray; Terzi, Suat; Tümkaya, Levent; Yılmaz, Adnan; Çeliker, Metin; Dursun, Engin (Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, 2019)Introduction: Cisplatin is one of the main chemotherapeutic agents used for the treatment of many types of cancer. However, ototoxicity, one of the most serious side effects of cisplatin, extract restricts its usage. ... -
The protective role of fosfomycin in lung injury due to oxidative stress and inflammation caused by sepsis
Yıldız, İlknur Esen; Topçu, Atilla; Bahçeci, İlkay; Arpa, Medeni; Tümkaya, Levent; Mercantepe, Tolga; Batçık, Şule; Yıldız, Yasin (Pergamon-Elsevier Science Ltd., 2021)Aim: Early and prompt treatment of sepsis by effective antibiotics against susceptible organisms may be lifesaving. However, increased antibiotic resistance and side effects of chemotherapeutic agents limiting their ... -
Radioprotective effect of endogenous melatonin secretion associated with the circadian rhythm in irradiated rats
Rakıcı, Sema Yılmaz; Tümkaya, Levent; Erdivanlı, Özlem Çelebi; Yazıcı, Ufuk; Dursun, Engin; Arpa, Medeni; Mercantepe, Tolga (Taylor & Francis Ltd, 2019)Purpose: We investigated the radioprotective effect of endogenous melatonin release at different times associated with the circadian rhythm on head and neck radiotherapy. Materials and methods: Two groups of animals were ... -
The radioprotective effect of N-acetylcysteine against x-radiation-induced renal injury in rats
Mercantepe, Tolga; Topçu, Atilla; Rakıcı, Sema; Tümkaya, Levent; Yılmaz, Adnan; Mercantepe, Filiz (Springer Heidelberg, 2019)The purpose of this study was therefore to investigate the effects of radiotherapy on the kidney and the potential use of agents such as N-acetylcysteine (NAC) in developing a future therapeutic protocol for radiation-induced ... -
Radioprotective effects of alpha 2-adrenergic receptor agonist dexmedetomidine on X-ray irradiation-induced pancreatic islet cell damage
Mercantepe, Filiz; Tümkaya, Levent; Mercantepe, Tolga; Rakıcı, Sema Yılmaz; Çiftel, Serpil; Çiftel, Sedat (Springer, 2023)Comprehensive epidemiological analyses conducted in the last 30 years have revealed a link between radiation and DM. We aimed to determine the effects of dexmedetomidine pretreatment on radiation-induced pancreatic islet ... -
Radioprotective effects of dexmedetomidine on X-ray-induced testicular damage
Dil, Eyüp; Tümkaya, Levent; Mercantepe, Tolga; Rakıcı, Sema Yılmaz; Yılmaz, Adnan; Samancı, Tuğba Çelik; Yazıcı, Zihni Açar (Verduci Publisher, 2023)OBJECTIVE: Approximately 70% of cancer patients require radiotherapy. However, despite its effectiveness in the treatment of cancer, radiotherapy can also affect and damage surrounding healthy tissues in addition to ... -
Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture
Karakişi, Sedat Ozan; Hemşinli, Doğuş; Tümkaya, Levent; Ergene, Şaban; Mercantepe, Tolga; Yılmaz, Adnan (Baycinar Medical Publishing-Bayçınar Tıbbi Yayıncılık, 2021)Background: The aim of this study was to examine the effects on the lungs of ischemia/reperfusion injury in a ruptured abdominal aortic aneurysm model in rats and to investigate the potential protective effects of ... -
Resveratrol attenuates degeneration and apoptosis of cardiomyocytes induced by aortic clamping
Ergene, Şaban; Hemşinli, Doğuş; Karakişi, Sedat Ozan; Tümkaya, Levent; Mercantepe, Tolga; Yılmaz, Adnan; Yel, İbrahim (2023)Introduction: Objective: To investigate the potential beneficial effects of resveratrol (RVT) against ischemia-reperfusion injury of myocardial tissue during surgical treatment of ruptured abdominal aortic aneurysm. Methods: ... -
Resveratrol prevents acute renal injury in a model of ruptured abdominal aortic aneurysm
Hemşinli, Doğuş; Tümkaya, Levent; Ergene, Şaban; Karakişi, Sedat Ozan; Mercantepe, Tolga; Çınar, Şenay Burak; Yılmaz, A. (Sage Publications Ltd, 2021)Objective: To examine the biochemical and histopathological effects of ischemia/reperfusion (I/R) injury in a ruptured abdominal aortic aneurysm (RAAA) model in rats, and to investigate the potential protective role of ... -
Reversal of rocuronium-induced neuromuscular block with sugammadex and resulting histopathological effects in rat kidneys
Bostan, Habib; Kalkan, Yıldıray; Tomak, Yakup; Tümkaya, Levent; Altuner, Durdu; Yılmaz, Adnan; Erdivanlı, Başar; Bedir, Recep (Taylor & Francis, 2011)Background: This study investigated the effect of injection of rocuronium or sugammadex alone and rocuronium + sugammadex on urea, creatinine, electrolyte levels, and histopathological findings in rats. Methods: Thirty-six ... -
The role of vaccinium myrtillus in the prevention of renal injury in an experimental model of ruptured abdominal aortic aneurysm
Ergene, Şaban; Hemşinli, Doğuş; Karakişi, Sedat Ozan; Mercantepe, Tolga; Tümkaya, Levent; Yılmaz, Adnan (Soc Brasil Cirurgia Cardiovasc, 2020)Objective: To examine the biochemical and histopathological renal effects of ischemia/reperfusion (I/R) injury using a ruptured abdominal aortic aneurysm (RAAA) model in rats and to investigate the potential protective ... -
Sciatic nerve injury following analgesic drug injection in rats: a histopathological examination
Bostan, Habib; Çabalar, Murat; Altınay, Serdar; Kalkan, Yıldıray; Tümkaya, Levent; Kanat, Ayhan; Koçer, Abdulkadir (Kare PUBL, 2018)OBJECTIVE: Sciatic nerve neuropathy can be observed following intramuscular gluteal injections. The histopathological examination of sciatic nerve damage following intramuscular injection in the gluteal region for acute ... -
Tea grape reduces abdominal aortic occlusion-induced lung injury
Hemşinli, Doğuş; Ergene, Şaban; Karakişi, Sedat Ozan; Mercantepe, Tolga; Tümkaya, Levent; Yılmaz, Adnan; Akyıldız, Kerimali (Soc Brasil Cirurgia Cardiovasc, 2020)Introduction: Ischemia-associated mortality caused by aortic cross-clamps, as in ruptured abdominal aorta aneurysm surgeries, and reperfusion following their removal represent some of the main emergency conditions in ... -
The therapeutic effect of thymoquinone on acoustic trauma-induced hearing loss in rats
Oğurlu, Mahmut; Erdivanlı, Özlem Çelebi; Tümkaya, Levent; Özgür, Abdulkadir; Coşkun, Zerrin Özergin; Terzi, Suat; Demirci, Münir; Dursun, Engin (Springer, 2017)Thymoquinone has antioxidant properties. We hypothesized that thymoquinone may prevent or alleviate hearing loss induced by acoustic trauma. We aimed to study thymoquinone's effect on hearing function with distortion-product ... -
Topiramate ameliorates abdominal aorta cross-clamping induced liver injury in rats
Cüre, Erkan; Cüre, Medine Cumhur; Tümkaya, Levent; Kalkan, Yıldıray; Aydın, İbrahim; Kırbaş, Aynur; Yılmaz, Arif; Yüce, Süleyman; Gökçe, Mehmet Fatih (Wolters Kluwer Medknow Publications, 2014)Background and Aim: Ischemia/reperfusion (I/R) injury in the liver occurs after a prolonged period of ischemia followed by restoration of hepatic blood perfusion. During the surgery of abdominal aorta, I/R injury causes ...