Yazar "Yılmaz, Adnan" için TF, Temel Tıp Bilimleri Bölümü Koleksiyonu listeleme
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Preventive effects of melatonin on periodontal tissue destruction due to psychological stress in rats with experimentally induced periodontitis
Bostan, Semih Alperen; Yemenoğlu, Hatice; Köse, Oğuz; Akyıldız, Kerimali; Mercantepe, Tolga; Saral, Sinan; Tümkaya, Levent; Yılmaz, Adnan (Wiley, 2024)Objective and Background: Psychological stress is a potential modifiable environmental risk factor causally related to the exacerbation of periodontitis and other chronic inflammatory diseases. This animal study aimed to ... -
The protective effect of astaxanthin against cisplatin-induced nephrotoxicity in rats
Akça, Görkem; Eren, Hüseyin; Tümkaya, Levent; Mercantepe, Tolga; Horsanali, Mustafa Ozan; Deveci, Ezgi; Yılmaz, Adnan (Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)Purpose: the aim of this experimental study was to investigate the antioxidant effects of astaxanthin against cisplatin-induced nephrotoxicity in rats. Methods: Forty-eight male Sprague-Dawley rats weighing 264.83 +/- 7.39 ... -
The protective effect of astaxanthin on cisplatin-induced ototoxicity
Terzi, Suat; Özgür, Abdulkadir; Çeliker, Metin; Mercantepe, Tolga; Yılmaz, Adnan; Tümkaya, Levent; Kaya, Şeyma; Demir, Emine; Dursun, Engin (Wroclaw Medical Univercity, 2021)Background. Promising studies have been conducted with many substances to reduce the ototoxic effects of cisplatin, but there is no treatment that completely eliminates the ototoxic effect. Objectives. To determine the ... -
Protective effect of tea grape extract on cisplatin-induced muscle atrophy: A morphological study
Balık, Mehmet Sabri; Tümkaya, Levent; Mercantepe, Tolga; Yılmaz, Adnan; Balık, Gülşah; Topçu, Atilla; Yazıcı, Zihni Açar (Kowsar Publ, 2018)Background: Even though Cisplatin (Cis) is known to be organotoxic, it is used in neoplastic chemotherapy. in skeletal muscles, the toxic effect manifests as atrophy. Objectives: the tea grape extract (TGE) is a sort of ... -
Protective effect of vaccinium myrtillus extract on x-ray irradiation-induced retinal toxicity via enos and 8-ohdgexpression
Fındık, Hüseyin; Aslan, Mehmet Gökhan; Okutucu, Murat; Yılmaz, Adnan; Tümkaya, Levent; Mercantepe, Tolga; Akyıldız, Kerimali; Uzun, Fatma (Karger, 2023)Every year, hundreds of thousands of cancer patients receive radiotherapy treatment. Oxidative stress is observed in healthy tissues due to irradiation exposure. The present study is the first to address the effects of ... -
Protective effect of whortleberry extract on salivary gland damage induced by neck irradiation in rats
Özgür, Abdulkadir; Terzi, Suat; Özdemir, Doğukan; Tümkaya, Levent; Rakıcı, Sema; Mercantepe, Tolga; Yılmaz, Adnan; Çeliker, Metin; Dursun, Engin (Sage Publications Inc, 2019)Radiotherapy is a method of treatment used on malignant head and neck tumors; however, it may lead to adverse effects by influencing other tissues because its effects are not specific to tumor tissues. These adverse effects ... -
The protective effects of adalimumab on intestinal injury induced with infrarenal aortic occlusion
Pergel, Ahmet; Tümkaya, Levent; Demiral, Gökhan; Çolakoğlu, Muhammet Kadri; Kalcan, Süleyman; Özdemir, Ali; Mercantepe, Tolga; Erdivanlı, Başar; Yılmaz, Adnan (Turkish Assoc Trauma Emergency Surgery, 2020)BACKGROUND: the present study aims to observe the effects of ischemia-reperfusion (IR) on small intestines at a molecular level and to prospectively assess the potential preventive role of adalimumab (ADA) and antioxidants. ... -
Protective effects of amifostine, curcumin, and melatonin against cisplatin-induced acute kidney injury
Mercantepe, Filiz; Mercantepe, Tolga; Topçu, Atilla; Yılmaz, Adnan; Tümkaya, Levent (Springer, 2018)Despite the enormous advances made in the field of oncology, no solution to the side effect of nephrotoxicity caused by cisplatin used as an antineoplastic agent for approximately 40 years has yet been discovered. This ... -
The protective effects of astaxanthin against cisplatin-induced retinal toxicity
Fındık, Hüseyin; Tümkaya, Levent; Yılmaz, Adnan; Aslan, Mehmet Gökhan; Okutucu, Murat; Akyıldız, Kerimali; Mercantepe, Tolga (Taylor & Francis Ltd, 2019)Purpose: This study investigated the toxic effects of an antineoplastic agent, cisplatin (CIS), on retinal cells and the potential capacity of astaxanthin (ASTA) to elicit a future therapeutic protocol in CIS-induced retinal ... -
Protective effects of nebivolol on ovarian ischemia-reperfusion injury in rat
Çolak, Sabri; Gürlek, Beril; Topçu, Atilla; Tümkaya, Levent; Mercantepe, Tolga; Yılmaz, Adnan (Wiley, 2020)Aim Ovarian torsion is a common gynecological emergency of reproductive ages, occurring at rates of 2.7-7.4%. This study aimed to evaluate the antioxidant effects of Nebivolol (NEB) and histopathological changes in ... -
The protective effects of red ginseng and amifostine against renal damage caused by ionizing radiation
Yılmaz, Hamit; Karakoç, Yunus; Tümkaya, Levent; Mercantepe, Tolga; Sevinç, Hacer; Yılmaz, Adnan; Rakıcı, Sema Yılmaz (2022)This study aimed to elucidate the effects of amifostine (ethyol) (AM), a synthetic radioprotector, and red ginseng (RG), a natural radioprotective agent, against the toxic effect of ionizing radiation (IR) on kidney tissues ... -
The protective effects of topiramate on intestinal injury induced with infrarenal aortic occlusion via oxidative stress and apoptosis
Pergel, Ahmet; Demiral, Gökhan; Tümkaya, Levent; Mercantepe, Tolga; Özdemir, Ali; Kalcan, Süleyman; Çolakoğlu, Muhammed Kadri; Yılmaz, Adnan; Bedir, Recep; Karakaya, Ahmet (Taylo & Francis Ltd., 2021)Purpose: Prolonged surgical procedures and some clinical conditions such as surgeries of thoracoabdominal aorta, mesenteric ischemia, cardiopulmonary bypass, strangulated hernias and neonatal necrotizing enterocolitis may ... -
The protective effects of whortleberry extract against cisplatin-induced ototoxicity in rats
Özdemir, Doğukan; Özgür, Abdulkadir; Kalkan, Yıldıray; Terzi, Suat; Tümkaya, Levent; Yılmaz, Adnan; Çeliker, Metin; Dursun, Engin (Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, 2019)Introduction: Cisplatin is one of the main chemotherapeutic agents used for the treatment of many types of cancer. However, ototoxicity, one of the most serious side effects of cisplatin, extract restricts its usage. ... -
The radioprotective effect of N-acetylcysteine against x-radiation-induced renal injury in rats
Mercantepe, Tolga; Topçu, Atilla; Rakıcı, Sema; Tümkaya, Levent; Yılmaz, Adnan; Mercantepe, Filiz (Springer Heidelberg, 2019)The purpose of this study was therefore to investigate the effects of radiotherapy on the kidney and the potential use of agents such as N-acetylcysteine (NAC) in developing a future therapeutic protocol for radiation-induced ... -
Radioprotective effects of dexmedetomidine on X-ray-induced testicular damage
Dil, Eyüp; Tümkaya, Levent; Mercantepe, Tolga; Rakıcı, Sema Yılmaz; Yılmaz, Adnan; Samancı, Tuğba Çelik; Yazıcı, Zihni Açar (Verduci Publisher, 2023)OBJECTIVE: Approximately 70% of cancer patients require radiotherapy. However, despite its effectiveness in the treatment of cancer, radiotherapy can also affect and damage surrounding healthy tissues in addition to ... -
Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture
Karakişi, Sedat Ozan; Hemşinli, Doğuş; Tümkaya, Levent; Ergene, Şaban; Mercantepe, Tolga; Yılmaz, Adnan (Baycinar Medical Publishing-Bayçınar Tıbbi Yayıncılık, 2021)Background: The aim of this study was to examine the effects on the lungs of ischemia/reperfusion injury in a ruptured abdominal aortic aneurysm model in rats and to investigate the potential protective effects of ... -
Resveratrol attenuates degeneration and apoptosis of cardiomyocytes induced by aortic clamping
Ergene, Şaban; Hemşinli, Doğuş; Karakişi, Sedat Ozan; Tümkaya, Levent; Mercantepe, Tolga; Yılmaz, Adnan; Yel, İbrahim (2023)Introduction: Objective: To investigate the potential beneficial effects of resveratrol (RVT) against ischemia-reperfusion injury of myocardial tissue during surgical treatment of ruptured abdominal aortic aneurysm. Methods: ... -
Reversal of rocuronium-induced neuromuscular block with sugammadex and resulting histopathological effects in rat kidneys
Bostan, Habib; Kalkan, Yıldıray; Tomak, Yakup; Tümkaya, Levent; Altuner, Durdu; Yılmaz, Adnan; Erdivanlı, Başar; Bedir, Recep (Taylor & Francis, 2011)Background: This study investigated the effect of injection of rocuronium or sugammadex alone and rocuronium + sugammadex on urea, creatinine, electrolyte levels, and histopathological findings in rats. Methods: Thirty-six ... -
The role of serum interleukin-37 levels, inflammation and blood pressure in patients with preeclampsia
Şatıroğlu, Ömer; Gürlek, Beril; Durakoğlugil, Murtaza Emre; Duman, Hakan; Erdoğan, Turan; Çetin, Mustafa; Ergül, Muhammet; Yılmaz, Adnan; Uydu, Hüseyin Avni (Taylor and Francis Ltd, 2020)Aim: Preeclampsia is one of the major causes of perinatal, fetal, and maternal mortality and morbidity. The aim of this study was to investigate the association of serum interleukin 37 (IL 37) with preeclampsia. Methods: ...