Yazar "Tümkaya, Levent" için TF, Temel Tıp Bilimleri Bölümü Koleksiyonu listeleme
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Lasting hepatotoxic effects of prenatal mobile phone exposure
Yılmaz, Adnan; Tümkaya, Levent; Akyıldız, Kerimali; Kalkan, Yıldıray; Bodur, Ali Fuat; Sargın, Fatma; Efe, Hasan; Uydu, Hüseyin Avni; Yazıcı, Zihni Açar (Taylor & Francis Ltd, 2017)Objective: in this study, the livers of rats born to mothers exposed to electromagnetic field (EMF) were examined 60 days postpartum for biochemical and histopathological changes.Methods: Pregnant rats were exposed to ... -
Less use of the bipolar cautery can prevent postlaminectomy epidural fibrosis: an experimental study in rats
AIM: To investigate the role of bipolar electrocautery in the occurrence of epidural fibrosis following lumbar spine laminectomy in a rat model. MATERIAL and METHODS: Fourteen male Sprague–Dawley rats (age: 4–6 months, ... -
Light color changes the density and height of synapses in an area of the brain essential for learning
The effects of pre and post-passive avoidance training, and exposure to different wavelengths of light on numerical synapse density and the mean projected synapse height in the intermediate and medial part of the hyperstriatum ... -
Long-term protective effects of lamotrigine in a rat ovarian ischemia-reperfusion model
Aktepe, Rıza; Üçüncü, Yılmaz; Tümkaya, Levent; Mercantepe, Tolga; Topçu, Atilla; Uydu, Hüseyin Avni; Atak, Mehtap (Elsevier, 2024)Ovarium torsion is a gynecological emergency that is common in women of reproductive age and requires early diagnosis and intervention. In this study, we aimed to investigate the long-term anatomical, histological and ... -
Manyetik Rezonans Kontrast Ajanların Sıçan Beyni Üzerine Etkilerinin Histopatolojik Değerlendirilmesi
Çeliker, Fatma Beyazal; Tümkaya, Levent; Mercantepe, Tolga; Beyazal, Mehmet; Turan, Arzu; Burakgazi, Gülen; Hürsoy, Nur (2023)Amaç: Gadolinyum tabanlı kontrast ajanlar (GBCA), manyetik rezonans görüntülemelerde (MRG) kontrast sağlamak amaçlı kullanılmaktadır. GBKA yapısına bağlı olarak beyin dokusu ve diğer dokularda birikim olduğu ile ... -
Melatonin ameliorates periodontitis related inflammatory stress at cardiac left ventricular tissues in rats
Köse, Oğuz; Bayraktar, Sevda Kurt; Akyıldız, Kerimali; Altın, Ahmet; Arabacı, Taner; Yemenoğlu, Hatice; Korkmaz, Mehmet Zihni; Köse, Taha Emre; Şener, Leyla Türker; Mercantepe, Tolga; Tümkaya, Levent; Yılmaz, Adnan (Wiley, 2020)BackgroundThe aim of this experimental rat study was to investigate the potential inflammatory effects of periodontitis on cardiac left ventricular tissue and the therapeutic activity of melatonin on these effects. ... -
Melatonin improves periodontitis-induced kidney damages by decreasing inflammatory stress and apoptosis in rats
Köse, Oğuz; Bayrakdar, Sevda Kurt; Ünver, Büşra; Altın, Ahmet; Akyıldız, Kerimali; Mercantepe, Tolga; Bostan, Semih Alperen; Arabacı, Taner; Türker Şener, Leyla; Köse, Taha Emre; Tümkaya, Levent; Yılmaz, Adnan; Kuluşlu, Göker (Wiley-Blackwell, 2020)Background: Two main aims of this animal study were to inspect the possible effects of periodontitis on the structure and functions of the kidneys and the therapeutic effectiveness of melatonin. Methods: Twenty-four male ... -
Mobile phone radiation during pubertal development has no effect on testicular histology in rats
Tümkaya, Levent; Kalkan, Yıldıray; Baş, Orhan; Yılmaz, Adnan (Sage Publications Inc, 2016)Mobile phones are extensively used throughout the world. There is a growing concern about the possible public health hazards posed by electromagnetic radiation emitted from mobile phones. Potential health risk applies ... -
The nephroprotective effect of amifostine in a cecal ligation-induced sepsis model in terms of oxidative stress and inflammation
Batçık, Şule; Tümkaya, Levent; Mercantepe, Tolga; Atak, Mehtap; Topçu, Atilla; Uydu, Hüseyin Avni; Mercantepe, F. (Verduci Editore, 2022)OBJECTIVE: Sepsis is responsible for more than 5 million deaths worldwide every year. The purpose of this study was to use amifostine to reduce acute kidney injury developing as a result of sepsis. MATERIALS AND METHODS: ... -
Neuroprotective effects of Vaccinium myrtillus on damage-related brain injury
Özdemir, Abdullah; Mercantepe, Tolga; Erdivanlı, Başar; Şen, Ahmet; Mercantepe, Filiz; Tümkaya, Levent; Uydu, Hüseyin Avni (2023)Traumatic brain injury may trigger the secondary brain injury, which has the potential to be reversible and thus preventable. Anthocyanins are phylotherapeutic plants, which are reported to exhibit anti-inflammatory ... -
Neurotoxicity of various root canal sealers on rat sciatic nerve: an electrophysiologic and histopathologic study
Kılkış, Buket Tuğ; Er, Kürşat; Taşdemir, Tamer; Yıldırım, Mehmet; Taşkesen, Fatih; Tümkaya, Levent; Kalkan, Yıldıray; Serper, Ahmet (Springer Heidelberg, 2015)Objectives the aim of this study was to compare the neurotoxicity of various root canal sealers on rat sciatic nerve by electrophysiologic and histopathologic analyses. Materials and methods A total of 40 male rats were ... -
A novel model approach for esophageal burns in rats: a comparison of three methods
Kalkan, Yıldıray; Tümkaya, Levent; Akdoğan, Remzi Adnan; Yücel, Ahmet Fikret; Tomak, Yakup; Şehitoğlu, İbrahim; Pergel, Ahmet; Kurt, Aysel (Sage Publications Inc, 2015)Background: Corrosive esophageal injury causes serious clinical problems. We aimed to create a new experimental esophageal burn model using a single catheter without a surgical procedure. Materials and methods: We conducted ... -
Pathological findings observed in the kidneys of postnatal male rats exposed to the 2100 MHz electromagnetic field
Bedir, Recep; Tümkaya, Levent; Mercantepe, Tolga; Yılmaz, Adnan (Elsevier Science Inc, 2018)Background. the widespread use by young people of modern communication devices such as mobile phones means that they are particularly exposed to electromagnetic fields (EMF) and other problems. However, few studies have ... -
Pelvic radiation-induced testicular damage: an experimental study at 1 gray
Rakıcı, Sema Yılmaz; Güzel, Ali İrfan; Tümkaya, Levent; Nalkıran, Hatice Sevim; Mercantepe, Tolga (Taylor & Francis Inc, 2020)Therapeutic radiation of the pelvic region has been shown to cause damage to testicular germ cells. in this study we aimed to evaluate the effects of a low therapeutic dose of 1 Gy on the induction of cellular and histological ... -
Periodontitis exacerbates the renal degenerative effects of obesity in rats
Kurt-Bayrakdar, Sevda; Köse, Oğuz; Altın, Ahmet; Akyıldız, Kerimali; Mercantepe, Tolga; Bostan, Semih Alperen; Köse, Taha Emre; Tümkaya, Levent; Yılmaz, Adnan (Wiley, 2021)Background/objectives Obesity and periodontitis are systemic subclinical inflammatory diseases with established negative renal effects. The aim of this animal study was to thoroughly investigate the possible effects of ... -
The potential antioxidant effect of N-acetylcysteine on X-ray ionizing radiation-induced pancreas islet cell toxicity
Yılmaz, Hamit; Mercantepe, Tolga; Tümkaya, Levent; Merca; Yılmaz, Adnan; Rakıcı, Sema Yılmaz (Elsevier, 2023)Purpose Previous research has highlighted the impact of X-ray irradiation-induced organ damage, on cancer patients after radiation therapy. The ionizing radiation-induced oxidative stress causes injury to the pancreatic ... -
Prenatal effects of a 1,800-MHz electromagnetic field on rat livers
Tümkaya, Levent; Yılmaz, Adnan; Akyıldız, Kerimali; Mercantepe, Tolga; Yazıcı, Zihni Acar; Yılmaz, Hamit (Karger, 2019)The use of devices, including mobile phones, generating electromagnetic fields (EMF) is widespread and is progressively increasing. It has also been shown that EMF may have detrimental effects. This is the first study to ... -
Preventive effects of melatonin on periodontal tissue destruction due to psychological stress in rats with experimentally induced periodontitis
Bostan, Semih Alperen; Yemenoğlu, Hatice; Köse, Oğuz; Akyıldız, Kerimali; Mercantepe, Tolga; Saral, Sinan; Tümkaya, Levent; Yılmaz, Adnan (Wiley, 2024)Objective and Background: Psychological stress is a potential modifiable environmental risk factor causally related to the exacerbation of periodontitis and other chronic inflammatory diseases. This animal study aimed to ... -
The protective effect of adalimumab on renal injury in a model of abdominal aorta cross-clamping
Cüre, Medine Cumhur; Cüre, Erkan; Kalkan, Yıldıray; Tümkaya, Levent; Aydın, İbrahim; Kırbaş, Aynur; Efe, Hasan; Kurt, Aysel; Yüce, Süleyman (Wroclaw Medical Univ, 2016)Background. Adalimumab (ADA) is a potent inhibitor of tumor necrosis factor (TNF-alpha). ADA treatment suppresses proinflammatory cytokines, leading to a decrease or inhibition of the inflammatory process. Objectives. the ... -
Protective effect of astaxanthin against cisplatin-induced gastrointestinal toxicity in rats
Yılmaz, Yeliz; Tümkaya, Levent; Mercantepe, Tolga; Akyıldız, Kerimali (Springer Wien, 2022)Background the aim of the present study was to demonstrate astaxanthin's attenuating effects against cisplatin (CIS)-induced gastrointestinal toxicity in a rat model. Methods Thirty-two Wistar rats (weight 200-250 g) were ...