Konu "Rat" için TF, Temel Tıp Bilimleri Bölümü Koleksiyonu listeleme
Toplam kayıt 59, listelenen: 1-20
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Agomelatine on cisplatin-induced nephrotoxicity via oxidative stress and apoptosis
(Springer, 2023)Drug-induced nephrotoxicity is the greatest deterrent to the use of cisplatin, which is a frequently used chemotherapeutic with proven efectiveness in cancer therapy. Agomelatine, which is used in the treatment of sleep ... -
Biochemical and histopathological investigation of liver tissues on high fat diet fed rats
(Galenos Yayıncılık, 2022)Objective: Hepatic steatosis is a common cause of liver disease and has become more prevalent recently. This study was conducted to investigate the biochemical and histopathological changes in the liver tissue high fat ... -
Can dexmedetomidine be effective in the protection of radiotherapy-induced brain damage in the rat?
(Springer, 2021)Approximately 7 million people are reported to be undergoing radiotherapy (RT) at any one time in the world. However, it is still not possible to prevent damage to secondary organs that are off-target. This study, therefore, ... -
Can prenatal exposure to a 900 MHz electromagnetic field affect the morphology of the spleen and thymus, and alter biomarkers of oxidative damage in 21-day-old male rats?
(Taylor & Francis Ltd, 2015)We investigated the effects of a 900 Megahertz (MHz) electromagnetic field (EMF), applied during the prenatal period, on the spleen and thymus of 21-day-old male rat pups. Pregnant Sprague-Dawley rats were divided into ... -
Chondroprotective effects of a new glucosamine combination in rats: Gene expression, biochemical and histopathological evaluation
(Pergamon-Elsevier Science Ltd, 2015)Aims: This study investigates the effect of a new combination of glucosamine hydrochloride, chondroitin sulfate, methylsulfonylmethane, Harpagophytum procumbens root extract (standardized to 3% harpagoside) and bromelain ... -
Chronic prenatal exposure to the 900 megahertz electromagnetic field induces pyramidal cell loss in the hippocampus of newborn rats
(Sage, 2009)Widespread use of mobile phones which are a major source of electromagnetic fields might affect living organisms. However, there has been no investigation concerning prenatal exposure to electromagnetic fields or their ... -
Comparative analysis of epigallocatechin-3-gallate and TNF-alpha inhibitors in mitigating cisplatin-induced pancreatic damage through oxidative stress and apoptosis pathways
(Springer, 2024)Oxidative stress and inflammation caused by cisplatin, which is frequently used in the treatment of many cancers, damage healthy tissues as well as cancer cells. In this study, we aimed to investigate the effect of ... -
A comparative investigation of the nephrotoxic effects of various antihypertensive drugs in rats: biochemical and histopathological analysis
(Carbone Editore, 2014)Aims: Hypertension is known to cause potentially fatal kidney damage. However, it is unclear whether long-term use of antihypertensive drugs establishes any toxic effect on the kidney. This study investigate whether ... -
The effect of acute organophosphate intoxication on female rat hippocampus cornu ammonis region pyramidal neuron numbers, biochemistry and morphology
(Elsevier, 2019)Background: the most commonly used insecticides and pesticides worldwide are organophosphate compounds, chemicals that irreversibly inhibit the cholinesterase enzyme. Acute intoxication with cholinesterase inhibitors is ... -
The effect of exposure of rats during prenatal period to radiation spreading from mobile phones on renal development
(Informa Healthcare, 2015)Background: the aim of this study was to investigate the effects of exposure to a 900-MHz electromagnetic field (EMF) produced by mobile phones on the renal development of prenatal rats. Histopathological changes and ... -
The effect of gadolinium-based contrast agents on rat testis
(Wiley, 2018)Previous studies have reported that repeated administrations of linear gadolinium-based contrast agents lead to their accumulation in the brain and other tissues in individuals with normal renal functions. the purpose of ... -
The effect of imatinib administered in the prenatal period on testis development in rats
(Sage Publications Ltd, 2021)Background: the purpose of this study was to examine the effects of exposure to imatinib in the prenatal period on testis development in rats. Methods: Although all the study groups received intraperitoneal imatinib on ... -
Effect of infliximab on acute hepatic ischemia/reperfusion injury in rats
(E-Century Publishing Corp, 2015)This study aimed to investigate the hepatoprotective and antioxidant effects of infliximab (IFX) against liver ischemia/reperfusion (I/R) injury in rats. A total of 30 male Wistar albino rats were divided into three groups: ... -
The effect of rocuronium, sugammadex, and their combination on cardiac muscle and diaphragmatic skeletal muscle cells
(Springer Link, 2012)Purpose: Rocuronium has been associated with muscle weakness when administered in prolonged infusions. The effect of sugammadex and rocuronium together on muscle is unknown. In this study, we examined the effects of ... -
The effect of royal jelly on CD3+, CD5+, CD45+ T-cell and CD68+ cell distribution in the colon of rats with acetic acid-induced colitis
(Elsevier, 2012)Background: Traditional medicines and health supplements have historically been used to treat many illnesses but most of them have not been evaluated objectively to prove their efficacy. We have been investigating the ... -
Effect of sugammadex on rocuronium induced changes in pancreatic mast cells
(Sage Publications Inc, 2015)Mast cells play a vital role in hypersensitivity reactions. Rocuronium is known to cause mast cell mobilization, hypersensitivity, and pancreatitis. the aim of this study was to investigate the effects of sugammadex on ... -
The effect of the calcium channel blocker nimodipine on hippocampal BDNF/Ach levels in rats with experimental cognitive impairment
(Taylor & Francis Ltd., 2023)Objective Alzheimer’s disease (AD) occurs in approximately 10% to 30% of individuals aged 65 or older worldwide. Novel therapeutic agents therefore need to be discovered in addition to traditional medications. Nimodipine ... -
Effect of the prenatal electromagnetic field exposure on cochlear nucleus neurons and oligodendrocytes in rats
(Springer Heidelberg, 2022)Electromagnetic radiation from elecromagnetic field (EMF) sources has been an important health concern for a long time. The vast majority of this exposure is due to the widespread use of mobile phones, an important source ... -
The effects of amiodarone in ovarian injury due to oxidative stress and inflammation caused by ischemia-reperfusion
(Taylor & Francis Ltd., 2022)Objective Ovarian ischemia constitutes 2-3% of all gynecological emergencies. New-generation therapeutic agents need to be discovered, in addition to invasive interventions capable of reducing the risk of potential ovarian ... -
The effects of coenzyme Q10 (CoQ10) on Ionizing radiation- induced pancreatic β-cell injury
(AVES, 2023)Objective: This study investigated the antioxidant effect of coenzyme Q10 on ionizing radiation induced oxidative damage in pancreatic & beta;-cells. Methods: Twenty-four male rats were assigned to 4 groups. Group 1 ...