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Kinetic characterization of GES-22 beta-lactamase harboring the M169L clinical mutation
(Japan Antibiotics Research Assoc, 2016)
The class A p-lactamase GES-22 has been identified in Acinetobacter baumannii isolates in Turkey, and subsequently shown to differ from GES-11 by a single substitution (M169L). Because M169 is part of the omega loop, a ...
A Novel integron gene cassette harboring VIM-38 Metallo-beta-lactamase in a clinical pseudomonas aeruginosa isolate
(Korean Soc Laboratory Medicine, 2016)
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Multidrug resistance of Pseudomonas aeruginosa has been attributed to both intrinsic and acquired antibiotic-resistance mechanisms. Multidrug-resistant (MDR) P. aeruginosa isolates have become a serious ...
Comparison of verona integron-borne metallo-beta-lactamase (VIM) variants reveals differences in stability and inhibition profiles
(Amer Soc Microbiology, 2016)
Metallo-beta-lactamases (MBLs) are of increasing clinical significance; the development of clinically useful MBL inhibitors is challenged by the rapid evolution of variant MBLs. the Verona integron-borne metallo-beta-lactamase ...
A multicenter evaluation of blood culture practices, contamination rates, and the distribution of causative bacteria
(Ahvaz Jundishapur Univ Med Sci, 2016)
Background: the prognostic value of blood culture testing in the diagnosis of bacteremia is limited by contamination. Objectives: in this multicenter study, the aim was to evaluate the contamination rates of blood cultures ...
Determination of the staphylococcal cassette chromosome in methicillin-resistant Staphylococcus aureus strains isolated from various clinical samples
(Science & Innovation, Ltd, 2016)
Aim - the present study aimed to detect mecA and staphylococcal cassette chromosome mec (SCCmec) types in methicillin-resistant Staphylococcus aureus (MRSA) isolates obtained from various clinical samples in two university ...