Yazar "Altuner, Durdu" için listeleme
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Biochemically and histopathologically comparative review of thiamine's and thiamine pyrophosphate's oxidative stress effects generated with methotrexate in rat liver
Demiryılmaz, İsmail; Şener, Ebru; Çetin, Nihal; Altuner, Durdu; Süleyman, Bahadır; Albayrak, Fatih; Akçay, Fatih (2012)Background: Oxidative liver injury occurring with methotrexate restricts its use in the desired dose. Therefore, whether or not thiamine and thiamine pyrophosphate, whose antioxidant activity is known, have protective ... -
Can thiamine pyrophosphate prevent desflurane induced hepatotoxicity in rats?
Arslan, Aynur; Kuyrukluyıldız, Ufuk; Binici, Orhan; Çetin, Nihal; Balcı, Mecdi Gürhan; Kuzucu, Mehmet; Yılmaz, Adnan; Altuner, Durdu; Çoban, Taha Abdülkadir (Acta Cirurgica Brasileira, 2016)PURPOSE: To investigate the effects of thiamine pyrophosphate (TPP) against desflurane induced hepatotoxicity. METHODS: Thirty experimental animals were divided into groups as healthy (HG), desflurane control (DCG), TPP ... -
A comparative investigation of biochemical and histopathological effects of thiamine and thiamine pyrophosphate on ischemia-reperfusion induced oxidative damage in rat ovarian tissue
Demiryılmaz, İsmail; Şener, Ebru; Çetin, Nihal; Altuner, Durdu; Akçay, Fatih; Süleyman, Halis (Pharmaceutical Soc Korea, 2013)In this study, the biochemical and histopathological effects of thiamine and thiamine pyrophosphate on ischemia-reperfusion induced oxidative damage in rat ovarian tissue were investigated. Animals were divided into four ... -
A comparative investigation of the analgesic effects of metamizole and paracetamol in rats
İnce, İlker; Aksoy, Mehmet; Ahıskalıoğlu, Ali; Çömez, Mehmet; Dostbil, Ayşenur; Çelik, Mine; Yılmaz, İsmail; Mammadov, Renad; Doğan, Hasan; Özgermen, Boztok; Altuner, Durdu (Informa Healthcare, 2015)Background: This study investigated the effects of metamizole and paracetamol on pain and oxidative stress induced by scalpel incision and carrageenan in rats. Materials and methods: Total of 144 rats were divided into ... -
Comparative review of biochemistry and cell anatomy of the hepatic tissue in rats administered some anti hypertensive drug for a long time
Malkoç, İsmail; Çetin, Nihal; Altuner, Durdu; Hacımüftüoğlu, Ahmet; Gürsan, Nesrin; Bakan, Ebubekir; Akçay, Fatih; Süleyman, Halis (2012)The adverse biochemical and structural effects of antihypertensive drugs over a long period (clonidine, methyldopa, rilmenidine, amlodipine, ramipril) on hepatic tissue has been examined in this study. The results are ... -
Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats
Mammadov, Renad; Süleyman, Bahadır; Altuner, Durdu; Demirci, Elif; Çetin, Nihal; Yılmaz, Adnan; Baykal, Hüseyin; Alpcan, Hilal; Turumtay, Emine Akyüz; Süleyman, Halis (Acta Cirurgica Brasileira, 2019)Purpose: To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG). Methods: the anticancer ... -
The effect of hippophae rhamnoides extract on oxidative damage on rat's gastric tissue depending on Co-implementation of methotrexate and indomethacin
Yılmaz, İsmayıl; Demiryılmaz, İsmail; Şener, Ebru; Çetin, Nihal; Üçüncü, Yılmaz; Altuner, Durdu; Kurt, Nezahat; Kunak, Semih C.; Kısaoğlu, Abdullah; Özoğul, Bünyamin; Süleyman, Halis (Colegio Farmaceuticos Provincia de Buenos Aires, 2014)The effect of Hippophae rhamnoides (HR) extract on oxidative damage on rat's gastric tissue depending on co-implementation of methotrexate (MTX) and indomethacin (IND) was investigated biochemically and histopathologically. ... -
Effect of infliximab against cisplatin-induced nephrotoxicity
Cüre, Erkan; Kırbaş, Aynur; Tümkaya, Levent; Cüre, Medine Cumhur; Şahin, Osman Zikrullah; Kalkan, Yıldıray; Yüce, Süleyman; Altuner, Durdu (Saudi Med J, 2014)Objectives: To investigate whether infliximab (Ib), an inhibitor of tumor necrosis factor alpha (TNF-alpha), prevents cisplatin (Cis)-induced nephrotoxicity. Methods: the study was performed in the Department of Internal ... -
The effect of mirtazapine on cisplatin-induced oxidative damage and infertility in rat ovaries
Altuner, Durdu; Gülaboğlu, Mine; Yapca, Ömer Erkan; Çetin, Nihal (Hindawi Ltd, 2013)Cisplatin causes infertility due to ovarian toxicity. the toxicity mechanism is unknown, but evidence suggests oxidative stress. in this study, the effect of mirtazapine on cisplatin-induced infertility and oxidative stress ... -
Effect of mirtazapine on gastric oxidative stress and DNA injury created with methotrexate in rats
Demiryılmaz, İsmail; Uzkeser, Hülya; Çetin, Nihal; Hacımüftüoğlu, Ahmet; Bakan, Ebubekir; Altuner, Durdu (Chemical Publishing Co., 2013)In this study, effect of mirtazapine on gastric oxidative stress and DNA injury created with methotrexate was investigated. Experimental results showed that GSH (nmol/g protein), MDA (?mol/g protein) and MPO (?/g protein) ... -
The effect of mirtazapine on methotrexate-induced toxicity in rat liver
Özoğul, Bünyamin; Kısaoğlu, Abdullah; Turan, Mehmet Ibrahim; Altuner, Durdu; Sener, Ebru; Çetin, Nihal; Öztürk, Cengiz (Science Society Thailand, 2013)Methotrexate is used as a chemotherapeutic agent and its anti-oxidant activity is used to treat many cancer types. This study conducts a biochemical and histopathological investigation into whether mirtazapine has a ... -
Effect of sugammadex on rocuronium induced changes in pancreatic mast cells
Kalkan, Yıldıray; Tümkaya, Levent; Bostan, Habib; Tomak, Yakup; Altuner, Durdu; Yılmaz, Adnan; Erdivanlı, Başar; Bedir, Recep; Yalçın, Alper; Turan, Alparslan (Sage Publications Inc, 2015)Mast cells play a vital role in hypersensitivity reactions. Rocuronium is known to cause mast cell mobilization, hypersensitivity, and pancreatitis. the aim of this study was to investigate the effects of sugammadex on ... -
Effect of thiamine pyrophosphate on ischemia-reperfusion induced oxidative damage in rat kidney
Altuner, Durdu; Çetin, Nihal; Süleyman, Bahadır; Aslan, Zeynep; Hacımuftuoğlu, Ahmet; Gülaboğlu, Mine; İsaoğlu, Neslihan; Demiryılmaz, İsmail; Suleyman, Halis (Wolters Kluwer Medknow Publications, 2013)Objectives: the biochemical effects of thiamine pyrophosphate on ischemia-reperfusion (IR) induced oxidative damage and DNA mutation in rat kidney tissue were investigated, and compared to thiamine. Materials and Methods: ... -
Effect of Usnea longissima ethyl acetate extract on acute oxidative and inflammatory lung damage from Staphylococcus aureus infection in rats
Dabanlıoğlu, Bülent; Süleyman, Bahadır; Mammadov, Renad; Yavuzer, Bülent; Akyüz, Sümeyey; Akkaş, Önder; Mokhtare, Behzad; Turumtay, Emine Akyüz; Altuner, Durdu; Çoban, Taha Abdulkadir; Süleyman, Halis (University of South Bohemia in Ceske Budejovice Faculty of Health and Social Sciences, 2023)The role of oxidants and proinflammatory cytokines in the pathogenesis of pneumonia caused by Staphylococcus aureus (S. aureus) has been demonstrated. The present study aims to investigate the protective effect of ethyl ... -
The effect of usnea longissima extract on lung cancer cell line (A549)
Objective: Some lichens are known to demonstrate anticancer activity. However, to the best of our knowledge, no information is available about the activity of Usnea longissima against human lung cancer A549 cells. This ... -
Effects of nimesulide on oxidative mucosal injury induced by cisplatin in rat duodenum and jejunum
Özçiçek, Fatih; Çankaya, Murat; Çimen, Ferda K.; Kafa, Ayşe H. T.; Nalkıran, Hatice Sevim; Süleyman, Bahadır; Altuner, Durdu; Çetin, Nihal (Colegio Farmaceuticos Provincia de Buenos Aires, 2016)In this study, the impact of nimesulide on oxidative stress induced by cisplatin in rat duodenum and jejunum tissue was assessed by evaluating the biochemical and histopathological changes. the rats in the study were ... -
Effects of nimesulide on the small intestine mucositis induced by methotrexate in rats
Arslan, Aynur; Özçiçek, Adalet; Süleyman, Bahadır; Çoban, Taha Abdulkadir; Çimen, Ferda Keskin; Nalkıran, Hatice Sevim; Kuzucu, Mehmet; Altuner, Durdu; Çetin, Nihal; Süleyman, Halis (Int Press Editing Centre Inc, 2016)Intestinal mucositis is one of the major problems in the patients receiving cancer treatment. Nimesulide is a drug with antioxidant, antiinflammatory and antiulcer features. We aimed to investigate the effect of nimesulide ... -
Effects of sugammadex and rocuronium mast cell number and degranulation in rat liver
Tomak, Yakup; Yılmaz, Adnan; Bostan, Habib; Tümkaya, Levent; Altuner, Durdu; Kalkan, Yıldıray; Erdivablı, Başar (Wiley, 2012)We investigated the effect of rocuronium- and sugammadex-induced mast cell increase and degranulation in rat portal triads. Forty-two rats, in six groups, received either rocuronium 1 mg.kg -1; sugammadex 15 mg.kg -1; ... -
Gene expression and histopathological evaluation of thiamine pyrophosphate on optic neuropathy induced with ethambutol in rats
Çinici, Emile; Çetin, Nihal; Süleyman, Bahadır; Altuner, Durdu; Yaralı, Oğuzhan; Balta, Hilal; Çalık, İlknur; Tümkaya, Levent; Süleyman, Halis (Ijo Press, 2016)AIM: To compare the effects of thiamine pyrophosphate (TPP) and thiamine (TM) in oxidative optic neuropathy in rats induced by ethambutol. METHODS: the animals were divided into four groups: a control group (CG), an ... -
Hepatic effects of ketamine administration for 2 weeks in rats
Kalkan, Yıldıray; Tomak, Yakup; Altuner, Durdu; Tümkaya, Levent; Bostan, Habib; Yılmaz, Adnan; Ünal, D.; Kara, A.; Turan, A. (Sage Publishing, 2014)The aim of the present study was to investigate the long-term and high-dose application of ketamine on the liver by employing histologic and biochemical methods. A total of 30 male rats were randomly assigned to control ...
