Yazar "Tümkaya, Levent" için TF, Temel Tıp Bilimleri Bölümü Koleksiyonu listeleme
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The protective effect of astaxanthin against cisplatin-induced nephrotoxicity in rats
Akça, Görkem; Eren, Hüseyin; Tümkaya, Levent; Mercantepe, Tolga; Horsanali, Mustafa Ozan; Deveci, Ezgi; Yılmaz, Adnan (Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)Purpose: the aim of this experimental study was to investigate the antioxidant effects of astaxanthin against cisplatin-induced nephrotoxicity in rats. Methods: Forty-eight male Sprague-Dawley rats weighing 264.83 +/- 7.39 ... -
The protective effect of astaxanthin on cisplatin-induced ototoxicity
Terzi, Suat; Özgür, Abdulkadir; Çeliker, Metin; Mercantepe, Tolga; Yılmaz, Adnan; Tümkaya, Levent; Kaya, Şeyma; Demir, Emine; Dursun, Engin (Wroclaw Medical Univercity, 2021)Background. Promising studies have been conducted with many substances to reduce the ototoxic effects of cisplatin, but there is no treatment that completely eliminates the ototoxic effect. Objectives. To determine the ... -
The protective effect of infliximab against carbon tetrachloride-induced acute lung injury
Kurt, Aysel; Tümkaya, Levent; Yüce, Süleyman; Türüt, Hasan; Cüre, Medine Cumhur; Şehitoğlu, İbrahim; Kalkan, Yıldıray; Pusuroğlu, Gökhan; Cüre, Erkan (Mashhad Univ Med Sciences, 2016)Objective(s): Carbon tetrachloride (CCl4) causes pulmonary toxicity. Infliximab (Ib) is a potent inhibitor of tumor necrosis factor-alpha (TNF-alpha). We aimed to investigate whether Ib has a protective effect on CCl4 ... -
Protective effect of infliximab against carbon tetrachloride-induced hepatotoxicity
Şehitoğlu, İbrahim; Tümkaya, Levent; Bedir, Recep; Özer, Ender; Cüre, Medine Cumhur; Yüce, Süleyman; Kalkan, Yıldıray; Cüre, Erkan (Begell House Inc, 2015)Carbon tetrachloride (CCl4), a solvent frequently used in industry, can cause acute liver failure and liver fibrosis. Infliximab (Ib), a potent tumor necrosis factor alpha blocker, has a protective effect on the liver. ... -
Protective effect of infliximab on methotrexate-induced liver injury in rats: Unexpected drug interaction
Cüre, Erkan; Kırbaş, Aynur; Tümkaya, Levent; Cüre, Medine Cumhur; Kalkan, Yıldıray; Yılmaz, Arif; Yüce, Süleyman (Wolters Kluwer Medknow Publications, 2015)Aims: Although methotrexate (mtx) is a widely used agent to treat cancer and inflammatory diseases, its hepatotoxic effect limits for clinical utility. We aimed to investigate whether infliximab (inf), an inhibitor of tumor ... -
Protective effect of resveratrol against methotrexate-induced oxidative stress in the small intestinal tissues of rats
Arslan, Aynur; Özçiçek, Fatih; Çimen, Ferda Keskin; Altuner, Durdu; Yaralı, Oğuzhan; Kurt, Nezahat; Tümkaya, Levent; Öztürk, Cengiz; Süleyman, Halis (E-Century Publishing Corp, 2015)The effect of resveratrol on the damage induced by methotrexate (MTX) in rat duodenum and jejunum tissue was investigated and evaluated in comparison with famotidine. the rats were divided into four groups as healthy group ... -
Protective effect of tea grape extract on cisplatin-induced muscle atrophy: A morphological study
Balık, Mehmet Sabri; Tümkaya, Levent; Mercantepe, Tolga; Yılmaz, Adnan; Balık, Gülşah; Topçu, Atilla; Yazıcı, Zihni Açar (Kowsar Publ, 2018)Background: Even though Cisplatin (Cis) is known to be organotoxic, it is used in neoplastic chemotherapy. in skeletal muscles, the toxic effect manifests as atrophy. Objectives: the tea grape extract (TGE) is a sort of ... -
Protective effect of thymoquinone in preventing trauma-related damage: an experimental study
Erdivanlı, Başar; Özdemir, Abdullah; Şen, Ahmet; Mercantepe, Tolga; Kazdal, Hızır; Uydu, Hüseyin Avni; Tümkaya, Levent (Taylo & Francis Ltd., 2021)Background Secondary injury is a potentially modifiable factor of outcome in traumatic brain injury. This study aimed to investigate thymoquinone's effects on trauma-induced neuronal damage. Methods Eighteen adult female ... -
Protective effect of vaccinium myrtillus extract on x-ray irradiation-induced retinal toxicity via enos and 8-ohdgexpression
Fındık, Hüseyin; Aslan, Mehmet Gökhan; Okutucu, Murat; Yılmaz, Adnan; Tümkaya, Levent; Mercantepe, Tolga; Akyıldız, Kerimali; Uzun, Fatma (Karger, 2023)Every year, hundreds of thousands of cancer patients receive radiotherapy treatment. Oxidative stress is observed in healthy tissues due to irradiation exposure. The present study is the first to address the effects of ... -
Protective effect of whortleberry extract on salivary gland damage induced by neck irradiation in rats
Özgür, Abdulkadir; Terzi, Suat; Özdemir, Doğukan; Tümkaya, Levent; Rakıcı, Sema; Mercantepe, Tolga; Yılmaz, Adnan; Çeliker, Metin; Dursun, Engin (Sage Publications Inc, 2019)Radiotherapy is a method of treatment used on malignant head and neck tumors; however, it may lead to adverse effects by influencing other tissues because its effects are not specific to tumor tissues. These adverse effects ... -
The protective effects of adalimumab on intestinal injury induced with infrarenal aortic occlusion
Pergel, Ahmet; Tümkaya, Levent; Demiral, Gökhan; Çolakoğlu, Muhammet Kadri; Kalcan, Süleyman; Özdemir, Ali; Mercantepe, Tolga; Erdivanlı, Başar; Yılmaz, Adnan (Turkish Assoc Trauma Emergency Surgery, 2020)BACKGROUND: the present study aims to observe the effects of ischemia-reperfusion (IR) on small intestines at a molecular level and to prospectively assess the potential preventive role of adalimumab (ADA) and antioxidants. ... -
Protective effects of amifostine, curcumin and caffeic acid phenethyl ester against cisplatin-induced testis tissue damage in rats
Mercantepe, Tolga; Ünal, Deniz; Tümkaya, Levent; Yazıcı, Zihni Açar (Spandidos Publ Ltd, 2018)Cisplatin is an effective antineoplastic drug that is usually used to treat a number of different types of cancer in the clinic. One of the most notable side effects of cisplatin use is infertility. the present study was ... -
Protective effects of amifostine, curcumin, and melatonin against cisplatin-induced acute kidney injury
Mercantepe, Filiz; Mercantepe, Tolga; Topçu, Atilla; Yılmaz, Adnan; Tümkaya, Levent (Springer, 2018)Despite the enormous advances made in the field of oncology, no solution to the side effect of nephrotoxicity caused by cisplatin used as an antineoplastic agent for approximately 40 years has yet been discovered. This ... -
The protective effects of angiotensin-converting enzyme inhibitor against cecal ligation and puncture-induced sepsis via oxidative stress and inflammation
Kostakoğlu, Uğur; Topçu, Atilla; Atak, Mehtap; Tümkaya, Levent; Mercantepe, Tolga; Uydu, Hüseyin Avni (Pergamon-Elsevier Science Ltd, 2020)Aims: Sepsis is a severe public health problem affecting millions of individuals, with global mortality rates caused by lower respiratory tract infections are approximately 2.38 million people a year die from respiratory ... -
The protective effects of astaxanthin against cisplatin-induced retinal toxicity
Fındık, Hüseyin; Tümkaya, Levent; Yılmaz, Adnan; Aslan, Mehmet Gökhan; Okutucu, Murat; Akyıldız, Kerimali; Mercantepe, Tolga (Taylor & Francis Ltd, 2019)Purpose: This study investigated the toxic effects of an antineoplastic agent, cisplatin (CIS), on retinal cells and the potential capacity of astaxanthin (ASTA) to elicit a future therapeutic protocol in CIS-induced retinal ... -
The protective effects of ginseng on x-irradiation-induced intestinal damage in rats
Özdemir, Ali; Tümkaya, Levent; Mercantepe, Tolga; Samancı, Tuğba Çelik; Uyan, Mikail; Kalcan, Süleyman; Demiral, Gökhan; Pergel, Ahmet; Kutlu, Eda Yılmaz; Yılmaz, Hülya Kılıç (Springer, 2023)Although radiotherapy is widely employed in the treatment of various malignancies in oncology patients, its use is limited by the toxic effects it causes in surrounding tissues, including the gastrointestinal system. Korean ... -
Protective effects of hyperbaric oxygen and iloprost on ischemia/reperfusion-induced lung injury in a rabbit model
Bozok, Şahin; İlhan, Gökhan; Bozok, Yeliz Yılmaz; Dökümcü, Zafer; Tümkaya, Levent; Karamustafa, Hakan; Karakaşı, Sedat Ozan; Ergene, Şaban; Şener, Erol (Biomed Central Ltd, 2012)Background: the role of multiorgan damage in the mortality caused by ischemic limb injury is still not clarified. the objective of this study was to examine the potential protective effects of hyperbaric oxygen (HBO) and ... -
Protective effects of infliximab on lung injury induced by methotrexate
Kurt, Aysel; Tümkaya, Levent; Türüt, Hasan; Cüre, Medine Cumhur; Cüre, Erkan; Kalkan, Yıldıray; Şehitoğlu, İbrahim; Acıpayam, Ahmet (Elsevier Espana Slu, 2015)Introduction: Methotrexate (MTX) is used to treat cancers, several forms of arthritis and other rheumatic conditions, although MIX may cause pulmonary toxicity related to the production of free oxygen radicals, various ... -
Protective effects of nebivolol on ovarian ischemia-reperfusion injury in rat
Çolak, Sabri; Gürlek, Beril; Topçu, Atilla; Tümkaya, Levent; Mercantepe, Tolga; Yılmaz, Adnan (Wiley, 2020)Aim Ovarian torsion is a common gynecological emergency of reproductive ages, occurring at rates of 2.7-7.4%. This study aimed to evaluate the antioxidant effects of Nebivolol (NEB) and histopathological changes in ...