Konu "Cisplatin" için TF, Temel Tıp Bilimleri Bölümü Koleksiyonu listeleme
Toplam kayıt 17, listelenen: 1-17
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Agomelatine attenuates cisplatin-induced cognitive impairment via modulation of BDNF/TrkB signaling in rat hippocampus
(Elsevier, 2023)Cisplatin is a drug used effectively in the treatment of malignant tumors. However, cisplatin has many side ef-fects, including cognitive impairment. Agomelatine, a synthetic melatonin analogue, is an important antide-pressant. ... -
Agomelatine on cisplatin-induced nephrotoxicity via oxidative stress and apoptosis
(Springer, 2023)Drug-induced nephrotoxicity is the greatest deterrent to the use of cisplatin, which is a frequently used chemotherapeutic with proven efectiveness in cancer therapy. Agomelatine, which is used in the treatment of sleep ... -
Anticancer effects of a novel herbal combination as a potential therapeutic candidate against lung cancer
(Elsevier Science, 2021)Introduction: Cancer continues to be a prevalent health problem with increasing mortality rates. The interest in complementary medicine for cancer treatment has increased in recent years. In this study, we aimed to investigate ... -
Apelin-13 activates the hippocampal BDNF/TrkB signaling pathway and suppresses neuroinflammation in male rats with cisplatin-induced cognitive dysfunction
(Elsevier, 2021)It has been established that cisplatin causes neuronal damage and cognitive impairment. However, the mechanism is not sufficiently clear. Apelin-13 is an endogenous peptide with strong neuroprotective effects through the ... -
Comparative analysis of epigallocatechin-3-gallate and TNF-alpha inhibitors in mitigating cisplatin-induced pancreatic damage through oxidative stress and apoptosis pathways
(Springer, 2024)Oxidative stress and inflammation caused by cisplatin, which is frequently used in the treatment of many cancers, damage healthy tissues as well as cancer cells. In this study, we aimed to investigate the effect of ... -
The effect of white tea on serum TNF-alpha/NF-kappa B and immunohistochemical parameters in cisplatin-related renal dysfunction in female rats
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2019)Objective: Nephrotoxicity is the most important side effect of the antineoplastic drug cisplatin, thereby restricting its use. the aim of this study was to investigate the protective effects of white tea infusions(WT) ... -
The effects of apelin-13 against cisplatin-induced nephrotoxicity in rats
(Taylo & Francis Ltd., 2021)Acute kidney injury (AKI) is observed in nearly 60% of patients undergoing cisplatin (CP) therapy. The aim of this study was to reveal the potential effects of apelin-13 (AP-13) in the prevention of CP-induced renal toxicity, ... -
Effects of hippophae rhamnoides extract on oxidative mucosal injury induced by cisplatin in rat jejunum
(Scientific Publishers of India, 2018)Objectives: We aimed to assess the effect of Hippophae rhamnoides extract (HR) on oxidative stress induced by cisplatin (Cis) in rat small intestine tissue by evaluating the biochemical and gene expression levels and ... -
The effects of white tea (Camellia Sinensis) and infliximab against cisplatin-induced testicular damage via oxidative stress and apoptosis
(2023)Cisplatin (Cis) is an important chemotherapeutic agent used in cancer treatment. Males exposed to Cis were reported to exhibit testicular toxicity. Cis-induced testicular toxicity is mediated by oxidative stress, inflammation, ... -
Infliximab modulates cisplatin-induced hepatotoxicity in rats
(Galenos Publ, 2016)Background: Cisplatin (Cis) is one of the most com-monly used antineoplastic drugs. It is used as chemo-therapy for many solid organ malignancies such as brain, neck, male and female urogenital, vesical and pulmonary ... -
The protective effect of astaxanthin against cisplatin-induced nephrotoxicity in rats
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)Purpose: the aim of this experimental study was to investigate the antioxidant effects of astaxanthin against cisplatin-induced nephrotoxicity in rats. Methods: Forty-eight male Sprague-Dawley rats weighing 264.83 +/- 7.39 ... -
The protective effect of astaxanthin on cisplatin-induced ototoxicity
(Wroclaw Medical Univercity, 2021)Background. Promising studies have been conducted with many substances to reduce the ototoxic effects of cisplatin, but there is no treatment that completely eliminates the ototoxic effect. Objectives. To determine the ... -
The protective effect of infliximab on cisplatin-induced intestinal tissue toxicity
(Verduci Publisher, 2014)OBJECTIVE: Cisplatin (CP) is a popular chemotherapeutic agent. However, high doses of CP may lead to severe side effects to the gastrointestinal system. the aim of this study was to investigate the protective effects of ... -
Protective effect of tea grape extract on cisplatin-induced muscle atrophy: A morphological study
(Kowsar Publ, 2018)Background: Even though Cisplatin (Cis) is known to be organotoxic, it is used in neoplastic chemotherapy. in skeletal muscles, the toxic effect manifests as atrophy. Objectives: the tea grape extract (TGE) is a sort of ... -
Protective effects of amifostine, curcumin and caffeic acid phenethyl ester against cisplatin-induced testis tissue damage in rats
(Spandidos Publ Ltd, 2018)Cisplatin is an effective antineoplastic drug that is usually used to treat a number of different types of cancer in the clinic. One of the most notable side effects of cisplatin use is infertility. the present study was ... -
Protective effects of amifostine, curcumin, and melatonin against cisplatin-induced acute kidney injury
(Springer, 2018)Despite the enormous advances made in the field of oncology, no solution to the side effect of nephrotoxicity caused by cisplatin used as an antineoplastic agent for approximately 40 years has yet been discovered. This ... -
The protective effects of whortleberry extract against cisplatin-induced ototoxicity in rats
(Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, 2019)Introduction: Cisplatin is one of the main chemotherapeutic agents used for the treatment of many types of cancer. However, ototoxicity, one of the most serious side effects of cisplatin, extract restricts its usage. ...